Salicylic Acid (SA) Bioaccessibility from SA-Based Poly(anhydride-ester)

Rogers, Michael A.; Yan, Yim-Fan; Ben-Elazar, Karen; Lan, Yaqi; Faig, Jonathan J.; Smith, Kervin; Uhrich, Kathryn E.

doi:10.1021/bm500927r

Cited by 19 publications

(15 citation statements)

References 27 publications

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“…64 To further investigate SA release, SA bioaccessibility was assessed using a dynamic in vitro gastrointestinal model (TIM-1). 65 Here, SA bioaccessibility from SA-based (diglycolic) PAEs was approximately 21% over 5 hours of simulated digestion.…”

Section: Anti-inflammatory Drugsmentioning

confidence: 82%

Polyactives: controlled and sustained bioactive release via hydrolytic degradation

Stebbins

Faig

et al. 2015

Biomater. Sci.

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Significant and promising advances have been made in the polymer field for controlled and sustained bioactive delivery. Traditionally, small molecule bioactives have been physically incorporated into biodegradable polymers; however, chemical incorporation allows for higher drug loading, more controlled release, and enhanced processability. Moreover, the advent of bioactive-containing monomer polymerization and hydrolytic biodegradability allows for tunable bioactive loading without yielding a polymer residue. In this review, we highlight the chemical incorporation of different bioactive classes into novel biodegradable and biocompatible polymers. The polymer design, synthesis, and formulation are summarized in addition to the evaluation of bioactivity retention upon release via in vitro and in vivo studies.

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Section: Anti-inflammatory Drugsmentioning

confidence: 82%

Polyactives: controlled and sustained bioactive release via hydrolytic degradation

Stebbins

Faig

et al. 2015

Biomater. Sci.

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“…The rapid release of SA may be desired for antimicrobial and anti-inflammatory applications, such as treatment of infections. Whereas release is totally dependent on the encapsulating matrix, the bioaccessibility of SA can be modified in the encapsulation process since it is related to and dependent on the chemical interaction between SA and the matrix 36,39…”

Section: Introductionmentioning

confidence: 99%

Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid

Bronze‐Uhle¹,

Costa²,

Ximenes³

et al. 2016

NSA

122

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Bovine serum albumin (BSA) is highly water soluble and binds drugs or inorganic substances noncovalently for their effective delivery to various affected areas of the body. Due to the well-defined structure of the protein, containing charged amino acids, albumin nanoparticles (NPs) may allow electrostatic adsorption of negatively or positively charged molecules, such that substantial amounts of drug can be incorporated within the particle, due to different albumin-binding sites. During the synthesis procedure, pH changes significantly. This variation modifies the net charge on the surface of the protein, varying the size and behavior of NPs as the drug delivery system. In this study, the synthesis of BSA NPs, by a desolvation process, was studied with salicylic acid (SA) as the active agent. SA and salicylates are components of various plants and have been used for medication with anti-inflammatory, antibacterial, and antifungal properties. However, when administered orally to adults (usual dose provided by the manufacturer), there is 50% decomposition of salicylates. Thus, there has been a search for some time to develop new systems to improve the bioavailability of SA and salicylates in the human body. Taking this into account, during synthesis, the pH was varied (5.4, 7.4, and 9) to evaluate its influence on the size and release of SA of the formed NPs. The samples were analyzed using field-emission scanning electron microscopy, transmission electron microscopy, Fourier transform infrared, zeta potential, and dynamic light scattering. Through fluorescence, it was possible to analyze the release of SA in vitro in phosphate-buffered saline solution. The results of chemical morphology characterization and in vitro release studies indicated the potential use of these NPs as drug carriers in biological systems requiring a fast release of SA.

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“…An increasingly popular strategy is the direct incorporation of the drug into the polymer backbone containing hydrolysable bonds to aid in controlled drug release complemented with gradual degradation of the polymer. 9 A recent review discusses this important aspect of release accompanied with polymer degradation. 10 Non-steroidal anti-inflammatory drugs or NSAIDS are a class of Cox-1 and/or Cox-2 inhibitors 11 that suppress inflammation.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters

2015

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The purpose of this work was to develop a family of cross-linked poly(xylitol adipate salicylate)s with a wide range of tunable release properties for delivering pharmacologically active salicylic acid. The synthesis parameters and release conditions were varied to modulate polyester properties and to understand the mechanism of release. Varying release rates were obtained upon longer curing (35% in the noncured polymer to 10% in the cured polymer in 7 days). Differential salicylic acid loading led to the synthesis of polymers with variable cross-linking and the release could be tuned (100% release for the lowest loading to 30% in the highest loading). Controlled release was monitored by changing various factors, and the release profiles were dependent on the stoichiometric composition, pH, curing time, and presence of enzyme. The polymer released a combination of salicylic acid and disalicylic acid, and the released products were found to be nontoxic. Minimal hemolysis and platelet activation indicated good blood compatibility. These polymers qualify as "bioactive" and "resorbable" and can, therefore, find applications as immunomodulatory resorbable biomaterials with tunable release properties.

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Salicylic Acid (SA) Bioaccessibility from SA-Based Poly(anhydride-ester)

Cited by 19 publications

References 27 publications

Polyactives: controlled and sustained bioactive release via hydrolytic degradation

Polyactives: controlled and sustained bioactive release via hydrolytic degradation

Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid

Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters

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