2020
DOI: 10.3390/ijms21197421
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Abstract: Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological activities. The purpose here was to evaluate the effects of the intraarticular administration of a slow-releasing H2S compound (GYY-4137) on an OA experimental model. OA was induced in Wistar rats by the transection of medial collateral ligament and the removal of the medial meniscus of the left joint. The a… Show more

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Cited by 16 publications
(12 citation statements)
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“…Both treatments normalized their over-expression, establishing a causal relationship between the antiallodynic effects and the recovery of hind limb grip strength in DADS-and GYY4137-treated mice during osteoarthritis. In agreement with our results, previous studies have shown the anti-inflammatory effects induced by the knee injection of GYY4137 in another osteoarthritis pain model [35] and with the recovery of the mechanical allodynia and grip strength deficits produced by other slow-releasing H 2 S donors in MIA and complete Freund's adjuvant-induced osteoarthritis pain [36,68], as well as in animals with nerve-injury-or chemotherapy-induced neuropathic pain [24,69].…”
Section: Discussionsupporting
confidence: 93%
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“…Both treatments normalized their over-expression, establishing a causal relationship between the antiallodynic effects and the recovery of hind limb grip strength in DADS-and GYY4137-treated mice during osteoarthritis. In agreement with our results, previous studies have shown the anti-inflammatory effects induced by the knee injection of GYY4137 in another osteoarthritis pain model [35] and with the recovery of the mechanical allodynia and grip strength deficits produced by other slow-releasing H 2 S donors in MIA and complete Freund's adjuvant-induced osteoarthritis pain [36,68], as well as in animals with nerve-injury-or chemotherapy-induced neuropathic pain [24,69].…”
Section: Discussionsupporting
confidence: 93%
“…Thus, considering that one of the main causes of the pathogenesis of osteoarthritis and its associated comorbidities is generated by oxidative stress, PI3K/p-AKT activation, and pro-inflammatory and pro-apoptotic responses [11,25,27], their inhibition with DADS and GYY4137 might possibly explicate their anxiolytic and antidepressant actions in this pain model. These results correspond with other data showing that most of the therapeutic actions of H 2 S may be carried out, at least in part, by reducing reactive oxygen species expression and PI3K/p-Akt/Bcl-2 pathway activation, thus preventing cell apoptosis [35,60,61]. The fact that both treatments inhibited 4-HNE overexpression and the anxiodepressive-like behaviors concurrent with chronic osteoarthritis pain supports the relationship between these disorders and oxidative stress in the amygdala [20,62].…”
Section: Discussionsupporting
confidence: 90%
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“…Nevertheless, inorganic salts, such as sodium hydrosulfide and sodium sulfide, are limited due to quick evaporation and loss of H 2 S after preparation in aqueous solutions, as well as rapid and almost instantaneous H 2 S release after in vivo injection. Alternatively, small molecular diallyl trisulfide (DATS) [ [15] , [16] , [17] ] and GYY-4137 [ 18 , 19 ], etc . [ 20 ] were synthesized and used in the studies on biological activities of H 2 S. However, H 2 S release from these donors are mostly based on a general hydrolysis mechanism, lacking of specificity or responsiveness to in vivo biological biomarkers.…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies reported that several H 2 S donors exhibited anti-inflammatory effects via HO-1 induction in different OA models [75][76][77]. Considering the strong induction of HO-1 in response to P*, we studied the possible role of HO-1 in P*-mediated downregulation of IL-6.…”
Section: Discussionmentioning
confidence: 99%