Abnormal Functional Connectivity Within Default Mode Network and Salience Network Related to Tinnitus Severity

Xiong, Binbin; Liu, Zhao; Li, Jiahong; Huang, Xiayin; Yang, Jing; Wang, Xu; Chen, Yu‐Chen; Cai, Yixi; Zheng, Yiqing

doi:10.1007/s10162-023-00905-2

Cited by 5 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The THI provides additional data to the traditional psychoacoustic assessment (e.g., pitch and loudness matching, minimum masking levels, residual inhibition). Tinnitus severity is categorized as follows: no handicap (0-16 points), 'mild' (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36), 'moderate' (38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56), 'severe' (58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)…”

Section: Audiological Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Bridging the Gap between Psychophysiological and Audiological Factors in the Assessment of Tinnitus: An EEG Investigation in the Beta Band

Inguscio,

Rossi,

Giliberto

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

Background: Despite substantial progress in investigating its psychophysical complexity, tinnitus remains a scientific and clinical enigma. The present study, through an ecological and multidisciplinary approach, aims to identify associations between electroencephalographic (EEG) and psycho-audiological variables. Methods: EEG beta activity, often related to stress and anxiety, was acquired from 12 tinnitus patients (TIN group) and 7 controls (CONT group) during an audio cognitive task and at rest. We also investigated psychological (SCL-90-R; STAI-Y; BFI-10) and audiological (THI; TQ12-I; Hyperacusis) variables using non-parametric statistics to assess differences and relationships between and within groups. Results: In the TIN group, frontal beta activity positively correlated with hyperacusis, parietal activity, and trait anxiety; the latter is also associated with depression in CONT. Significant differences in paranoid ideation and openness were found between groups. Conclusions: The connection between anxiety trait, beta activity in the fronto-parietal cortices and hyperacusis provides insights into brain functioning in tinnitus patients, offering quantitative descriptions for clinicians and new multidisciplinary treatment hypotheses.

show abstract

Section: Audiological Assessmentmentioning

confidence: 99%

“…Its activation is relatively strongest during cognitive effort and negatively correlated with the DMN [ 40 ]. Finally, the auditory network (AN) is responsible for recognizing noise and speech [ 43 ]. Interestingly, changes in the AN, SN, DMN, and FPN have been shown in patients with tinnitus [ 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Bridging the Gap between Psychophysiological and Audiological Factors in the Assessment of Tinnitus: An EEG Investigation in the Beta Band

Inguscio,

Rossi,

Giliberto

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

show abstract

“…Electroacupuncture treatment could reduce FC values of the amygdala, cingulate gyrus and related brain areas, promote functional recombination of auditory and emotional-related brain areas, and effectively improve clinical symptoms of ST patients. Recent studies suggested that insula (INS) was the core region of the neural pathway composed of the auditory cortex, the insula and the parahippocampus/posterior cingulate gyrus, and abnormal FC between INS and the auditory cortex, the posterior cingulate gyrus and the parahippocampus existed in ST patients (14). And whether the central action mechanism of acupuncture treatment of ST is related to the regulation of functional connections between INS and related brain regions.…”

Section: Introductionmentioning

confidence: 99%

Modulations of resting-static functional connectivity on insular by electroacupuncture in subjective tinnitus

Zha,

Zhang,

Shi

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

ObjectiveTo explore the modulations of electroacupuncture in subjective tinnitus (ST) by comparing the difference of functional connectivity (FC) in ST patients and healthy volunteers between the insular (INS) and the whole brain region.MethodsA total of 34 ST patients were selected into electroacupuncture group (EG) and 34 age- and sex-matched normal subjects were recruited into control group (CG). The EG received acupuncture at SI19 (Tinggong), GB11 (Touqiaoyin), TE17 (Yifeng), GV20 (Baihui), GV15 (Yamen), GV14 (Dazhui), SJ13 (Zhongzhu), among which the points of SI19 and GB11 were connected to the electroacupuncture instrument with the density wave of 2/50 Hz, and 3 treatments per week for 10 sessions in total. The severity of tinnitus was evaluated by Tinnitus Handicap Inventory (THI), the hearing status was recorded using pure tone audiometry, and resting-state functional magnetic resonance imaging (rs-fMRI) was performed on the brain before and after treatment, the CG received no intervention yet only rs-fMRI data were collected.ResultsWith the electroacupuncture treatment, the total THI score, average air conduction threshold of patients of EG were significantly lower than before (p < 0.01), and the total effective rate was 88.24%. Compared with CG, FC of ST patients between INS and left superior temporal gyrus and right hippocampal significantly decreased before treatment, while FC of ST patients between INS and right superior frontal gyrus, left middle frontal gyrus and right anterior cuneus significantly decreased after treatment (voxel p < 0.001, cluster p < 0.05, corrected with GRF). FC of ST patients between the INS and right middle frontal gyrus, left superior frontal gyrus and right paracentral lobule showed a significant decrease after treatment (voxel p < 0.001, cluster p < 0.05, corrected with GRF). In addition, THI score in EG was negatively correlated with the reduction of FC value in INS-left superior frontal gyrus before treatment (r = −0.41, p = 0.017). Therefore, this study suggests that abnormal FC of INS may be one of the significant central mechanisms of ST patients and can be modulated by electroacupuncture.DiscussionElectroacupuncture treatment can effectively reduce or eliminate tinnitus symptoms in ST patients and improve the hearing by decreasing FC between the INS and the frontal and temporal brain regions.

show abstract

Exploring functional connectivity alterations in sudden sensorineural hearing loss: A multilevel analysis

Li,

Zou,

Kong

et al. 2024

Brain Research

View full text Add to dashboard Cite

Abnormal Functional Connectivity Within Default Mode Network and Salience Network Related to Tinnitus Severity

Cited by 5 publications

References 37 publications

Bridging the Gap between Psychophysiological and Audiological Factors in the Assessment of Tinnitus: An EEG Investigation in the Beta Band

Bridging the Gap between Psychophysiological and Audiological Factors in the Assessment of Tinnitus: An EEG Investigation in the Beta Band

Modulations of resting-static functional connectivity on insular by electroacupuncture in subjective tinnitus

Exploring functional connectivity alterations in sudden sensorineural hearing loss: A multilevel analysis

Contact Info

Product

Resources

About