Safety Evaluation of Salinomycin in Broiler Chickens Reared in Floor Pens

Abstract

Salinomycin (Coxistac), a new broad spectrum anticoccidial, was tested in broilers reared in floor pens for safety at 50, 60, 80, 100, and 160 ppm fed continuously from 1 to 56 days of age. Four trials were conducted. Comparisons were made to unmedicated controls and in three trials to monensin to monensin at 80, 100, and 121 ppm. The weight gains at 50 and 60 ppm of salinomycin and 80 and 100 ppm of monensin were statistically comparable and equivalent to or better than controls. The weight gain at 80 ppm of salinomycin was slightly below controls but comparable to 121 ppm monensin. Levels of 100 and 160 ppm of salinomycin depressed weight gain. Feed conversion for all treatments except 160 ppm salinomycin were comparable.

Concentrations of salinomycin in eggs and tissues of laying chickens fed medicated feed for 14 days followed by withdrawal for 3 days†

“…69). SAL impairs the performance of broiler chickens at concentrations higher than 100 ugg" 1 in total feed (Migaki and898 M. H. Akhtar et al Babcock 1979, Shehata et al 1990) and is highly toxic to turkeys (Yong 1990). SAL is not recommended for use in layers, however, there may be situations where inadvertent misuse could occur.…”

Ionophore Toxicity in Animals: A Review of Clinical and Molecular Aspects

“…K + efflux into the cytoplasm decreases the pH. Reduction of pH increases intracellular Ca 2+ levels and injures mitochondria via mitochondria membrane interruption and production of reactive oxygen species (ROS) [ 39 ].…”

“…In broiler chickens, the salinomycin non-toxic dose was determined to be 60 ppm [ 39 ]. Compared to chickens, turkeys are more sensitive to the intoxication of salinomycin [ 40 ].…”

Salinomycin as a potent anticancer stem cell agent: State of the art and future directions

“…In general, salinomycin's actions can be very dose‐dependent, species‐dependent, and cell type‐dependent. 26 , 121 Salinomycin is already an approved drug by the United States Food and Drug Administration (FDA) for use in animal feeds. 122 At a normal feeding dosage, salinomycin does not cause noticeable abnormalities in animals.…”