Safety evaluation and antiobesogenic effect of Sargassum liebmannii J. Agardh (Fucales: Phaeophyceae) in rodents

Tapia-Martínez, Jorge; Hernández-Cruz, Karina; Franco-Colín, Margarita; Mateo‐Cid, Luz Elena; Mendoza-González, Catalina; Blas-Valdivia, Vanessa; Cano-Europa, Edgar

doi:10.1007/s10811-019-1752-y

Cited by 6 publications

(7 citation statements)

References 38 publications

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“…The acute toxicity study was determined in mice as LD50 > 10 g kg -1 , which agrees with other toxicity studies of brown algae such as Sargassum liebmannii and the fucoidan from Saccharina japonica (Kumar et al 2009, Tapia-Martinez et al 2019. According to the value of LD50 in the scale proposed by Loomis & Hayes (1996), M. pyrifera can be classified as non-toxic.…”

Section: Discussionsupporting

confidence: 83%

“…The experiments were design as previously reported (Tapia-Martinez et al 2019). The LD50 acute toxicity test was based in accordance with the method provided by the Organization for Economic Cooperation and Development (OECD 2008) and Lorke method (Lorke 1983).…”

Section: Rodents Experimentsmentioning

confidence: 99%

“…On the other hand, toxicological studies are very important to consider that the consumption of algae is safe for humans, this because, in the cell walls, kelps contain structural polysaccharides such as alginates, which can act as binding sites for the accumulation of toxic substances that are resuspended in marine currents, such as heavy metals. This situation is important since if consumed, it can cause alterations in oxidative stress and in the REDOX environment of the organism, causing functional and structural changes in tissues (Tapia-Martinez et al 2019). Although M. pyrifera is widely consumed, there are no toxicological studies to ensure its consumption as an additive in animal diets or for direct human consumption.…”

Section: Ld50 Acute Toxicity Testmentioning

confidence: 99%

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Toxicological and therapeutic evaluation of the algae <i>Macrocystis pyrifera</i> (Phaeophyceae) in rodents

Tapia-Martínez¹,

Cano-Europa²,

Casas-Valdéz³

et al. 2020

RBMO

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Macrocystis pyrifera is a giant brown seaweed with high nutritional content, used as a dietary supplement in some farm animals. It contains fucoidan which has a pharmacological effect on lipids and glucose metabolism. Some brown seaweeds can bioaccumulate toxic elements in their cell wall, representing a problem if toxicity tests that guarantee the safety of their consumption are not done. M. pyrifera, does not present toxicological studies that guarantee its safety. This work aimed to perform the acute and subchronic toxicological evaluation of M. pyrifera in rodents as well as to determine its possible therapeutic effect. Fronds of M. pyrifera were collected in Baja California Sur, Mexico, for drying and obtaining algae flour. The acute toxicity test LD50 was performed in C57BL / 6 male mice (25 ± 3 g) for 7 days, finding an LD50 greater than 10 g kg-1. Subchronic toxicity was determined for 121 days in adult male Sprague Dawley rats (98 ± 2 g), during which the experimental animals showed no signs of toxicity, or changes in the hematological, biochemical and histopathological parameters of the organs. The reactive oxygen species, lipid peroxidation or glutathione ratio were not different from the control group. A therapeutic effect on the regulation of body weight and a hypolipidemic effect (triacylglycerides: 82.27 ± 5.55 mg dl-1, cholesterol: 98.61 ± 6.48 mg dl-1) were found. It is concluded that, under the conditions in which this study was developed, the consumption of M. pyrifera as a functional ingredient is safe.

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Section: Discussionsupporting

confidence: 83%

Section: Rodents Experimentsmentioning

confidence: 99%

Section: Ld50 Acute Toxicity Testmentioning

confidence: 99%

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Toxicological and therapeutic evaluation of the algae <i>Macrocystis pyrifera</i> (Phaeophyceae) in rodents

Tapia-Martínez¹,

Cano-Europa²,

Casas-Valdéz³

et al. 2020

RBMO

Self Cite

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show abstract

“…Fisheries and Aquatic Sciences genera, such as Ecklonia, Agarum, Sargassum, and Turbinaria, and contains potential bioactive substances, because it produces secondary metabolites, including alginic acid, fucoidan, polyphenol, alkaloids, and fatty acids (Tapia-Martinez et al, 2019). MBS extracted from Phaeophycea show antibacterial, anticoagulant, antithrombotic, antitumor, antiviral, and antiinflammatory properties (Achmad et al, 2020b;Leal et al, 2018;Ren et al, 2019).…”

Section: Trend Analysis On Extraction Source Of Marine Bioactive Subs...mentioning

confidence: 99%

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

Lee¹,

Kwon²,

Jung³

2023

Fish Aquat Sci

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Marine bioactive substances (MBS), such as phlorotannins, collagens, peptides, sterols, and polysaccharides, are increasing attention as therapeutic agents for several diseases due to their pharmacological effects. Previous studies have demonstrated the biological activities of MBS including antibacterial, anticoagulant, antidiabetic, antimicrobial, anti-inflammatory activities. Among numerous human diseases, periodontitis is one of the high-prevalence inflammatory diseases in the world. To treat periodontitis, several surgeries (bone grafting, flap surgery, and soft tissue graft) are usually used. However, the surgery for patients with chronic periodontitis induces several side effects, including additional inflammatory responses at the operated site, chronic wound healing, and secondary surgery. Therefore, this review assessed the most recent trends in MBS using Google Scholar, PubMed, and Web of Science search engines to develop marine-derived therapeutic agents for periodontitis. Further, we summarized the current applications and therapeutic potential of MBS to serve as a reference for developing novel technologies applied to MBS against periodontitis treatment.

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“…It has been further shown that PPAR gamma and CCAAT/enhancer binding protein (C/EBP) alpha mRNA levels were downregulated in WAT, while the expression of thermogenic proteins in brown adipose tissue were upregulated [24]. Others have shown that Sargassum liebmannii reduced energy intake, improved insulin sensitivity and as a result reduced adipose tissue content in rats [25]. Although the specific mechanism of their lipid reducing effect is yet unknown, these preliminary studies have laid a solid foundation for future research on specific active molecules and their underlying mechanisms of action.…”

Section: Algal Marine Productsmentioning

confidence: 99%

Advances in the Study of Marine Products with Lipid-Lowering Properties

et al. 2020

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With twice the number of cancer’s deaths, cardiovascular diseases have become the leading cause of death worldwide. Atherosclerosis, in particular, is a progressive, chronic inflammatory cardiovascular disease caused by persistent damage to blood vessels due to elevated cholesterol levels and hyperlipidemia. This condition is characterized by an increase in serum cholesterol, triglycerides, and low-density lipoprotein, and a decrease in high-density lipoprotein. Although existing therapies with hypolipidemic effects can improve the living standards of patients with cardiovascular diseases, the drugs currently used in clinical practice have certain side effects, which insists on the need for the development of new types of drugs with lipid-lowering effects. Some marine-derived substances have proven hypolipidemic activities with fewer side effects and stand as a good alternative for drug development. Recently, there have been thousands of studies on substances with lipid-lowering properties of marine origin, and some are already implemented in clinical practice. Here, we summarize the active components of marine-derived products having a hypolipidemic effect. These active constituents according to their source are divided into algal, animal, plant and microbial and contribute to the development and utilization of marine medicinal products with hypolipidemic effects.

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Safety evaluation and antiobesogenic effect of Sargassum liebmannii J. Agardh (Fucales: Phaeophyceae) in rodents

Cited by 6 publications

References 38 publications

Toxicological and therapeutic evaluation of the algae <i>Macrocystis pyrifera</i> (Phaeophyceae) in rodents

Toxicological and therapeutic evaluation of the algae <i>Macrocystis pyrifera</i> (Phaeophyceae) in rodents

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

Advances in the Study of Marine Products with Lipid-Lowering Properties

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