Safety of Measles-Containing Vaccines in 1-Year-Old Children

Klein, Nicola P.; Lewis, Edwin; Fireman, Bruce; Hambidge, Simon J.; Naleway, Allison L.; Nelson, Jennifer C.; Belongia, Edward A.; Yih, W. Katherine; Nordin, James D.; Hechter, Rulin C.; Weintraub, Eric; Baxter, Roger

doi:10.1542/peds.2014-1822

Cited by 39 publications

(28 citation statements)

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“…Clustering of febrile seizures in the 2 weeks following MMR containing vaccines is an expected finding, given previous studies which demonstrate an association, with the greatest risk occurring between day 5 and day 12 following vaccination [10,[13][14][15][16]. It is not possible to determine causality in this study though, especially given that half of the subjects with febrile seizure following MMR also had at least one virus identified.…”

Section: Discussionmentioning

confidence: 63%

“…Previous studies have suggested a possible role for Influenza, Adenovirus and Human Herpesvirus 6 (HHV6) [4][5][6][7][8][9]. Recent literature has focused on the possible association between febrile seizures and complications of vaccine administration, with particular emphasis on Measles-containing vaccines [10][11][12][13][14][15][16]. In Australia in 2010 there was an increase of reported incidence of children with febrile adverse events following administration of one brand of trivalent influenza vaccine (bioCSL FluVax®).…”

Section: Introductionmentioning

confidence: 99%

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An observational study of febrile seizures: the importance of viral infection and immunization

et al. 2016

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BackgroundFebrile seizures are common in young children. Annual peaks in incidence mirror increased respiratory virus activity during winter. Limited virological data are available using modern diagnostic techniques for children with febrile seizures. We aimed to determine the frequency of detection of specific viral pathogens in children with febrile seizures, to describe risk factors including recent vaccination and clinical features associated with specific etiologies.MethodsAn observational study was performed. Children aged 6 months to 5 years presenting to the Emergency Department of a tertiary children’s hospital in Western Australia with febrile seizures were enrolled between March 2012 and October 2013. Demographic, clinical data and vaccination history were collected, and virological testing was performed on per-nasal and per-rectal samples.ResultsOne hundred fifty one patients (72 female; median age 1.7y; range 6 m-4y9m) were enrolled. Virological testing was completed for 143/151 (95%). At least one virus was detected in 102/143 patients (71%). The most commonly identified were rhinoviruses (31/143, 22%), adenovirus (30/151, 21%), enteroviruses, (28/143, 20%), influenza (19/143, 13%) and HHV6 (17/143, 12%). More than one virus was found in 48/143 (34%). No significant clinical differences were observed when children with a pathogen identified were compared with those with no pathogen detected. Febrile seizures occurred within 14 days of vaccine administration in 16/151 (11%).ConclusionAt least one virus was detected in over two thirds of cases tested (commonly picornaviruses, adenovirus and influenza). Viral co-infections were frequently identified. Febrile seizures occurred infrequently following immunization.

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

An observational study of febrile seizures: the importance of viral infection and immunization

et al. 2016

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“…More serious adverse effects include seizures, which are more frequent in children with a personal or family history of febrile seizures and family history of epilepsy. Among 12– to 23‐month‐olds, vaccination with MMR and varicella leads to 1 seizure per 2300 doses, with this rate doubling for those children receiving the combined MMRV vaccine . Therefore, the MMRV vaccine is only recommended to be given as the 4– to 5‐year dose and not at 12–15 months.…”

Section: Safety Of Mmr Vaccinementioning

confidence: 99%

Measles vaccine: Past, present, and future

Zachariah

Stockwell

2015

The Journal of Clinical Pharma

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“…The Centers for Disease Control and Prevention (CDC) in the U.S. recommended 26 vaccine doses for infants in 2007 with clinical implications suggesting deleterious impacts on infants' health due to uncharacterized interference among unrelated vaccines after consecutive cycles of intensive immunization [8]. All measlescontaining vaccines are associated with several types of adverse events, including seizure, fever, and immune thrombocytopenia purpura [9]. this invasive mode invariably induces a systemic burst of overly exuberant inflammation in nearly all vaccinees shortly post-injection.…”

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confidence: 99%

Noninvasive vaccination as a casus belli to redeem vaccine value in the face of anti-vaccine movements

Tang¹

2017

Integr Mol Med

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Formidable anti-vaccine movements have been growing as a menace to disrupt beneficial vaccine programs. Although the vaccination-associated adverse effects commonly perceived by vaccine resisters usually represent over-reactions to rare manifestations, converging evidence shows that vaccination-associated health threats could be pervasive when systemic inflammation is considered as a side effect that oozes over time. An anti-vaccine movement thus may not be so unfounded even though the myriad cascades triggered by systemic inflammation have not been brought to a clear focus during any anti-vaccine campaign. Since both pro-and antivaccine groups are acting on the same primal impulse -"keep people healthy," reconciliation between the two warring factions should be achievable on a palatable trend that fosters the development of noninvasive vaccines which tend to induce local and transient inflammation along the interface with diminished potential to percolate through internal organs. Anti-vaccine movements fueled by vaccines' incertitudeVaccination is widely heralded as a medical paradigm credited with mitigation of many vaccination-preventable diseases through massimmunization programs. However, its success has also precipitated an active opposition. The genesis of the anti-vaccine movement surge could be traced back to the anti-vaccine sentiment catalyzed by the Britain's Compulsory Vaccination Act of 1853, which mandated the vaccination of all infants [1]. The controversial pertussis and hepatitis B virus (HBV) vaccines in conjunction with the apocryphal link between vaccination and autism not only re-catalyzed a groundswell of antivaccine activism but catapulted it into a phase of erudite opposition [2].Anti-vaccine groups are formed mostly by affluent "knowledge seekers" who claim the right to make "informed choices" about vaccination [2][3][4]. Today's vaccines largely represent a double-edged sword to vaccine resisters even though they are agnostic about what causes vaccines' side effects. Regardless of their creeds, the incipient anti-vaccine movements have been implicated in low vaccine coverages in conjunction with hazardous outbreaks of preventable diseases [5].The grand success of vaccination programs is undeniable, and no anti-vaccine groups in the modern era have advocated a divorce by forbidding vaccines altogether in the medical arsenal. The schism between vaccine supporters and resisters can be attributed to the scope of restricted use of vaccines. Vaccine supporters' zeitgeist is based on the belief that vaccines' risks are minuscule with their core health benefits in vanquishing diseases far eclipse their risks, whereas vaccine resisters fear the brunt of vaccination due to vaccines' incertitude and their arcane mechanisms of action. Overall, the bifurcated stances are not as mutually exclusive from an ethical perspective.Vaccine supporters often impugn vaccine resisters for avoiding vaccination against communicable diseases on the premise that individuals opting out of immunization may j...

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Safety of Measles-Containing Vaccines in 1-Year-Old Children

Cited by 39 publications

References 40 publications

An observational study of febrile seizures: the importance of viral infection and immunization

An observational study of febrile seizures: the importance of viral infection and immunization

Measles vaccine: Past, present, and future

Noninvasive vaccination as a casus belli to redeem vaccine value in the face of anti-vaccine movements

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