Safety, Effectiveness, and Subjective Experience with Topical Bimatoprost 0.03% for Eyelash Growth

Abstract

Bimatoprost was found safe for eyelid application and was associated with enhanced eyelash growth. All subjects noticed favorable changes in the appearance of their eyelashes.

Eyelash growth in subjects treated with bimatoprost: A multicenter, randomized, double-masked, vehicle-controlled, parallel-group study

“…6,9 Recently, the effects of bimatoprost 0.03% on eyelash growth when applied topically to the skin of the eyelid margins were evaluated in an open-label study that found bimatoprost 0.03% to be safe and associated with longer, thicker, and darker eyelashes. 10 The current study aimed to evaluate the safety and efficacy of once-daily administration of bimatoprost 0.03% or vehicle to the upper eyelid margins.…”

Long-Term Utility and Durability of the Therapeutic Effects of Bimatoprost 0.03% for Eyelash Augmentation in Healthy Asian Subjects

“…This outcome was confirmed in case studies and in a formal proof-of-concept study, with bimatoprost 0.03% ophthalmic solution applied daily to the upper eyelashes [5,6,7]. In the pivotal study conducted in the United States in 278 healthy subjects, a statistically significant improvement from baseline in eyelash prominence was demonstrated in the bimatoprost 0.03% group versus the vehicle control group, based on the validated physician's Global Eyelash Assessment (GEA) scale [7,8]. Statistically significant increases in eyelash length, thickness and darkness were also observed in the bimatoprost 0.03% group versus the control [8].…”

“…During the pre-registration studies of bimatoprost 0.03% in glaucoma, eyelash growth was frequently documented as an adverse event (AE) [2,3,4]. This outcome was confirmed in case studies and in a formal proof-of-concept study, with bimatoprost 0.03% ophthalmic solution applied daily to the upper eyelashes [5,6,7]. In the pivotal study conducted in the United States in 278 healthy subjects, a statistically significant improvement from baseline in eyelash prominence was demonstrated in the bimatoprost 0.03% group versus the vehicle control group, based on the validated physician's Global Eyelash Assessment (GEA) scale [7,8].…”

“…Improvement in overall eyelash prominence was also evaluated by the physician investigators using the GEA scale [7,8]. Briefly, this is a 4-grade ordinal scale: 1 = worst possible/none to minimal eyelash prominence; 2 = moderate eyelash prominence; 3 = marked eyelash prominence; 4 = very marked/best possible eyelash prominence.…”

Adjunctive Skin Care of the Brow and Periorbital Region

“…79 Its safety, efficacy, and tolerability are well documented. 80,81 The successful use of bimatoprost for eyelash enhancement has led to its off-label use to treat eyebrows and, in the experience of the authors, is something often initiated by the patient with successful results. Although not FDA-approved for this purpose, a recent publication seems to support the use of bimatoprost ophthalmic solution 0.03% for eyebrow growth.…”