Salidroside attenuates interleukin‐1β‐induced inflammation in human osteoarthritis chondrocytes

Zhang, Yuan; Zhao, Qing

doi:10.1002/jcb.27076

Cited by 19 publications

(22 citation statements)

References 35 publications

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“…Our results were consistent with previous research in vitro. 20,21 Salidroside is the bioactive component of Rhodiola rosea, which has various beneficial effects on human health. Numerous studies have mentioned that Sal was involved in the treatment of many diseases, such as non-alcoholic steatohepatitis 38 and Alzheimer's disease.…”

Section: Discussionmentioning

confidence: 99%

“…It is worth noting that Sal inhibited the production of matrix metalloproteinases induced by IL-1β in human OA chondrocytes, and had a protective effect on LPS-induced ATDC5 cell damage. 20,21 According to reports, Sal had an inhibitory effect on IL-1β-induced OA inflammation by inhibiting the activation of the NF-κB pathway in vitro. 21 Similarly, this study found that Sal reduced the number of CD4 + IL-10 + cells in OA rats and increased the number of CD4 + IL-10 + cells, thereby regulating the inflammation and immune response in OA rats.…”

Section: Discussionmentioning

confidence: 99%

“…20,21 According to reports, Sal had an inhibitory effect on IL-1β-induced OA inflammation by inhibiting the activation of the NF-κB pathway in vitro. 21 Similarly, this study found that Sal reduced the number of CD4 + IL-10 + cells in OA rats and increased the number of CD4 + IL-10 + cells, thereby regulating the inflammation and immune response in OA rats. The fibrosis of articular cartilage, which is dominated by type Ⅲ collagen deposition, can affect the local cellular metabolism and biomechanical characteristics of joints during OA.…”

Section: Discussionmentioning

confidence: 99%

“…20 Similarly, Zhang and Zhao et al reported that Sal inhibited OA inflammation induced by IL-1β through inhibiting the activation of NF-κB pathway in vitro. 21 However, the role and possible molecular mechanism of Sal in OA have not been reported in animal models.…”

Section: Introductionmentioning

confidence: 99%

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<p>Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats</p>

Gao¹,

Lü

Li³

et al. 2020

DDDT

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Introduction: Osteoarthritis (OA) is the most common disease, which seriously affects the daily life of the elderly. Currently, no traditional or drug therapy has been shown to explicitly block the progression of OA. Salidroside (Sal) is a bioactive component of Rhodiola rosea, which has many beneficial effects on human health. However, the role and mechanism of Sal in OA have not been reported. Methods: We established an anterior cruciate ligament transection (ACLT)-induced OA Rat model. The rats were divided into five groups (n = 10): Control group; ACLT group; ACLT + Sal (12.5 mg/kg) group; ACLT + Sal (25 mg/kg) group; ACLT + Sal (50 mg/kg) group. Results: The study showed that Sal could significantly promote the proliferation of chondrocytes in OA rats induced by ACLT and restore the histological alteration of cartilage. Besides, Sal upregulated the levels of Collagen II and Aggrecan, and downregulated the level of MMP-13. Furthermore, Sal could reduce the number of CD4+IL-17 + cells and decrease the levels of IL-17, IKBα and p65, while elevating the number of CD4+IL-10 + cells and the level of IL-10. The decrease of IL-17 further inhibited the dissociation of IKBα to p65, thus reducing the release of TNF-α and VCAM-1. Taken together, Sal alleviates cartilage degeneration through promoting chondrocytes proliferation, inhibiting collagen fibrosis, and regulating inflammation and immune responses via NF-κB pathway in ACLT-induced OA Rats. Discussion: Collectively, our study investigates the role and mechanism of Sal in OA, which lays a foundation for the application of Sal in OA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats</p>

Gao¹,

Lü

Li³

et al. 2020

DDDT

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“…Besides this, NO has been demonstrated to modulate COX-2 expression and prostaglandin production [ 11 ] as well as the activation of MMPs in the cartilage [ 12 ]. MMPs are well characterized enzymes involved in the degradation of the extracellular matrix (ECM) of the cartilage [ 13 , 14 ]. Among them, MMP-13 (collagenase 3) is an enzyme constitutively expressed in the chondrocyte that degrades collagenous ECM [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis

Vaamonde‐García

Burguera

Vela-Anero

et al. 2020

IJMS

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Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological activities. The purpose here was to evaluate the effects of the intraarticular administration of a slow-releasing H2S compound (GYY-4137) on an OA experimental model. OA was induced in Wistar rats by the transection of medial collateral ligament and the removal of the medial meniscus of the left joint. The animals were randomized into three groups: non-treated and intraarticularly injected with saline or GYY-4137. Joint destabilization induced articular thickening (≈5% increment), the loss of joint mobility and flexion (≈12-degree angle), and increased levels of pain (≈1.5 points on a scale of 0 to 3). Animals treated with GYY-4137 presented improved motor function of the joint, as well as lower pain levels (≈75% recovery). We also observed that cartilage deterioration was attenuated in the GYY-4137 group (≈30% compared with the saline group). Likewise, these animals showed a reduced presence of pro-inflammatory mediators (cyclooxygenase-2, inducible nitric oxide synthase, and metalloproteinase-13) and lower oxidative damage in the cartilage. The increment of the nuclear factor-erythroid 2-related factor 2 (Nrf-2) levels and Nrf-2-regulated gene expression (≈30%) in the GYY-4137 group seem to be underlying its chondroprotective effects. Our results suggest the beneficial impact of the intraarticular administration of H2S on experimental OA, showing a reduced cartilage destruction and oxidative damage, and supporting the use of slow H2S-producing molecules as a complementary treatment in OA.

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Salidroside Activates the AMP‐Activated Protein Kinase Pathway to Suppress Nonalcoholic Steatohepatitis in Mice

Zhang

et al. 2021

Hepatology

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BaCKgRoUND aND aIMS: NASH is becoming a leading cause of liver cirrhosis and HCC. Salidroside (phydroxyphenethylβ-D-glucoside; SAL) has various biological and pharmacological activities, including anti-inflammatory, -oxidant, and -cancer activities. However, the therapeutic effect and underlying molecular mechanism of SAL in NASH remain to be further clarified. MetHoDS aND ReSUltS:In this study, we found that SAL alleviated lipid accumulation and inflammatory response in primary hepatocytes after palmitic acid/oleic acid (PO) stimulation. In addition, SAL effectively prevented high-fat/ high-cholesterol (HFHC)-diet-induced NASH progression by regulating glucose metabolism dysregulation, insulin resistance, lipid accumulation, inflammation, and fibrosis. Mechanistically, integrated RNA-sequencing and bioinformatic analysis showed that SAL promoted AMPK-signaling pathway activation in vitro and in vivo, and this finding was further verified by determining the phosphorylation levels of AMPK. Furthermore, the protective effects of SAL on lipid accumulation and inflammation in hepatocytes and livers induced by PO or HFHC stimulation were blocked by AMPK interruption. CoNClUSIoNS:Our studies demonstrate that SAL protects against metabolic-stress-induced NASH progression through activation of AMPK signaling, indicating that SAL could be a potential drug component for NASH therapy.

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Salidroside attenuates interleukin‐1β‐induced inflammation in human osteoarthritis chondrocytes

Cited by 19 publications

References 35 publications

<p>Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats</p>

<p>Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats</p>

Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis

Salidroside Activates the AMP‐Activated Protein Kinase Pathway to Suppress Nonalcoholic Steatohepatitis in Mice

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