Salicylates, Oligoantigenic Diets, and Behaviour

Nutritional and dietary influences on attention deficit hyperactivity disorder

“…Behavioral reactions to food substances are associated with pharmacological rather than allergic mechanisms, although it is possible that these reactions coexist 79 . Underlying mechanisms for behavioral food reactions are not entirely clear.…”

“…Feingold reported that more than half of children who adhered to his elimination diet responded favorably and that many children's behavioral symptoms reached the normal range. It has since been discovered, however, that many of the foods in his diet contained salicylates, and that many of these children also react to other food components such as food coloring 79 . The complexities of dietary intervention, most notably the large variety of potentially suspect food substances and individual differences in the nature and dosage of the food intolerance, resulted in inconsistencies in subsequent research trials.…”

Treatment-Resistant Depression: When Antidepressant Drug Intolerance May Indicate Food Intolerance

“…Such judgements are more likely if testing is for immunological food allergy alone [7], an elimination diet is not trialled before challenging, if elimination diets containing significant amounts of chemicals shown to be associated with symptoms (such as salicylates) are not employed [8], or if the possibility that reactions to foods can be delayed for days [2] is not recognized. Such judgements are more likely if testing is for immunological food allergy alone [7], an elimination diet is not trialled before challenging, if elimination diets containing significant amounts of chemicals shown to be associated with symptoms (such as salicylates) are not employed [8], or if the possibility that reactions to foods can be delayed for days [2] is not recognized.…”

Simultaneous determination of gentisic, salicyluric and salicylic acid in human plasma using solid-phase extraction, liquid chromatography and electrospray ionization mass spectrometry

“…Gentisic (GA) and salicylic acid (SA) is a normal constituent in human plasma because of the fact that salicylic acid (SA) can be found in a large number of foods such as cucumber, melon, cherry, etc. [23]. In this paper, it is shown that the validated method requires decreased sample preparation time, offers higher sensitivity at analysis times <15 min.…”