An observational study of febrile seizures: the importance of viral infection and immunization

Francis, Joshua; Richmond, Peter; Robins, Christine; Lindsay, Katie; Levy, Avram; Effler, Paul V.; Borland, Meredith L; Blyth, Christopher C

doi:10.1186/s12887-016-0740-5

Cited by 59 publications

(86 citation statements)

References 28 publications

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“…Coronavirus OC43 was found in 6.94% of patients in our study. Francis et al 26 also reported human coronavirus in 9% of children with FS and found that the OC43 type was the most commonly found strain, like our study.…”

Section: Discussionsupporting

confidence: 85%

“…Human bocavirus was first identified in 2005 and was previously detected in 9-10.4% of children with FS. 24,26 In our study, human bocavirus is mainly detected in children with complex FS; however, human bocavirus has been detected with other respiratory viruses and it is difficult to explain complex FS with only this pathogen. Further studies on the neurological consequences of bocavirus in young children are needed.…”

Section: Discussionmentioning

confidence: 61%

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Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)

Çarman

Çalık

Karal

et al. 2018

Human Vaccines & Immunotherapeutics

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Background: Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short-and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to detect etiological causes of FS for neurological perspective, further knowledge about the etiological causes of FS in children will support preventive measures and follow-up strategies. The aim of this study is to evaluate the percentage of respiratory viruses in children with FS. Methods: This prospective multicenter study, entitled "Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)" examined representative populations in eight different cities in Turkey between March 1, 2016 and April 1, 2017. Nasopharyngeal swabs were taken from all children at presentation. A respiratory multiplex array was performed to detect for influenza A and B; respiratory syncytial virus A and B; human parainfluenza virus 1-2-3 and 4; human coronavirus 229E and OC43; human rhinovirus; human enterovirus; human adenovirus; human bocavirus; human metapneumovirus. Results: During the study period, at least one virus was detected in 82.7% (144/174) of children with FS. The most frequently detected virus was adenovirus, followed by influenza A and influenza B. Detection of more than one virus was present in 58.3% of the children with FS, and the most common co-existence was the presence of adenovirus and influenza B. In children younger than 12 months, Coronavirus OC43 was the most common, while influenza A was most frequently observed in children older than 48 months (p < 0.05). Human bocavirus was common in children who experienced complex FS, while respiratory syncytial virus (RSV) A was more common in children who experienced simple FS. Influenza B virus was the most common virus identified in children who were experiencing their first incidence of FS (p < 0.05).Conclusions: This study indicates that respiratory viruses are important in the etiology of FS in children. The results show that antibiotics must be prescribed carefully in children with FS since the majority of cases are related to viral causes. Widespread use of the existing quadrivalent influenza vaccine might be useful for the prevention of FS related to the flu. Further vaccine candidates for potential respiratory pathogens, including RSV, might be helpful for the prevention of FS. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 61%

Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)

Çarman

Çalık

Karal

et al. 2018

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

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“…Pediatric infectious diseases are the most frequent environmental causes, of which viral infections are the most frequent entities in children. Recent studies have explored the connections between febrile seizures and respiratory and enteric viral infections [5,6].…”

Section: Introductionmentioning

confidence: 99%

Seasonal distribution of febrile seizure and the relationship with respiratory and enteric viruses in Korean children based on nationwide registry data

Han

Kim

Lee

et al. 2019

Seizure

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“…The peak incidence of FSs is in children aged 18 months, with the risk being markedly lower in those aged below 6 months or over 5 years 4) . The most common causes of FSs are viral infections; among them, influenza infection is associated with a higher incidence of FSs than any other respiratory virus 5) .…”

Section: Introductionmentioning

confidence: 99%

Impact of Influenza Infection on Febrile Seizures: Clinical Implications

Jang¹,

Lee²

2018

Child Neurol

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Purpose: Febrile seizures (FSs) are the most common type of seizure in the first 5 years of life and are frequently associated with viral infections. Influenza infection is associated with a variety of neurological conditions, including FSs. The purpose of this study was to evaluate the clinical implications of influenza infection in FSs. Methods: In total, 388 children with FS were divided into two groups: FS with influenza infection (n=75) and FSs without influenza infection (n=313). Their medical records, including seizure type, frequency, duration, and familial history of FSs or epilepsy, were retrospectively reviewed and the clinical characteristics of the two groups were compared. Results: In total, 75 of the 388 children (19.3%) had FSs associated with influenza infection; such children were significantly older than those with FSs without influenza infection (34.9± 22.3 months vs. 24.4± 14.2 months; P<0.001). The children who had more than two febrile seizures episodes were more prevalent in children with FS with influenza infection [40/75 (53.3%) vs. 92/313 (29.4%); P <0.01]. Children older than 60 months were more likely to have influenza infection compared to those aged less than 60 months [11/22 (50%) vs. 64/366 (17.5%); P=0.001]. Conclusion: Influenza infection may be associated with FSs in older children, and with recurrence of FSs. Its role in the development of afebrile seizures or subsequent epilepsy requires further investigation with long-term follow-up.

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An observational study of febrile seizures: the importance of viral infection and immunization

Cited by 59 publications

References 28 publications

Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)

Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)

Seasonal distribution of febrile seizure and the relationship with respiratory and enteric viruses in Korean children based on nationwide registry data

Impact of Influenza Infection on Febrile Seizures: Clinical Implications

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