Safety of laparoscopy versus laparotomy in early-stage endometrial cancer: a randomised trial

Mourits, Marian J.E.; Bijen, Claudia B M; Arts, Henriëtte J.G.; Brugge, Henk G. ter; Sijde, Rob van der; Paulsen, Lasse; Wijma, Jacobus; Bongers, Marlies Y.; Post, Wendy J.; Zee, Ate Gj van der; Bock, Geertruida H. de

doi:10.1016/s1470-2045(10)70143-1

Cited by 284 publications

(226 citation statements)

References 32 publications

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“…However, previous randomized studies of TLH versus TAH in patients with endometrial cancer are limited, and more importantly, are not powered enough to give a precise estimate of the effects (Ju et al, 2009;Palomba et al, 2009). Two new randomized studies with large sample size were published to further assess the safety of TLH (Janda et al, 2010;Mourits et al, 2010). The outcomes from these two new randomized studies were also inconsistent from each other in terms of the safety of TLH (Janda et al, 2010;Mourits et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…The primary endpoints were the major complication rate and mortality rate, while the second end-points were total complication rate, postoperative complication rate and intra-operative complication rate. The major complications included injuries of bowel, bladder, ureter, vessel, nerves; thromboembolic events such as DVT (Deep Venous Thrombosis) or pulmonary embolism; haematoma requiring surgical intervention; hemorrhage requiring transfusion and/or surgical intervention; wound dehiscence requiring surgical intervention or re-admission; wound infections including vaginal vault abscess, requiring surgical intervention and/ or prolonged hospital stay and/or readmission and/or treatment; other major complications (Janda et al, 2010;Mourits et al, 2010).…”

Section: Data Extraction and Main Endpointsmentioning

confidence: 99%

“…Six studies were further excluded including one study for no available data (Nicklin et al, 2011) and 5 overlapping studies (Tozzi et al, 2005;Zullo et al, 2005;Bijen et al, 2009;. Finally, nine randomized controlled trials with a total of 1263 patients were included into this meta-analysis (Fram, 2002;Tozzi et al, 2005;Zorlu et al, 2005;Chen and Huang, 2007;Wang, 2008;Malzoni et al, 2009;Zullo et al, 2009;Janda et al, 2010;Mourits et al, 2010). The sample size in each trial was relatively small, ranging from 52 to 332 participants.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…The sample size in each trial was relatively small, ranging from 52 to 332 participants. The quality of randomized controlled trials was assessed by the Jadad's score, and 5 trials were high quality randomized controlled trials with scores no less than 3 points (Tozzi et al, 2005;Malzoni et al, 2009;Zullo et al, 2009;Janda et al, 2010;Mourits et al, 2010). Table 1 summarized the main results of this metaanalysis.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Total Laparoscopic Hysterectomy Versus Total Abdominal Hysterectomy for Endometrial Cancer: A Meta-analysis

Wang

Ren²,

Yang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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The standard surgery for early-stage endometrial cancer is total abdominal hysterectomy (TAH), while total laparoscopic hysterectomy (TLH) is less invasive and assumed to be associated with lower morbidity. This metaanalysis was performed to investigate the effects of TLH versus TAH in women with early-stage endometrial cancer. We searched the PubMed, EMBASE, CBM and Cochrane Review databases for randomized trials assessing the effects of TLH versus TAH in women with early-stage endometrial cancer. The relative risks (RR) with 95% confidence intervals (CIs) from each study were pooled using meta-analysis. In our study, 9 randomized trials with a total of 1,263 patients were included. Meta-analyses showed that TLH was associated with lower

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Section: Discussionmentioning

confidence: 99%

Section: Data Extraction and Main Endpointsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Total Laparoscopic Hysterectomy Versus Total Abdominal Hysterectomy for Endometrial Cancer: A Meta-analysis

Wang

Ren²,

Yang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Previous findings from the US Gynecologic Oncology Group (GOG) LAP2 trial suggest a lower incidence of surgical adverse events (AEs) in uterine cancer patients who received laparoscopic compared to open surgery (8). In contrast, the recently published Dutch TLH trial suggested a similar rate of surgical complications in laparoscopic and open surgery for early endometrial cancer and endometrial hyperplasia with atypia (9).…”

Section: Introductionmentioning

confidence: 99%

Risk factors to predict the incidence of surgical adverse events following open or laparoscopic surgery for apparent early stage endometrial cancer: Results from a randomised controlled trial

Kondalsamy‐Chennakesavan

Janda

Gebski

et al. 2012

European Journal of Cancer

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Aims: To identify risk factors for major Adverse Events (AEs) and to develop a nomogram to predict the probability of such AEs in individual patients who have surgery for apparent early stage endometrial cancer. Methods:We used data from 753 patients who were randomized to either total laparoscopic hysterectomy or total abdominal hysterectomy in the LACE trial. Serious adverse events that prolonged hospital stay or postoperative adverse events (using common terminology criteria 3+, CTCAE V3) were considered major AEs. We analyzed pre-surgical characteristics that were associated with the risk of developing major AEs by multivariate logistic regression.We identified a parsimonious model by backward stepwise logistic regression. The six most significant or clinically important variables were included in the nomogram to predict the risk of major AEs within 6 weeks of surgery and the nomogram was internally validated.Results: Overall, 132 (17.5%) patients had at least one major AE. An open surgical approach (laparotomy), higher Charlson's medical co-morbidities score, moderately differentiated tumours on curettings, higher baseline ECOG score, higher body mass index and low haemoglobin levels were associated with AE and were used in the nomogram. The bootstrap corrected concordance index of the nomogram was 0.63 and it showed good calibration. Conclusions:Six pre-surgical factors independently predicted the risk of major AEs. This research might form the basis to develop risk reduction strategies to minimize the risk of AEs among patients undergoing surgery for apparent early stage endometrial cancer. Clinical Trial Registration: NCT00096408

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Laparoscopic Hysterectomy for Endometrial Cancer

Wright

2017

JAMA

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Safety of laparoscopy versus laparotomy in early-stage endometrial cancer: a randomised trial

Cited by 284 publications

References 32 publications

Total Laparoscopic Hysterectomy Versus Total Abdominal Hysterectomy for Endometrial Cancer: A Meta-analysis

Total Laparoscopic Hysterectomy Versus Total Abdominal Hysterectomy for Endometrial Cancer: A Meta-analysis

Risk factors to predict the incidence of surgical adverse events following open or laparoscopic surgery for apparent early stage endometrial cancer: Results from a randomised controlled trial

Laparoscopic Hysterectomy for Endometrial Cancer

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