Seasonal distribution of febrile seizure and the relationship with respiratory and enteric viruses in Korean children based on nationwide registry data

Han, Do Hoon; Kim, Su Yeong; Lee, Na Mi; Yi, Dae Yong; Yun, Sin Weon; Lim, In Seok; Chae, Soo Ahn

doi:10.1016/j.seizure.2019.10.008

Cited by 18 publications

(20 citation statements)

References 29 publications

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“…Viral infections are documented in up to 80% of febrile seizures (35), a figure that is comparable to the rate of viral infections in febrile children without seizures (36). The fall/winter seasonality in numerous studies (11,12), supports the association of febrile seizures with Upper Respiratory Tract Infections (URTIs) and their common causative viruses, including influenza viruses and respiratory syncytial virus (RSV) (3,34). Peaks of febrile seizure incidence in summer months correlate with increased gastroenteritis diagnoses in children in summer, including enteroviruses (34).…”

Section: The Role Of Viruses and Vaccinations Virusesmentioning

confidence: 82%

“…The fall/winter seasonality in numerous studies (11,12), supports the association of febrile seizures with Upper Respiratory Tract Infections (URTIs) and their common causative viruses, including influenza viruses and respiratory syncytial virus (RSV) (3,34). Peaks of febrile seizure incidence in summer months correlate with increased gastroenteritis diagnoses in children in summer, including enteroviruses (34). Nevertheless, many other viruses have been associated with febrile seizures (Table 3), but do not contribute to seasonal trends as clearly.…”

Section: The Role Of Viruses and Vaccinations Virusesmentioning

confidence: 86%

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A Review of Febrile Seizures: Recent Advances in Understanding of Febrile Seizure Pathophysiology and Commonly Implicated Viral Triggers

2022

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Febrile seizures are one of the commonest presentations in young children, with a 2–5% incidence in Western countries. Though they are generally benign, with rare long-term sequelae, there is much to be learned about their pathophysiology and risk factors. Febrile seizures are propagated by a variety of genetic and environmental factors, including viruses and vaccines. These factors must be taken into consideration by a clinician aiming to assess, diagnose and treat a child presenting with fevers and seizures, as well as to explain the sequelae of the febrile seizures to the concerned parents of the child. Our article provides an overview of this common childhood condition, outlining both the underlying mechanisms and the appropriate clinical approach to a child presenting with febrile seizures.

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Section: The Role Of Viruses and Vaccinations Virusesmentioning

confidence: 82%

Section: The Role Of Viruses and Vaccinations Virusesmentioning

confidence: 86%

A Review of Febrile Seizures: Recent Advances in Understanding of Febrile Seizure Pathophysiology and Commonly Implicated Viral Triggers

2022

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“…In Asian countries, Inf A virus is the most frequent etiological agent. 14 It was found that 87% were simple FSs, while 13% were complex FSs. Inf A was detected in 30% of complex FSs.…”

Section: Discussionmentioning

confidence: 99%

Influenza A as a Common Viral Cause of Complex Febrile Seizures

Esen

Seçilmiş

Doğan

et al. 2021

Journal of Pediatric Infectious Diseases

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Objective The most common childhood convulsive disorder happens to be febrile seizure (FS), which is an important health problem leading to economic burden and parental anxiety. Further investigation into the etiological causes of FS will guide us for appropriate measures during the follow-up period. The aim of study is to identify the percentage of viral and bacterial pathogens in the etiological causes of children with FS, and also if there is any difference between simple and complex FSs. Methods This prospective study randomly enrolled 100 pediatric patients with FS between January 2017 and July 2017. Nasopharyngeal swabs were obtained from all children at presentation. The respiratory panel was performed with a multiplex real-time polymerase chain reaction method to detect the 21 most common viruses. A complete blood count, absolute neutrophil count, absolute lymphocyte count, C-reactive protein, erythrocyte sedimentation rate, procalcitonin, blood culture, throat culture, urine analyses, urinary culture, and stool tests analysis were performed in all the patients. Results During the study period, at least one virus was detected in 87% of patients. Bacterial agents were detected in only 13% of patients. Coinfections of the viruses and bacterial pathogens were found in 24% of patients. The most frequently detected virus was influenza A (Inf A) (18%), followed by rhinovirus (12%). Coinfections of the viruses and bacterial pathogens, mixed viral infections, and Inf A were common in children who experienced complex FS. Inf A was detected in 16% of patients with simple FSs and 30% of patients with complex FSs and a significant difference between them (p < 0.01). Conclusion The results of this study showed that respiratory viral and bacterial pathogens are important in the etiology of FS in children. It is considered that complex FSs may be triggered by Inf A. The fact is viral pathogens are very common; therefore, antibiotics must be carefully prescribed. These results also draw attention to the use of the quadrivalent influenza vaccine in the prevention of FS related to the flu.

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“…Viral respiratory and gastrointestinal infections are dominant causes of febrile infections accompanied by FS. The viruses most strongly associated with FS include human herpes virus type 6, respiratory syncytial virus, influenza and parainfluenza viruses, human coronavirus, rotavirus, adenovirus, norovirus, and human bocavirus (8)(9)(10) . It is worth noting that children with diarrhoea without electrolyte disturbances or fever may develop benign convulsions with mild gastroenteritis (CwG) (11) .…”

Section: The Aetiological Factor Of Infectionmentioning

confidence: 99%

Aetiology of febrile seizures – a problem not fully understood

Grzywna-Rozenek¹,

Barć-Czarnecka²,

Machura³

2021

Pediatr Med Rodz

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Febrile seizures are seizures that occur during febrile illnesses in the absence of central nervous system infection or other identifiable aetiology in children who have never had any non-febrile seizures before. Although the condition is quite common, affecting 2–5% of children between 3 months and 5 years of age, the underlying pathomechanism is not fully explained. Immaturity of the nervous system, as well as environmental, genetic and immune factors are contemplated. Viruses are the main aetiological factor of febrile infections accompanied by seizures. The risk of febrile seizures after vaccination is low and may be associated with the child’s genetic predisposition. Deficiency of trace elements, including zinc and iron, may also promote seizures. The association between febrile seizures and vitamin D levels was reported in only few studies. It seems that genetic background plays an important role, at least in some cases. In recent years, particular attention has been paid to the possible involvement of immune factors, including pro- and anti-inflammatory cytokines. Previous studies on the aetiology of febrile seizures confirmed their multifactorial nature and indicated their heterogeneity within this group of patients. Further research may not only contribute to a better understanding of the mechanisms underlying the pathogenesis of febrile seizures, but also determine the direction of actions that may reduce the risk of their occurrence and/or recurrence.

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Seasonal distribution of febrile seizure and the relationship with respiratory and enteric viruses in Korean children based on nationwide registry data

Cited by 18 publications

References 29 publications

A Review of Febrile Seizures: Recent Advances in Understanding of Febrile Seizure Pathophysiology and Commonly Implicated Viral Triggers

A Review of Febrile Seizures: Recent Advances in Understanding of Febrile Seizure Pathophysiology and Commonly Implicated Viral Triggers

Influenza A as a Common Viral Cause of Complex Febrile Seizures

Aetiology of febrile seizures – a problem not fully understood

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