Safety, immunization coverage and determinants of a new kind of Hepatitis B vaccine firstly applied in Ningbo, China

Yang, Sijia; Ma, Xiao; Ni, Hongxia; Zhou, Shaoying; Hu, Danbiao; Shi, Honglian; Chen, Xiaoying; Dong, Hongjun; Xu, Guozhang

doi:10.1080/21645515.2015.1066946

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Although there had been a great improvement in infant Hep B coverage, this study showed that certain groups remained at high risk of not receiving a timely birth dose or full immunization. This was consistent with previous reports from other provinces of China [4,14,15,16,17], and was attributed to risk factors such as uneven economic development, rural areas, and ethnic minorities. Other reports from some developing countries attributed the delayed or incomplete Hep B vaccination to the poor practice of the vaccination service [18,19,20].…”

Section: Discussionsupporting

confidence: 93%

Hepatitis B Vaccination among 1999–2017 Birth Cohorts in Zhejiang Province: The Determinants Associated with Infant Coverage

Chen

Wang

et al. 2018

IJERPH

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This study aimed to investigate the coverage of hepatitis B vaccine (Hep B) and its completeness and timeliness for birth cohorts from 1999 to 2017 in Zhejiang province, East China. Demographic characteristics and vaccination records of Hep B of children born from January 1, 1999 to June 31, 2017 were extracted from the Zhejiang provincial immunization information system. The timeliness of the first dose of Hep B (Hep B1) was defined as the proportion of children who received the Hep B1 within 24 hours after birth among the target population. The completeness of Hep B was defined as the proportion of children who completed the three-dose series of Hep B before 7 years of age. The demographic characteristics of the target population were described. The coverage of each dose of Hep B, the timeliness of Hep B1, and the completeness of Hep B for each birth cohort were described. A logistic regression model was applied to detect the determinants of the timeliness of Hep B1 and the completeness of Hep B vaccination. The coverage of Hep B1 increased from 90.3% to 98.3%, the coverage of Hep B2 increased from 88.8% to 96.1%, and the coverage of Hep B3 increased from 86.4% to 94.2%. The timeliness of Hep B1 increased from 80.3% to 91.3%. The completeness of Hep B increased from 81.3% to 91.5%. The determinants of timeliness of Hep B1 included children’s delivery place, immigration status, maternal education level, and economic development level of resident area. The determinants of completeness of Hep B included children’s delivery place, immigration status, maternal education level, economic development level of resident area, maternal occupation, and frequency of vaccination service. Zhejiang province had achieved significant improvements in the timely administration of Hep B1 and the completeness of Hep B. To accelerate progress toward additional reductions in the transmission of hepatitis B virus, further efforts need to be focused on improving the timeliness of Hep B1 vaccination and reducing the drop-outs among disadvantaged children with the risk factors identified in this study.

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Section: Discussionsupporting

confidence: 93%

Hepatitis B Vaccination among 1999–2017 Birth Cohorts in Zhejiang Province: The Determinants Associated with Infant Coverage

Chen

Wang

et al. 2018

IJERPH

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“…Secondly, we confirmed that the vaccines were transported by cold-chain logistics and they were still under guarantee. Thirdly, all vaccines in this study were expressed in Hansenulapolymorpha, which has been routinely administered to infants at birth, and the Global Advisory Committee on Vaccine Safety has also confirmed its safety (Das et al, 2019;Yang et al, 2015). Finally, we came to the factor of weight.…”

Section: Discussionmentioning

confidence: 90%

Factors influencing survival of BALB/c mice and their effects on immune efficacy in an experiment of hepatitis B immunization

Wei¹,

Li²,

Lv³

et al. 2020

J. Vet. Med. Anim. Health

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There was an accidental death of BALB/c mice in the course of the experiment about hepatitis B immunization. The reasons of the mice breeding failure were analyzed in order to provide some experience for future animal preparation about hepatitis B immunization. Items of all mice including sex, age, dose of hepatitis B vaccine (HepBVac), dose of hepatitis B immunoglobulin (HBIG), immunization route, vaccination schedule and the acclimatization period were recorded before the first immunization. Among 334 mice included, the survival rates in different groups of initial ages were 45.9% in 3-week-old, 49.3% in 4-week-old, 51.9% in 5-week-old, 84.8% in 7-week-old and 96.6% in 8week-old; the survival rate in seven days acclimatization group was 96.6% and 53.3% in one day acclimatization group. Multivariate logistic regression analysis indicated that smaller ages (3 weeks, 4 weeks) and acclimatization for only one day were the independent risk factors affecting the survival of mice. Multivariate logistic regression analysis showed that injection with HBIG, lower dose of HepBVac and hypodermic injection were independent risk factors for low-and non-response to HepB Vac. It is suggested that the mice should be more than five-week-old and must have acclimated to the environment for one week before the experiment begins. The initial ages of the mice have no impact on their immune efficacy.

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Safety, immunization coverage and determinants of a new kind of Hepatitis B vaccine firstly applied in Ningbo, China

Cited by 2 publications

References 33 publications

Hepatitis B Vaccination among 1999–2017 Birth Cohorts in Zhejiang Province: The Determinants Associated with Infant Coverage

Hepatitis B Vaccination among 1999–2017 Birth Cohorts in Zhejiang Province: The Determinants Associated with Infant Coverage

Factors influencing survival of BALB/c mice and their effects on immune efficacy in an experiment of hepatitis B immunization

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