Safety of rTMS to non-motor cortical areas in healthy participants and patients

Machii, Kenji; Cohen, Daniel; Ramos-Estébanez, Ciro; Pascual‐Leone, Álvaro

doi:10.1016/j.clinph.2005.10.014

Cited by 220 publications

(154 citation statements)

References 83 publications

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“…There was no significant adverse effect in our study. Low-frequency rTMS to the prefrontal area may be associated with a higher incidence of headache and neck pain (17).…”

Section: Discussionmentioning

confidence: 99%

“…Repetitive transcranial magnetic stimulation is a rapidly developing technique for the investigation of brain function, and several studies have been performed focusing on the use of rTMS to obtain clinical gains in neuropsychiatric diseases, such as major depression, Parkinson's disease, and epilepsy. As it is known, rTMS is a non-invasive, easily applicable, and relatively safe method (17). High-frequency rTMS (greater than 1 Hz) usually activates neurons and increases cerebral perfusion, whereas LF-rTMS (1 Hz or less) does the opposite (18,19).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Yağcı¹,

Ağırman²,

Öztürk³

et al. 2014

Turk J Phys Med Rehab

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ÖzetAmaç: Medikal tedaviye dirençli fibromiyalji hastalarında motor korteks alana uygulanan düşük frekanslı tekrarlayıcı transkraniyal manyetik stimülasyonun (tTMS) etkinliğini araştırmak. Gereç ve Yöntemler: Toplam 25 hasta randomize olarak aktif ve plasebo gruplarına ayrılarak çalışmaya alındı. Aktif tTMS grubu için stimülasyon sol primer motor korteks üzerinden motor eşik değerin %90'ı hesaplanarak 1 Hz ve 20 dakika uygulandı. Her seansta 1200 uyarı olmak üzere, iki hafta boyunca toplam 10 seans tedavi uygulandı. Plasebo grup için, parabolik koil 90° açı ile motor kortekse yerleştirildi ve aynı şekilde toplam 10 seans stimülasyon uygulandı. Sonuçlar, ağrı için vizüel analog skalası (VAS), Fibromiyalji Etkinlik Anketi (FIQ) ve Beck Depresyon Skalası (BDS) ile değerlendirildi. Bulgular: Her iki grupta da tedavi sonunda, 1 ve 3. ay sonunda ağrı derecesinde, FIQ ve BDS'de anlamlı iyileşme gözlendi. Ancak, aktif tTMS grubunda iyileşme plasebo gruba göre daha iyiydi. Tedavi sonu FIQ skorlarında aktif grupta, plasebo gruba göre istatistiksel olarak anlamlı iyileşme gözlendi. Diğer değerlendirmelerde gruplar arasında istatistiksel farklılık saptanmadı. Sonuç: Primer motor korteks üzerine düşük doz tTMS uygulamasının uzun süreli takiplerde fibromiyalji hastalarında plaseboya göre anlamlı iyileşme göstermediği görülmüştür. Anahtar Kelimeler: Fibromiyalji, transkraniyal manyetik stimülasyon, ağrı AbstractObjective: To investigate the effectiveness of low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) to the motor cortex area in fibromyalgia patients who are resistant to medical treatment. Material and Methods: A total of 25 patients were randomly assigned to the study, who were in the active rTMS (n=13) or sham stimulation (n=12) group. For the rTMS group, the main stimulation parameters were 90% of motor threshold for 60 seconds at 1 Hz and a 45-second interval between each train. Ten sessions of low-frequency rTMS, which had a total of 1200 pulses at each session, were applied to the left primary motor cortex area daily over a period of 2 weeks. For the sham group, the same parabolic coil was placed at 90° angles to the motor cortex area, and the patients received 10 sessions of sham stimulation. The outcome parameters were pain intensity, which was measured by visual analog scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), and the Beck Depression Inventory (BDI). Results: A significant improvement in pain intensity, FIQ, and BDI scores was seen at the 10 th day and first and third months in both groups. Although the mean of parameters of the rTMS groups was better than the sham group, the difference did not reach statistical significance, except FIQ scores at the 10 th day in the real rTMS group. Conclusion: Patients with fibromyalgia who enroll in real TMS did not present significant differences in long-term follow-ups with respect to those who enrolled in the sham TMS group.

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“…There was no significant adverse effect in our study. Low-frequency rTMS to the prefrontal area may be associated with a higher incidence of headache and neck pain (17).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Yağcı¹,

Ağırman²,

Öztürk³

et al. 2014

Turk J Phys Med Rehab

View full text Add to dashboard Cite

show abstract

“…The most serious adverse event of TMS is the risk of triggering epileptic seizures (Bostrom and Sandberg 2009) which can be less than 1/1000 (Machii, et al 2006) in healthy subjects (Machii et al 2006;Rossi et al 2009;Krishnan et al 2015). In this study, we used previously established safe TMS protocols (10 Hz frequency; 100 % motor threshold intensity; long inter-train interval).…”

Section: Discussionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

et al. 2016

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“…The purpose of the screening session was to locate the correct cranial target area for rTMS administration using phosphene perception as a functional marker for striate and motion-sensitive extrastriate cortex stimulation [Silvanto et al, 2005a] and then to acquire a threshold measurement of stimulation intensity subsequently used to calibrate stimulation for the testing session [Machii et al, 2006]. TMS was administered using a MagStim Rapid2 biphasic stimulator and a MagStim figure-8 air-cooled coil r Thompson et al r r 3118 r (active surface of 2 3 70 mm).…”

Section: Tmsmentioning

confidence: 99%

A double dissociation between striate and extrastriate visual cortex for pattern motion perception revealed using rTMS

Thompson

Aaen-Stockdale

Koski

et al. 2009

Human Brain Mapping

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Abstract:The neural mechanisms underlying the integration and segregation of motion signals are often studied using plaid stimuli. These stimuli consist of two spatially coincident dynamic gratings of differing orientations, which are either perceived to move in two unique directions or are integrated by the visual system to elicit the percept of a checkerboard moving in a single direction. Computations pertaining to the motion of the individual component gratings are thought to take place in striate cortex (V1) whereas motion integration is thought to involve neurons in dorsal stream extrastriate visual areas, particularly V5/MT. By combining a psychophysical task that employed plaid stimuli with 1 Hz offline repetitive transcranial magnetic stimulation (rTMS), we demonstrated a double dissociation between striate and extrastriate visual cortex in terms of their contributions to motion integration. rTMS over striate cortex increased coherent motion percepts whereas rTMS over extrastriate cortex had the opposite effect. These effects were robust directly after the stimulation administration and gradually returned to baseline within 15 minutes. This double dissociation is consistent with previous patient data and the recent hypothesis that both coherent and transparent motion percepts are supported by the visual system simultaneously and compete for perceptual dominance.

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Safety of rTMS to non-motor cortical areas in healthy participants and patients

Cited by 220 publications

References 83 publications

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

A double dissociation between striate and extrastriate visual cortex for pattern motion perception revealed using rTMS

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