Salicylic Acid

Two New Biologically Active Triterpenoidal Saponins Acylated with Salicylic Acid from Albizia adianthifolia

“…The sugars obtained from the saponin hydrolysate were identified as glucose, fucose, rhamnose, arabinose, and xylose, by comparison with authentic samples on TLC. Alkaline hydrolysis of 2 afforded salicylic acid ( 7 ), identified by comparison of its 1 H and 13 C NMR data with those reported, and a prosapogenin ( 5 ), whose NMR data were almost similar to those of the prosapogenin previously isolated from the alkaline hydrolysate of the Albizia cortex saponin mixture . The above data suggested that 2 should be a 21-acyl-3,28- O -bisdesmoside.…”

“…The combined Et 2 O extracts were washed (H 2 O). Evaporation of the Et 2 O layer yielded salicylic acid 7 (1 mg) (TLC, 13 C NMR), identified by comparison with literature data, whereas evaporation of the n -BuOH extract yields the prosapogenin 4 (3 mg) (TLC, 13 C NMR) from 1 , which was identified by comparison of its spectral data with those reported in the literature, and a prosapogenin 5 (2.5 mg) from 2 , previously isolated from the alkaline hydrolysate of the crude saponin mixture of Albizia cortex by comparison of its spectral data with those reported in the literature …”

“…However, the presence of an N -acetamido group [IR 1639 and 1570 cm -1 ; 1 H NMR δ H 2.13 (3H, s, Me CO) and δ H 8.91 (1H, d, J = 8.8 Hz, N H ); 13 C NMR δ C 22.9 and 171.9], together with the 1 H and 13 C NMR data of the C-2 of the Glc 1 (δ H 4.40 and δ C 56.8), suggested the presence of one 2-(acetylamino)-2-deoxyglucose (Glc 1 NAc) unit. In addition, alkaline hydrolysis of 1 afforded salicylic acid (SA, o -hydroxybenzoic acid, 7 ), identified by comparison of its 1 H and 13 C NMR data with those reported, and a prosapogenin whose spectroscopic NMR data were in good agreement with those of 4 . The above data suggested that 1 is a 21-acyl-3,28-bisdesmoside.…”

A Process Analytical Technology approach to near-infrared process control of pharmaceutical powder blending. Part I: D-optimal design for characterization of powder mixing and preliminary spectral data evaluation

“…A standard assay method for SA was adopted, with slight modification 19. To dissolve the active, the weighed powder samples were mixed with 10 ml of methanol, followed by dilution with distilled water to 100 ml.…”

A prospective, randomized, split‐face study of concomitant administration of low‐dose oral isotretinoin with 30% salicylic acid chemical peeling for the treatment of acne vulgaris in Asian population

“…Salicylic acid (SA) is one of the most frequently used peeling agents due to its keratinolytic, anti‐inflammatory, and anti‐infective properties 11–16 . However, traditional synthetic SA is hard to be dissolved in water and thus forms white fine needle crystals, 17 a frequent option was to solve it into an organic solvent, ethanol, for instance to increase its solubility. However, either the needle‐shaped precipitation or alcoholic solution causes skin irritation, which impedes the application of SA.…”