Salicylic acid and some of its derivatives as antibacterial agents for viscose fabric

Kantouch, A.; El‐Sayed, A. Atef; Salama, M. A.; El‐Kheir, Amira Abou; Mowafi, Salwa

doi:10.1016/j.ijbiomac.2013.09.021

Cited by 38 publications

(25 citation statements)

References 19 publications

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“…The combination of different compounds within the same formulation generally pursues a synergistic effect that could allow the reduction of the concentration of each one, and thus their potential adverse effects; however, other benefits from such an approach might be the combination of other functional properties such as, in this case, the ones introduced previously, which are also related to treating psoriasis and other factors such as their antimicrobial activities [56,57].…”

Section: Resultsmentioning

confidence: 99%

Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment

et al. 2019

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Psoriasis is a chronic autoimmune systemic disease with an approximate incidence of 2% worldwide; it is commonly characterized by squamous lesions on the skin that present the typical pain, stinging, and bleeding associated with an inflammatory response. In this work, poly(methyl vinyl ether-alt-maleic ethyl monoester) (PMVEMA-ES) nanofibers have been designed as a delivery vehicle for three therapeutic agents with palliative properties for the symptoms of this disease (salicylic acid, methyl salicylate, and capsaicin). For such a task, the production of these nanofibers by means of the electrospinning technique has been optimized. Their morphology and size have been characterized by optical microscopy and scanning electron microscopy (SEM). By selecting the optimal conditions to achieve the smallest and most uniform nanofibers, approximate diameters of up to 800–900 nm were obtained. It was also determined that the therapeutic agents that were used were encapsulated with high efficiency. The analysis of their stability over time by GC-MS showed no significant losses of the encapsulated compounds 15 days after their preparation, except in the case of methyl salicylate. Likewise, it was demonstrated that the therapeutic compounds that were encapsulated conserved, and even improved, their capacity to activate the transient receptor potential cation channel 1 (TRPV1) channel, which has been associated with the formation of psoriatic lesions.

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Section: Resultsmentioning

confidence: 99%

Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment

et al. 2019

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“…The results have shown a remarkable antibacterial activity of 5-chlorosalicylic acid against Escherichia coli . [ 21 ] Therefore, this acid (ligand) could contribute to the antibacterial properties of silver complexes.…”

Section: Resultsmentioning

confidence: 99%

Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects

et al. 2018

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The antibacterial effects against Staphylococcus epidermidis of five silver carboxylate complexes with anti-inflammatory ligands were studied in order to analyze and compare them in terms of stability (in solution and after exposure to UV light), and their antibacterial and morphological differences. Four effects of the Ag-complexes were evidenced by transmission electronic microscopy (TEM) and scanning electronic microscopy (SEM): DNA condensation, membrane disruption, shedding of cytoplasmic material and silver compound microcrystal penetration of bacteria. 5-Chlorosalicylic acid (5Cl) and sodium 4-aminosalicylate (4A) were the most effective ligands for synthesizing silver complexes with high levels of antibacterial activity. However, Ag-5Cl was the most stable against exposure UV light (365 nm). Cytotoxic effects were tested against two kinds of eukaryotic cells: murine fibroblast cells (T10 1/2) and human epithelial ovarian cancer cells (A2780). The main objective was to identify changes in their antibacterial properties associated with potential decomposition and the implications for clinical applications.

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“…In few cases, it has been noticed that the drug activity increases, when SA is administered as metal chelates, for instance in the inhibition of the growth of tumor cells (Brumas, 1995;Brumas, 2007 andWani et al 2017b). Quoting an example, the mono and di-substituted chloro-derivatives of salicylic acid have been shown to be biologically active (Kantouch et al 2013 andShi et al 2007). In relation to its interaction with proteins, it has been observed that the SA and its derivatives possess low to medium covalent interaction with proteins like human serum albumin (HSA) and bovine serum albumin (BSA) (Kumar et al 2015a; Yin et al 2007 andLi et al 2011), that is known to be one of the most abundant proteins in blood and cerebrospinal fluid, playing a fundamental role in the distribution of essential transition metal ions across different parts of the human body.…”

Section: Introductionmentioning

confidence: 99%

Complexation of trichlorosalicylic acid with alkaline and first row transition metals as a switch for their antibacterial activity

Kumar

Chawla

Cavallo

et al. 2018

Inorganica Chimica Acta

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CitationKumar V, Chawla M, Cavallo L, Basit Wani A, Manhas A, et al. (2017) Complexation of trichlorosalicylic acids by alkaline and first row transition metals as a switch for their antibacterial activity. Inorganica Chimica Acta. Available: http:// dx.NirajUpadhyay, Complexation of trichlorosalicylic acids by alkaline and first row transition metals as a switch for their antibacterial activity, Inorganica Chimica Acta (2017), doi: http://dx. Abstract:3,5,6-trichlorosalicylic acid (TCSA) does not show a good antibacterial activity. In contrast, here metal complexes with TCSA have shown better antibacterial activity for selected bacterial strains with a good degree of selectivity. Amongst the eight synthesized essential metal complexes complexed with TCSA, Mn(II)-TCSA and Ni(II)-TCSA have been found to be more effective with MIC range 20-50 µg/L as compared to control (chloramphenicol). The activity of an individual complex against different microbes was not found to be identical, indicating the usage of an individual metal chelate against a targeted bacterial strain. Further, the protein (BSA) binding constant of TCSA and its metal complexes were determined and ordered as Ca(II)-TCSA > Cu(II)-TCSA > Mg(II)-TCSA >> Mn(II)-TCSA >> Zn(II)-TCSA >>> Ni(II)-TCSA >>> Co(II)-TCSA > Fe(II)-TCSA > TCSA. The present study has confirmed enhanced antibacterial activities and binding constants for metal chelates of TCSA as compared to free TCSA, which seems directly related with the antioxidant activities of these complexes. Further, bearing the ambiguity related to the structural characterization of the metal complexed with TCSA ligands, DFT calculations have been used as the tool to unravel the right environment around the metals, studying basically the relative stability of square planar and octahedral metal complexes with TCSA.

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Salicylic acid and some of its derivatives as antibacterial agents for viscose fabric

Cited by 38 publications

References 19 publications

Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment

Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment

Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects

Complexation of trichlorosalicylic acid with alkaline and first row transition metals as a switch for their antibacterial activity

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