Hepatitis B Vaccination among 1999–2017 Birth Cohorts in Zhejiang Province: The Determinants Associated with Infant Coverage

Abstract

This study aimed to investigate the coverage of hepatitis B vaccine (Hep B) and its completeness and timeliness for birth cohorts from 1999 to 2017 in Zhejiang province, East China. Demographic characteristics and vaccination records of Hep B of children born from January 1, 1999 to June 31, 2017 were extracted from the Zhejiang provincial immunization information system. The timeliness of the first dose of Hep B (Hep B1) was defined as the proportion of children who received the Hep B1 within 24 hours after birth among the target population. The completeness of Hep B was defined as the proportion of children who completed the three-dose series of Hep B before 7 years of age. The demographic characteristics of the target population were described. The coverage of each dose of Hep B, the timeliness of Hep B1, and the completeness of Hep B for each birth cohort were described. A logistic regression model was applied to detect the determinants of the timeliness of Hep B1 and the completeness of Hep B vaccination. The coverage of Hep B1 increased from 90.3% to 98.3%, the coverage of Hep B2 increased from 88.8% to 96.1%, and the coverage of Hep B3 increased from 86.4% to 94.2%. The timeliness of Hep B1 increased from 80.3% to 91.3%. The completeness of Hep B increased from 81.3% to 91.5%. The determinants of timeliness of Hep B1 included children’s delivery place, immigration status, maternal education level, and economic development level of resident area. The determinants of completeness of Hep B included children’s delivery place, immigration status, maternal education level, economic development level of resident area, maternal occupation, and frequency of vaccination service. Zhejiang province had achieved significant improvements in the timely administration of Hep B1 and the completeness of Hep B. To accelerate progress toward additional reductions in the transmission of hepatitis B virus, further efforts need to be focused on improving the timeliness of Hep B1 vaccination and reducing the drop-outs among disadvantaged children with the risk factors identified in this study.

Distribution, toxicity load, and risk assessment of dissolved metal in surface and overlying water at the Xiangjiang River in southern China

“…Therefore, among the heavy metals in the Xiangjiang River, Cd and As are the major sources of carcinogenic risk. Previous studies have also found carcinogenic risks from exposure to arsenic and cadmium in surface water 49 , 50 . It has been shown that As in drinking water can cause liver cancer, lung cancer, hypertension, neuropathy, etc., and Cd can damage lung and trigger DNA mutation 24 , 51 .…”

Use of controlled temperature chain and compact prefilled auto-disable devices to reach 2030 hepatitis B birth dose vaccination targets in LMICs: a modelling and cost-optimisation study

“…8 Within each setting, overall baseline birth dose coverage came from reported estimates but was distributed among facility and community births at a ratio of 2:1, with the relative likelihood of vaccination doubled and delivery more prompt in facilities than with community births (appendix p 4). 28 Annual age-specific, all-cause mortality probabilities were taken from the UN Population Division, reflective of 2015-20. 36 Populationweighted GBD region averages can be seen in the appendix (pp 3-4).…”

Host Genetic Determinants of Hepatitis B Virus Infection

“…Hepatitis B vaccines are widely used and effective for the prevention of new HBV infections. However, the overall success rate of hepatitis B vaccination is about 90% (Bruce et al, 2016; Hu et al, 2018). The outcome of HBV infection can vary dramatically, depending on both host and viral factors.…”