Complexation of trichlorosalicylic acid with alkaline and first row transition metals as a switch for their antibacterial activity

Abstract

CitationKumar V, Chawla M, Cavallo L, Basit Wani A, Manhas A, et al. (2017) Complexation of trichlorosalicylic acids by alkaline and first row transition metals as a switch for their antibacterial activity. Inorganica Chimica Acta. Available: http:// dx.NirajUpadhyay, Complexation of trichlorosalicylic acids by alkaline and first row transition metals as a switch for their antibacterial activity, Inorganica Chimica Acta (2017), doi: http://dx. Abstract:3,5,6-trichlorosalicylic acid (TCSA) does not show a good antibacterial activity. In contrast, here metal complexes with TCSA have shown better antibacterial activity for selected bacterial strains with a good degree of selectivity. Amongst the eight synthesized essential metal complexes complexed with TCSA, Mn(II)-TCSA and Ni(II)-TCSA have been found to be more effective with MIC range 20-50 µg/L as compared to control (chloramphenicol). The activity of an individual complex against different microbes was not found to be identical, indicating the usage of an individual metal chelate against a targeted bacterial strain. Further, the protein (BSA) binding constant of TCSA and its metal complexes were determined and ordered as Ca(II)-TCSA > Cu(II)-TCSA > Mg(II)-TCSA >> Mn(II)-TCSA >> Zn(II)-TCSA >>> Ni(II)-TCSA >>> Co(II)-TCSA > Fe(II)-TCSA > TCSA. The present study has confirmed enhanced antibacterial activities and binding constants for metal chelates of TCSA as compared to free TCSA, which seems directly related with the antioxidant activities of these complexes. Further, bearing the ambiguity related to the structural characterization of the metal complexed with TCSA ligands, DFT calculations have been used as the tool to unravel the right environment around the metals, studying basically the relative stability of square planar and octahedral metal complexes with TCSA.

Determination of phytochemical, antioxidant, antimicrobial, and protein binding qualities of hydroethanolic extract of Celastrus paniculatus

“…Since the medicines form various plants have significant influence on protein-binding properties. The interesting point of the study is that extract under study has shown least binding rate with BSA protein as compared to acetylsalicylic acid, which is the feature of good medicines [21,22]. However, complexation with albumin proteins can stabilize the medicines against aggregation, leading to retention of the antimicrobial activities .…”

“…Quantitative analysis of TFC and TPC was analyzed as per the protocols explained in literature [11][12][13][14][15][16][17]. Protein binding and binding constant calculations of drugs under the study were performed by well-described methods in literature [18][19][20][21][22]. Anti-inflammatory assay was performed by following the bovine serum albumin (BSA) protein method [9][10][11].…”

Spectral, structural and energetic study of acephate, glyphosate, monocrotophos and phorate: an experimental and computational approach

“…In spectroscopic analysis, very good agreement between computational and experimental data was observed. The negotiable differences were observed because theoretical calculations were performed in the gaseous phase, while the experimental results were obtained in the solid/liquid phase [32][33][34][35][36][37][38]. Excellent results were obtained for UV-visible analysis, where negligible difference was observed between the computational and experimental analysis.…”

“…The higher difference (>20 cm −1 ) was observed at the N-H frequencies of molecules 3. It was due to the involvement of N-H in resonance with C9O [34][35][36][37]. There was less than 20 cm −1 difference observed in the P-O frequency molecule 4.…”

“…The reasons behind it were very much similar as discussed in the UV and FTIR section. The additional fact was the influence of solvent with molecule(s) [33][34][35][36][37][38].…”