Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs

Hu, Rong; Wang, Mingqing; Ni, Shi-Hao; Wang, Ming; Liu, Lingyu; You, Hyun Ju; Wu, Xiaohui; Wang, Yanjing; Lu, Lu; Wei, Lianbo

doi:10.1016/j.ejphar.2019.172797

Cited by 151 publications

(89 citation statements)

References 52 publications

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“… Adaptogens downregulate NF‐kB translocation and expression, NF‐kB signaling, and NF‐kB mediated inflammation 326,336,434,436,437,441,545–560 ; adaptogens downregulate Fos and Jnk, the components of AP‐1 transcription factor (Table 9), which regulates many genes involved in cell proliferation, migration, ROS production, and extracellular matrix degradation 17,502,561 ; adaptogens switch FoxO‐dependent responses from apoptosis promotion to stress‐resistance in response to oxidative stress 95 ; and adaptogens activate Nrf2 signaling. Normally, Nrf2 is located in bound form in the cytosol with reduced kelch‐like ECH‐associated protein 1 (Keap1).…”

Section: Core Rational Of the Adaptogenic Conceptmentioning

confidence: 99%

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Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Panossian¹,

Efferth

Shikov

et al. 2020

Medicinal Research Reviews

198

124

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Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern rationale for their use in the treatment of stress‐induced and aging‐related disorders. Adaptogens have pharmacologically pleiotropic effects on the neuroendocrine‐immune system, which explain their traditional use for the treatment of a wide range of conditions. They exhibit a biphasic dose‐effect response: at low doses they function as mild stress‐mimetics, which activate the adaptive stress‐response signaling pathways to cope with severe stress. That is in line with their traditional use for preventing premature aging and to maintain good health and vitality. However, the potential of adaptogens remains poorly explored. Treatment of stress and aging‐related diseases require novel approaches. Some combinations of adaptogenic plants provide unique effects due to their synergistic interactions in organisms not obtainable by any ingredient independently. Further progress in this field needs to focus on discovering new combinations of adaptogens based on traditional medical concepts. Robust and rigorous approaches including network pharmacology and systems pharmacology could help in analyzing potential synergistic effects and, more broadly, future uses of adaptogens. In conclusion, the evolution of the adaptogenic concept has led back to basics of TMS and a new level of understanding of holistic approach. It provides a rationale for their use in stress‐induced and aging‐related diseases.

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Section: Core Rational Of the Adaptogenic Conceptmentioning

confidence: 99%

“…Adaptogens downregulate NF‐kB translocation and expression, NF‐kB signaling, and NF‐kB mediated inflammation 326,336,434,436,437,441,545–560 ;…”

Section: Core Rational Of the Adaptogenic Conceptmentioning

confidence: 99%

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Panossian¹,

Efferth

Shikov

et al. 2020

Medicinal Research Reviews

198

124

View full text Add to dashboard Cite

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“…Fourteen iridoids were identified in this study, corresponding to compounds 1,2,3,7,9,11,15,18,20,22,25,33,53, and 76 in Figure 2, and the mass spectrum information in Table 1. Among them, geniposidic acid (chromatographic peak No.…”

Section: Characterization Of Iridoidsmentioning

confidence: 89%

“…The asterisk marks are characteristic fragment ionsions of these six compounds, the phenylethanol parent nucleus fragment ion after the glycoside bond is broken is the characteristic fragment ion of phenylethanoid glycosides. The ingredients, such as salidroside, have anti-inflammatory and antioxidant effects and play an important role in the treatment of vascular dysfunction[33].…”

mentioning

confidence: 99%

Rapid characterization of the chemical constituents of Duzhong Jiangya tablet by HPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry

Wang

et al. 2020

J of Separation Science

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Duzhong Jiangya tablet is a hypotensive drug. In this study, high-performance liquid chromatography-Fourier transform-ion cyclotron resonance-mass spectrometry technology was used to quickly identify its chemical composition. SinoChrom ODS-BP column (250 mm × 4.6 mm, 5 μm) was used. The mobile phase was acetonitrile(A)-0.1% formic acid solution(B). The flow rate was 1 mL/min. Extracted ion chromatogram was used to analyze the samples in positive and negative ion modes. Based on the accurate mass spectrometry information (such as quasi-molecular ions and fragment ions) obtained from the instrument, combined with reference compounds and literature, the chemical composition of Duzhong Jiangya Tablets was identified. A total of 131 compounds were identified, including four types of penylpropanoids, six types of phenylethanoid glycosides, 10 types of organic acids, 14 types of iridoids, 12 types of lignans, 18 types of alkaloids, seven types of coumarins, and 60 kinds of flavonoids. This established method can quickly and efficiently identify chemical constituents in Duzhong Jiangya tablet, lay a foundation for the research on the efficacy and quality of this traditional Chinese medicine, and provide a reference for the characterization of the chemical constituents of other traditional Chinese medicine preparations. K E Y W O R D S chemical composition, Duzhong Jiangya Tablet, Fourier transform ion cyclotron resonance, traditional Chinese medicine 1 INTRODUCTION Varieties of medicinal materials in traditional Chinese medicine compound preparations have complex chemical components. The synergy between the chemical components is the material basis for the traditional Chinese medicine preparations to exert their pharmaco-Article Related Abbreviations: ICR, ion cyclotron resonance logical effects [1]. The active ingredients of most Chinese medicines are still unknown, although there are many reports on Chinese medicine research. Therefore, it is very important to establish a fast and efficient method to identify the chemical components in traditional Chinese medicine. This can reasonably explain the material basis of the efficacy of traditional Chinese medicine. Duzhong Jiangya Tablet consists of Eucommia ulmoides Oliv, Leonurus japonicus Houtt, Prunella vulgaris L,

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“…AMPK is widely expressed in the endothelium, and modulates vascular functions via both endothelium-dependent and -independent mechanisms (39). Previous reports have indicated that activation of the AMPK signaling pathway could serve an important role in the amelioration of endothelial inflammation and barrier dysfunction (40,41). Hence, the AMPK signaling pathway and the cis-targets adrenoceptor alpha 1A, tuberous sclerosis 2 and stearoyl-CoA desaturase (SCD) that are enriched in it, as well as the corresponding DELs, lnc-PNMA2-5:1, ENST00000570072 and lnc-SCD-1:8, may serve a role in the alleviation of inflammatory damage in HUVECs via Bak-IIIa.…”

Section: Discussionmentioning

confidence: 99%

Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294

Feng

et al. 2021

Mol Med Rep

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Inflammation, which causes injury to vascular endothelial cells, is one of the major factors associated with atherosclerosis (AS); therefore, inhibition of endothelial inflammation is a key step toward preventing AS. The present study aimed to investigate the effects of bakkenolide-IIIa (Bak-IIIa), an important active component of bakkenolides, on endothelial inflammation, as well as the mechanisms underlying such effects. Lipopolysaccharide (LPS)-dama ged human umbilical vein endothelial cells (HUVECs) were treated with Bak-IIIa. The results of the MTT assay and enzyme-linked immunosorbent assay indicated that Bak-IIIa significantly alleviated survival inhibition, and decreased the levels of LPS-induced TNF-α, interleukin (IL)-1β, IL-8, and IL-6. Furthermore, long noncoding RNA (lncRNA) microarray analyses revealed 70 differentially expressed lncRNAs (DELs) in LPS-damaged HUVECs treated with Bak-IIIa. lncRNA target prediction results revealed that 44 DELs had 52 cis-targets, whereas 12 DELs covered 386 trans-targets. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analyses of the trans-targets indicated that three GO terms were associated with inflammation. Therefore, 17 targets involved in these GO terms and six relevant DELs were screened out. Validation via reverse transcription-quantitative PCR indicated that the fold change of NR_015451 (LINC00294) was the highest among the six candidates and that overexpression of LINC00294 significantly alleviated LPS-induced survival inhibition and inflammatory damage in HUVECs. In conclusion, Bak-IIIa ameliorated LPS-induced inf lammatory damage in HUVECs by upregulating LINC00294. Thus, Bak-IIIa exhibited potential for preventing vascular inflammation.

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Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs

Cited by 151 publications

References 52 publications

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Rapid characterization of the chemical constituents of Duzhong Jiangya tablet by HPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry

Bakkenolide‑IIIa ameliorates lipopolysaccharide‑induced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294

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