Salicylates Increase Insulin Secretion in Healthy Obese Subjects

Abstract

The administration of a salicylate compound led to lowering of serum glucose concentration. We suggest that this effect was mediated through increased insulin secretion induced by salicylate directly on the beta-cell.

Skeletal muscle inflammation is not responsible for the rapid impairment in adiponectin response with high-fat feeding in rats

“…Additional conflicting results have been reported in humans following aspirin and salicylate derivative supplementation. Evidence of improved (10), unchanged (9,18,29), and decreased (2, 4, 13, 27) insulin sensitivity have all been reported following salicylate supplementation at doses (1-7 g/day in adult humans) and time periods (3 days to 4 wk), similar to the current study. In the current study, plasma ASA levels in supplemented animals averaged ϳ2 mM, consistent with previously reported levels in humans and animals (range 1-5 mM) and well below toxic levels (45,46).…”

Therapeutic Methods Against Insulin Resistance

“…This pancreatic ischemia caused by atherosclerotic plaques located at the mouth of the celiac trunk and its branches may be improved through two procedures: first, high-dose aspirin to increase the blood flow (recanalization) in the pancreas and thus, increase insulin secretion, based on its anti-inflammatory, anti-platelet and anti-thrombotic actions [17,18,[65][66][67][68], and second, omental transposition (pedicled graft) on the pancreas in order to revascularize the islets of Langerhans and provide stem cells from the omentum [14,70,71]. Through these two procedures, we could improve the function of the exocrine and endocrine pancreas.…”

“…However, unlike other challenging diseases [4,6], I believe that this disease is initiated in the anterior hypothalamus by ischemia, and years later, continued by pancreatic ischemia and insulin resistance [12][13][14]. The vascular impairment in the hypothalamus and pancreas can be improved by means of recanalization [15][16][17][18] or revascularization [2,13,14,19]; meanwhile, the treatment of insulin resistance continues to be a challenge. Thus, in this review article, I analyze three key factors involved in the pathogenesis of type 2 DM, but especially of insulin resistance.…”

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

“…The first clinical trials with high dose (≥3 g) salsalate or the salicylate derivative trifusal indeed showed that fasting glucose levels decreased in nondiabetic, mostly obese, persons while insulin concentrations increased in the context of reduced insulin clearance [90][91][92]. In a pilot trial of 7 g aspirin/day for 2 weeks in nine patients with type 2 diabetes, similar changes were observed, with mean fasting plasma glucose levels falling from 9.1 to 6.9 mmol/l [93].…”