Safranal of <scp><i>Crocus sativus</i></scp> L. Inhibits Inducible Nitric Oxide Synthase and Attenuates Asthma in a Mouse Model of Asthma

Bukhari, Syed Imran; Pattnaik, Bijay; Rayees, Sheikh; Kaul, Sanjana; Dhar, Manoj K.

doi:10.1002/ptr.5315

Cited by 46 publications

(38 citation statements)

References 36 publications

(61 reference statements)

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“…Farahmand et al (2013) stated that safranal could be effective as a hormetin and in cases of mild oxidative damage that causes the activation of the antioxidative enzymes. Several studies that investigated the anti-inflammatory and antioxidant potentials of safranal reported a decrease in NO x level due to safranal administration (Samarghandian et al, 2014;Bukhari et al, 2015;Hazman and Bozkurt 2015). In the present study, decreased NO x levels in the T+S group indicated that safranal decreased the thinner-based stressors.…”

Section: Discussionsupporting

confidence: 62%

Effects of Safranal on Tissue Oxidative Stress in Sub-Chronic Thinner-Addicted Rats

Duz

Fidan

2020

J Hellenic Vet Med Soc

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The present study was carried out to determine the effects of sub-chronic thinner addiction on the oxidant-antioxidant balance and oxidative stress on certain tissues and the possible protective effect of safranal against thinner toxication in rats. Adult male Wistar albino rats were randomly divided into four groups of 10 animals each as follows: control (C), safranal (S), thinner (T) and thinner+safranal (T+S). The control group received 1cc saline by gastric gavage. Safranal was administered to S and T+S groups by using gastric gavage at a dose of 100 mg/kg/day and volume of 0.1 mL/kg/day. Thinner inhalation was applied to T and T+S groups in a container with NaOH tablets twice a day. Levels of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO x ) metabolites, total antioxidant capacity (TAS) and total oxidant capacity (TOS) were determined in liver, lung, brain, kidney and testis tissues of the rats. In the T+S group, it was observed that the MDA levels significantly decreased in all tissues, except the kidney, in comparison to the thinner inhalation group (p = 0.000). When the NOx levels of the T+S group were compared with the levels of the T group, it was concluded that there existed a statistically significant decrease in the NOx levels in all tissues (p = 0.000).In T+S group, it was observed that safranal either eliminated or mitigated oxidative stress that developed in tissues through decreasing MDA and TOS levels and increasing GSH and TAS levels and caused significant decreases in NO X levels in all tissues. As a result, it was determined that safranal, although not uniform for all tissue types, had a protective potential against the damaging effects of oxidative stress caused by sub-chronic thinner inhalation.

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Section: Discussionsupporting

confidence: 62%

Effects of Safranal on Tissue Oxidative Stress in Sub-Chronic Thinner-Addicted Rats

Duz

Fidan

2020

J Hellenic Vet Med Soc

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“…C . sativus decreased NO, iNOS levels, peroxynitrite ion generation, and prevented cytochrome c release (Bukhari et al ., ). Bayrami et al indicated that treatment of sensitized guinea‐pigs with saffron resulted in a significant decrease in serum NO and nitrite levels.…”

Section: Methodsmentioning

confidence: 97%

Antiinflammatory, Antioxidant, and Immunomodulatory Effects ofCrocus sativusL. and its Main Constituents

2016

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Crocus sativus L. (C. sativus), commonly known as saffron, is used as a food additive, preservative, and medicinal herb. Traditionally, it has been used as an alternative treatment for different diseases. C. sativus' medicinal effects are related to its major constituents like crocins, crocetin, and safranal. According to the literature, C. sativus and its constituents could be considered as an effective treatment for neurodegenerative disorders, coronary artery diseases, asthma, bronchitis, colds, fever, diabetes, and so on. Recently, numerous studies have reported such medicinal properties and found that the underlying mechanisms of action may be mediated by antioxidant, inflammatory, and immunomodulatory effects. C. sativus enhances the antioxidant capacity and acts as a free radical scavenger. As an antiinflammatory and immunomodulatory agent, it modulates inflammatory mediators, humoral immunity, and cell-mediated immunity responses. This review highlights in vitro and animal findings regarding antiinflammatory, antioxidant, and immunomodulatory effects of C. sativus and its constituents. Present review found that the C. sativus and its main constituents such as safranal, crocins, and crocetin could be effective against various diseases because of their antioxidant, anti-inflammation, and immunomodulatory effects. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Allium cepa extract and quercetin also showed protective effect in a mice model of asthma (254). Crocus sativus , a natural antioxidant, and its main constituents, safranal and crocin, have shown the protective effects against the oxidative stress in the mice model of asthma (255). Resveratrol, a well-known antioxidant, has also shown its protective effects in a mice model of asthma (256–258).…”

Section: Possible Therapeutic Interventions To Combat Soot- or Cb-assmentioning

confidence: 99%

The Toxicological Mechanisms of Environmental Soot (Black Carbon) and Carbon Black: Focus on Oxidative Stress and Inflammatory Pathways

2017

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The environmental soot and carbon blacks (CBs) cause many diseases in humans, but their underlying mechanisms of toxicity are still poorly understood. Both are formed after the incomplete combustion of hydrocarbons but differ in their constituents and percent carbon contents. For the first time, “Sir Percival Pott” described soot as a carcinogen, which was subsequently confirmed by many others. The existing data suggest three main types of diseases due to soot and CB exposures: cancer, respiratory diseases, and cardiovascular dysfunctions. Experimental models revealed the involvement of oxidative stress, DNA methylation, formation of DNA adducts, and Aryl hydrocarbon receptor activation as the key mechanisms of soot- and CB-induced cancers. Metals including Si, Fe, Mn, Ti, and Co in soot also contribute in the reactive oxygen species (ROS)-mediated DNA damage. Mechanistically, ROS-induced DNA damage is further enhanced by eosinophils and neutrophils via halide (Cl− and Br−) dependent DNA adducts formation. The activation of pulmonary dendritic cells, T helper type 2 cells, and mast cells is crucial mediators in the pathology of soot- or CB-induced respiratory disease. Polyunsaturated fatty acids (PUFAs) were also found to modulate T cells functions in respiratory diseases. Particularly, telomerase reverse transcriptase was found to play the critical role in soot- and CB-induced cardiovascular dysfunctions. In this review, we propose integrated mechanisms of soot- and CB-induced toxicity emphasizing the role of inflammatory mediators and oxidative stress. We also suggest use of antioxidants and PUFAs as protective strategies against soot- and CB-induced disorders.

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Safranal of Crocus sativus L. Inhibits Inducible Nitric Oxide Synthase and Attenuates Asthma in a Mouse Model of Asthma

Cited by 46 publications

References 36 publications

Effects of Safranal on Tissue Oxidative Stress in Sub-Chronic Thinner-Addicted Rats

Effects of Safranal on Tissue Oxidative Stress in Sub-Chronic Thinner-Addicted Rats

Antiinflammatory, Antioxidant, and Immunomodulatory Effects ofCrocus sativusL. and its Main Constituents

The Toxicological Mechanisms of Environmental Soot (Black Carbon) and Carbon Black: Focus on Oxidative Stress and Inflammatory Pathways

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