Safety and usefulness of cryopreservation of ovarian tissue to preserve fertility: a 12-year retrospective analysis

Imbert, R; Moffa, Federica; Tsépélidis, Sophie; Simon, Philippe; Delbaere, Anne; Devreker, Fabienne; Dechene, Julie; Ferster, Alina; Veys, Isabelle; Fastrez, Maxime; Englert, Yvon; Demeestere, Isabelle

doi:10.1093/humrep/deu158

Cited by 138 publications

(112 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The option of ovarian tissue cryopreservation for fertility preservation has to be considered very carefully and a risk and benefit analysis for each individual patient should be made [19]. Future transplantation of ovarian tissue is currently not possible for a number of cancer types due to inferred high risks of reintroducing malignant cells (review Rosendahl [20]).…”

Section: Discussionmentioning

confidence: 99%

In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe

Segers¹,

Mateizel²,

Moer³

et al. 2015

J Assist Reprod Genet

128

105

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe

Segers¹,

Mateizel²,

Moer³

et al. 2015

J Assist Reprod Genet

128

105

View full text Add to dashboard Cite

show abstract

“…In this study, 40% of the women for whom ovarian tissue was cryopreserved and had active pregnancy wish became pregnant spontaneously despite having had an entire or partial ovary removed. Another single-center study of 114 patients in Belgium reported similar data, with 30% of them being conceived spontaneously [24]. Better selection of candidates for cryopreservation should be based on their ability and willingness to have cryopreserved ovarian tissue replaced.…”

Section: Discussionmentioning

confidence: 72%

A Real-Life Analysis of Reproductive Outcome after Fertility Preservation in Female Cancer Patients

Hulsbosch¹,

Koskas²,

Tomassetti³

et al. 2017

Gynecol Obstet Invest

View full text Add to dashboard Cite

Background: Fertility preservation before or during cancer treatment in young women has become an important health issue because of delayed motherhood and improved survival rates. This study evaluates the necessity and the efficacy of fertility preservation, with a focus on actual pregnancy wish and outcome after fertility preservation and cancer treatment. Patients and Methods: All consecutive patients who received fertility preservation in 2 university referral centers before or during cancer treatment were included. After a minimal follow-up of 3 years, pregnancy wish, pregnancy attempts and fertility outcome were assessed during a dedicated consultation or during a telephone interview. Results: A total of 159 patients received fertility preservation including hormonal protection with gonadotropin-releasing hormone agonist (n = 93, 58.5%), ovarian tissue cryopreservation (n = 44, 27.7%), and combined hormonal protection and ovarian tissue cryopreservation (n = 22, 13.8%). Among the 91 (57.2%) patients in remission after a mean follow-up of 61.5 months, 29 (31.9%) women actively attempted pregnancy. Patients who had received ovarian cryopreservation were more likely to attempt pregnancy (18/66) than those who only received hormonal protection (11/93, p = 0.02). Out of the 29 women who attempted pregnancy, 16 (55.2%) became pregnant, and most of them conceived spontaneously (87.5%, 14/16). Out of the 13 women who did not become pregnant, 1 patient adopted a child and 12 patients still wanted to become pregnant, including 1 patient who underwent a transplantation of her cryopreserved ovarian tissue without success. Conclusion: In one of the first studies reporting real-life experience in centers for fertility preservation, we found that, within 5 years following the end of cancer treatment, only one third of patients in remission attempted to become pregnant, with a pregnancy rate of 55%, mostly after spontaneous conception.

show abstract

“…To date, more than 40 live births after using this technique have been reported worldwide. However, the pregnancy rate after the autografting of frozen-thawed ovarian tissue is approximately 30 % [1,2]. The absence of vascular anastomoses between host and grafted tissues is responsible for post-transplantation ischemic injuries that jeopardize long-term fecundity.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of the anti-apoptotic drug Z-VAD-FMK on human ovarian granulosa cell lines for further use in ovarian tissue transplantation

Fransolet

Henry

Labied

et al. 2015

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

Safety and usefulness of cryopreservation of ovarian tissue to preserve fertility: a 12-year retrospective analysis

Abstract: This study was supported by the Télévie, FNRS-FRSM and Fondation Belge contre le cancer. There are no competing interests to report.

Cited by 138 publications

References 37 publications

In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe

In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe

A Real-Life Analysis of Reproductive Outcome after Fertility Preservation in Female Cancer Patients

In vitro evaluation of the anti-apoptotic drug Z-VAD-FMK on human ovarian granulosa cell lines for further use in ovarian tissue transplantation

Contact Info

Product

Resources

About