Safety of Islet Autotransplantation After Pancreatectomy for Adenocarcinoma

Renaud, François; Chetboun, Mikaël; Thévenet, Julien; Delalleau, Nathalie; Gmyr, Valéry; Hübert, Thomas; Bonner, Caroline; Messager, Mathieu; Leteurtre, Emmanuelle; Mariette, C.; Kerr–Conte, Julie; Piessen, Guillaume; Pattou, François

doi:10.1097/tp.0000000000002419

Cited by 8 publications

(9 citation statements)

References 16 publications

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“…Post-pancreatectomy diabetes is a classical complication encountered at 10 years in up to 16% of patients after pancreaticoduodenectomy and in 35% after distal pancreatectomy; therefore, physicians and patients should be aware of this risk before validating surgical indication and educate patients to avoid weight gain ( 146 , 147 ). Islet autotransplantation, now reimbursed through health insurance in France, could be an interesting option for limiting diabetes-associated morbidity; the procedure carries the risk of tumor occurrence in these genetically-determined diseases, although interesting results have been observed in pancreatic adenocarcinoma in an animal model ( 148 , 149 ).…”

Section: Digestive Neuroendocrine Neoplasms In Phakomatosesmentioning

confidence: 99%

Phakomatoses and Endocrine Gland Tumors: Noteworthy and (Not so) Rare Associations

Chevalier

Dupuis²,

Jannin

et al. 2021

Front. Endocrinol.

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Phakomatoses encompass a group of rare genetic diseases, such as von Hippel-Lindau syndrome (VHL), neurofibromatosis type 1 (NF1), tuberous sclerosis complex (TSC) and Cowden syndrome (CS). These disorders are due to molecular abnormalities on the RAS-PI3K-Akt-mTOR pathway for NF1, TSC and CS, and to hypoxia sensing for VHL. Phakomatoses share some phenotypic traits such as neurological, ophthalmological and cutaneous features. Patients with these diseases are also predisposed to developing multiple endocrine tissue tumors, e.g., pheochromocytomas/paragangliomas are frequent in VHL and NF1. All forms of phakomatoses except CS may be associated with digestive neuroendocrine tumors. More rarely, thyroid cancer and pituitary or parathyroid adenomas have been reported. These susceptibilities are noteworthy, because their occurrence rate, prognosis and management differ slightly from the sporadic forms. The aim of this review is to summarize current knowledge on endocrine glands tumors associated with VHL, NF1, TSC, and CS, especially neuroendocrine tumors and pheochromocytomas/paragangliomas. We particularly detail recent advances concerning prognosis and management, especially parenchyma-sparing surgery and medical targeted therapies such as mTOR, MEK and HIF-2 α inhibitors, which have shown truly encouraging results.

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Section: Digestive Neuroendocrine Neoplasms In Phakomatosesmentioning

confidence: 99%

Phakomatoses and Endocrine Gland Tumors: Noteworthy and (Not so) Rare Associations

Chevalier

Dupuis²,

Jannin

et al. 2021

Front. Endocrinol.

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“…Clinical contraindications for pancreatectomy with autologous islet transplantation in patients with pancreatic neoplasms are controversial. There are reports showing the successful use of this procedure in patients with pancreatic neoplasms (including IPMN, insulinoma, pancreatic and ampullary cancer, renal cell carcinoma (RCC) metastasis to pancreas) in the literature [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. Ris et al [ 34 ] described 25 patients undergoing extended pancreatectomy and islet autotransplantation for benign pancreatic tumors.…”

Section: Indications and Contraindications For Tpaitmentioning

confidence: 99%

Total Pancreatectomy with Autologous Islet Cell Transplantation—The Current Indications

Jabłońska

Mrowiec

2021

JCM

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Total pancreatectomy is a major complex surgical procedure involving removal of the whole pancreatic parenchyma and duodenum. It leads to lifelong pancreatic exocrine and endocrine insufficiency. The control of surgery-induced diabetes (type 3) requires insulin therapy. Total pancreatectomy with autologous islet transplantation (TPAIT) is performed in order to prevent postoperative diabetes and its serious complications. It is very important whether it is safe and beneficial for patients in terms of postoperative morbidity and mortality, and long-term results including quality of life. Small duct painful chronic pancreatitis (CP) is a primary indication for TPAIT, but currently the indications for this procedure have been extended. They also include hereditary/genetic pancreatitis (HGP), as well as less frequent indications such as benign/borderline pancreatic tumors (intraductal papillary neoplasms, neuroendocrine neoplasms) and “high-risk pancreatic stump”. The use of TPAIT in malignant pancreatic and peripancreatic neoplasms has been reported in the worldwide literature but currently is not a standard but rather a controversial management in these patients. In this review, history, technique, indications, and contraindications, as well as short-term and long-term results of TPAIT, including pediatric patients, are described.

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“…Опубликованы данные о применении ауто-ТОК после удаления поджелудочной железы по поводу доброкачественных опухолей, травмы, артериовенозных мальформаций. Возмож- ность ауто-ТОК при протоковой аденокарциноме и протоковых папиллярных муцинозных опухолях в настоящее время является спорной и требует дальнейшего изучения [43].…”

Section: аутотрансплантация островков после тотальной панкреатэктомииunclassified

“…Наиболее выраженное клиническое проявление ХП -постоянная или перемежающаяся боль в верхних отделах живота, которая наблюдается у 85-90% пациентов и приводит к значительному снижению качества жизни, вплоть до постоянного назначения наркотических препаратов [43,51,52].…”

Section: аутотрансплантация клеток островкового аппарата при хроничесunclassified

Transplantation technologies for treatment of carbohydrate metabolism disorders

Загайнов¹,

Meleshina

Korneva

et al. 2020

RJTAO

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The review includes results of retrospective and prospective clinical studies (foreign and national) and guidelines on the use of transplantation technologies for treatment of type 1 diabetes and pancreatogenic diabetes in chronic pancreatitis and pancreatic conditions. Modern data on prevalence of diabetes and modern insulin delivery methods are presented. Results of transplantation of pancreas and islets of Langerhans in primary insulin-dependent conditions are considered. Analysis of the technology for isolation and autotransplantation of islets after pancreatectomy in chronic pancreatitis and benign tumor diseases are given.

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Safety of Islet Autotransplantation After Pancreatectomy for Adenocarcinoma

Cited by 8 publications

References 16 publications

Phakomatoses and Endocrine Gland Tumors: Noteworthy and (Not so) Rare Associations

Phakomatoses and Endocrine Gland Tumors: Noteworthy and (Not so) Rare Associations

Total Pancreatectomy with Autologous Islet Cell Transplantation—The Current Indications

Transplantation technologies for treatment of carbohydrate metabolism disorders

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