Safety of nanosuspensions in drug delivery

Development of dextrin-amphotericin B formulations for the treatment of Leishmaniasis

“…Table 1 shows that the produced material is polydisperse, presenting a wide size distribution. The size of the nanocomplexes may be considered safe both for intralesional or intravenous injection, since capillary blockage and embolism is only promoted by particles with size N5 μm [32]; it has been reported that Fungizone®, which consist of particles with a mean size of 3310 nm [33], can be applied without any harmful effects [34].…”

Feasibility of USPIOs for T1-weighted MR molecular imaging of tumor receptors

“…The results indicated that the viability of the cells was not affected by the presence of the probes even up to 1.5 mM for 24 h ($95%), suggesting that similar to PAA@USPIOs demonstrated previously; 28 our probes were noncytotoxic and safe for further in vivo use. 42 This result also indicated that the surface modications did not alter the safety prole of the USPIOs.…”

Nanosuspensions as a promising approach to enhance bioavailability of poorly soluble drugs : An update

“…Nano is related to very small (nano range) and suspension is biphasic dosage form which is the combination of two phases, namely dispersed phase and another one is dispersion medium. Generally, nanosuspensions are mainly used to increase physicochemical properties as well as safety and efficacy of drugs which have low solubility 3…”