Safety of Dietary Conjugated Linoleic Acid (CLA) in a 12-weeks Trial in Healthy Overweight Japanese Male Volunteers

Iwata, Toshio; Kamegai, Takeshi; Yamauchi-Sato, Yoshie; Ogawa, Akiko; Kasai, Michio; Aoyama, Toyohiko; Kondo, Kazuo

doi:10.5650/jos.56.517

Cited by 50 publications

(43 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our analysis showed that TAG level decreased nonsignificantly after intake of either CLA supplements or CLA-enriched foods, similar to previous studies on either enriched foods or CLA supplements. Some findings suggested that CLA had no significant effect on TAG concentration (11)(12)(13)(14)(15)(16)(17)(18)(19)21,22,(24)(25)(26)(27)(29)(30)(31)(32)(33)(34)36,40,(47)(48)(49)(50)(51)(52)(53)(55)(56)(57)(58)(59) .…”

Section: Discussionmentioning

confidence: 99%

Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis

Derakhshande-Rishehri

Mansourian

Kelishadi

et al. 2014

Public Health Nutr.

View full text Add to dashboard Cite

Objective: The present study aimed to review the association of conjugated linoleic acid (CLA) consumption in two forms, foods enriched in CLA and CLA supplements, with serum lipid profile in human studies. Design: Systematic review and meta-analysis. Setting: Search process was conducted in PubMed, Cochrane Library, Google Scholar, Scopus and Science Direct. Clinical trials that investigated the association of CLA intakes either in the form of supplements or enriched foods with lipid profile in healthy adults were included. All outcomes were recorded as continuous variables, and the effect size was measured by analysis of the mean and standard deviation before and after the intervention for case and control groups. Subjects: Healthy adult population. Results: CLA supplementation was associated with a significant decrease in LDL cholesterol (mean difference = − 0·218; 95 % CI − 0·358, − 0·077; P = 0·002), a nonsignificant decrease in HDL cholesterol (mean difference = − 0·051; 95 % CI − 0·188, 0·086; P = 0·468), a non-significant increase in total cholesterol (mean difference = 0·009; 95 % CI − 0·128, 0·146; P = 0·896) and a non-significant decrease in TAG (mean difference = − 0·065; 95 % CI − 0·20, 0·07; P = 0·344). Foods enriched with CLA were associated with significantly decreased LDL cholesterol (mean difference = − 0·231; 95 % CI − 0·438, − 0·024; P = 0·028), non-significantly increased HDL-C (mean difference = 0·075; 95 % CI − 0·121, 0·270; P = 0·455), non-significantly decreased total cholesterol (mean difference = − 0·158; 95 % CI − 0·349, 0·042; P = 0·124) and non-significantly decreased TAG (mean difference = − 0·078; 95 % CI − 0·274, 0·117; P = 0·433). Conclusions: According to our analysis, consumption of foods enriched with CLA or CLA supplements has favourable effects on LDL cholesterol levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis

Derakhshande-Rishehri

Mansourian

Kelishadi

et al. 2014

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…DHA possesses several metabolic and health promoting effects (Adkins & Kelley, 2010) and is present in a variety of natural and supplemented food products. The popularity of CLA as a weight-loss supplement comes from the marketing of its ability to reduce body fat mass without disclosure of its adverse effects, including those on NAFLD (Iwata et al, 2007;Ramos, Mascarenhas, Duarte, Vicente, & Casteleiro, 2009). The current study examined the capability of DHA to reverse existing CLA-induced (1) hepatic steatosis through the suppression of hepatic lipogenesis and activation of fatty acid oxidation, (2) hepatic inflammation and fibrosis by inhibiting tissue macrophage and HSC activation and serum alanine aminotransferase (ALT) activity, and (3) IR and low adiponectin levels by restoring AT mass.…”

Section: Introductionmentioning

confidence: 99%

Dietary docosahexaenoic acid reverses nonalcoholic steatohepatitis and fibrosis caused by conjugated linoleic acid supplementation in mice

Adkins

Fedor

Mackey

et al. 2016

Journal of Functional Foods

View full text Add to dashboard Cite

“…[16][17][18][19] However, most previous studies have focussed on industrial trans fatty acids [16][17][18][19] or CLA mixtures with a high content of trans-10, cis-12 CLA. [6][7][8] The trans-10, cis-12 isomer has been suggested to have more unfavourable effects on cardiovascular health than cis-9, trans-11 CLA. 2,20 Less was known about the effect of cis-9, trans-11 CLA.…”

Section: Discussionmentioning

confidence: 99%

“…Laso et al 7 studied the effects of a 12-week daily intervention with 3 g of a mixture of multiple CLA isomers or placebo in 60 overweight and obese individuals with a mean BP of 147/84 mm Hg and found no effect on BP. Additionally, Iwata et al 8 did a 12-week trial with a daily intake of 3.4 g CLA mixture in 60 healthy overweight Japanese male volunteers and also found no effect of CLA on BP. Finally, Sluijs et al 9 examined the effect of 6-month daily supplementation with 4 g CLA (2.5 g cis-9, trans-11 CLA and 0.6 g trans-10, cis-12 CLA) on aortic stiffness in 401 overweight and obese adults and found no effect on BP.…”

Section: Introductionmentioning

confidence: 99%

The effect of conjugated linoleic acid, a natural trans fat from milk and meat, on human blood pressure: results from a randomized crossover feeding study

et al. 2011

View full text Add to dashboard Cite

Cis-9, trans-11 conjugated linoleic acid (CLA) is a natural trans fatty acid that is largely restricted to ruminant fats and consumed in foods and supplements. Its role in blood pressure (BP) regulation is still unclear. We examined the effect of cis-9, trans-11 CLA on BP compared with oleic acid. A total of 61 healthy volunteers were sequentially fed each of 3 diets for 3 weeks, in random order, for a total of 9 weeks. The diets were identical except for 7% of energy (18.9 g in a diet of 10 MJ day -1 ) that was provided either by oleic acid, by industrial trans fatty acids or by cis-9, trans-11 CLA. We measured BP on two separate days at the end of each intervention period. At baseline, mean BP was 113.8 ± 14.4 mm Hg systolic and 66.3 ± 9.6 mm Hg diastolic. The effect of the CLA diet compared with the oleic acid diet was 0.11 mm Hg (95% confidence interval: À1.27, 1.49) systolic and À0.45 mm Hg (À1.63, 0.73) diastolic. After the industrial trans fatty acid diet, the effect was 1.13 mm Hg (À0.25, 2.51) systolic and À0.44 mm Hg (À1.62, 0.73) diastolic compared with the oleic acid diet. Our study suggests that short-term high intakes of cis-9,trans-11 CLA do not affect BP in healthy volunteers.

show abstract

Safety of Dietary Conjugated Linoleic Acid (CLA) in a 12-weeks Trial in Healthy Overweight Japanese Male Volunteers

Cited by 50 publications

References 29 publications

Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis

Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis

Dietary docosahexaenoic acid reverses nonalcoholic steatohepatitis and fibrosis caused by conjugated linoleic acid supplementation in mice

The effect of conjugated linoleic acid, a natural trans fat from milk and meat, on human blood pressure: results from a randomized crossover feeding study

Contact Info

Product

Resources

About