Safety and tumor tissue accumulation of pegylated graphene oxide nanosheets for co-delivery of anticancer drug and photosensitizer

Miao, Wenjun; Shim, Gayong; Lee, Sangbin; Lee, Soondong; Choe, Yearn Seong; Oh, Yu‐Kyoung

doi:10.1016/j.biomaterials.2013.01.010

Cited by 219 publications

(144 citation statements)

References 38 publications

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“…A similar finding was also observed for other types of cancer cells such as HeLa cancer cells, 78 where cell viability of 90% was observed for GO at 40 μg/mL. Miao et al 79 also observed about 87% cell viability of GO towards SCC7 cells.…”

supporting

confidence: 77%

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

Muthoosamy

Bai

Abubakar

et al. 2015

IJN

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Purpose A simple, one-pot strategy was used to synthesize reduced graphene oxide (RGO) nanosheets by utilizing an easily available over-the-counter medicinal and edible mushroom, Ganoderma lucidum . Methods The mushroom was boiled in hot water to liberate the polysaccharides, the extract of which was then used directly for the reduction of graphene oxide. The abundance of polysaccharides present in the mushroom serves as a good reducing agent. The proposed strategy evades the use of harmful and expensive chemicals and avoids the typical tedious reaction methods. Results More importantly, the mushroom extract can be easily separated from the product without generating any residual byproducts and can be reused at least three times with good conversion efficiency (75%). It was readily dispersible in water without the need of ultrasonication or any surfactants; whereas 5 minutes of ultrasonication with various solvents produced RGO which was stable for the tested period of 1 year. Based on electrochemical measurements, the followed method did not jeopardize RGO’s electrical conductivity. Moreover, the obtained RGO was highly biocompatible to not only colon (HT-29) and brain (U87MG) cancer cells, but was also viable towards normal cells (MRC-5). Conclusion Besides being eco-friendly, this mushroom based approach is easily scalable and demonstrates remarkable RGO stability and biocompatibility, even without any form of functionalization.

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supporting

confidence: 77%

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

Muthoosamy

Bai

Abubakar

et al. 2015

IJN

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“…PEG-grafted GO (pGO) nanosheets were developed for co-delivery of the anticancer drug doxorubicin (Dox) and the photosensitizer chlorin e6 (Ce6) by physicochemical adsorption, resulting in combined chemophotodynamic therapy. 20 The size of Ce6-and Dox-loaded pGO nanophysisorplexes (Ce6/Dox/pGO) was controlled at 148.0±18.0 nm. In vitro and in vivo studies indicated significantly higher photodynamic anticancer effects upon co-delivery of Dox and Ce6 by pGO, compared to the delivery of Ce6 or Dox alone by the pGO nanosheets.…”

mentioning

confidence: 99%

Graphene-based nanovehicles for photodynamic medical therapy

Li¹,

Dong²,

Li³

et al. 2015

IJN

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Graphene and its derivatives such as graphene oxide (GO) have been widely explored as promising drug delivery vehicles for improved cancer treatment. In this review, we focus on their applications in photodynamic therapy. The large specific surface area of GO facilitates efficient loading of the photosensitizers and biological molecules via various surface functional groups. By incorporation of targeting ligands or activatable agents responsive to specific biological stimulations, smart nanovehicles are established, enabling tumor-triggering release or tumor-selective accumulation of photosensitizer for effective therapy with minimum side effects. Graphene-based nanosystems have been shown to improve the stability, bioavailability, and photodynamic efficiency of organic photosensitizer molecules. They have also been shown to behave as electron sinks for enhanced visible-light photodynamic activities. Owing to its intrinsic near infrared absorption properties, GO can be designed to combine both photodynamic and photothermal hyperthermia for optimum therapeutic efficiency. Critical issues and future aspects of photodynamic therapy research are addressed in this review.

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“…Miao et al reported the use of PEGylated GO nanosheets for co-delivery of doxorubicin and Ce6 to cancer cells both in vitro and in vivo. 109 Both in vitro and in vivo studies showed enhanced therapeutic e®ect of the combined therapy in comparison to GO mediated chemotherapy and PDT alone. In a similar study, Zhou et al showed a synergistic chemo-PDT of cancer by using GO sheets co-loaded with the anti-cancer drug 7-ethyl-10-hydroxycamptothecin (SN-38) and photosensitizer HA and observed signi¯cantly enhanced therapeutic e®ects of the combined therapy.…”

Section: Combined Chemo-photodynamic Therapymentioning

confidence: 99%

Graphene-Based Nanomaterials for Theranostic Applications

Roy

Jaiswal

2017

Rep. Adv. Phys. Sci.

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Graphene and graphene-based nanomaterials such as graphene oxide (GO), reduced graphene oxide (rGO) and graphene quantum dots (GQDs) have gained a lot of attention from diverse scienti¯c¯elds for applications in sensing, catalysis, nanoelectronics, material engineering, energy storage and biomedicine due to its unique structural, optical, electrical and mechanical properties. Graphene-based nanomaterials emerge as a novel class of nanomedicine for cancer therapy for several reasons. Firstly, its structural properties like high surface area and aromaticity enables easy loading of hydrophobic drugs. Secondly, presence of oxygen containing functional groups improve its physiological stability and also act as site for biofunctionalization. Thirdly, its optical absorption in the NIR region enable them to act as photoagents for photothermal and photodynamic therapies of cancer, both in vitro and in vivo. Finally, its intrinsic°u orescence property helps in bioimaging of cancer cells. Overall, graphene-based nanomaterials can act as agents for developing multifunctional theranostic platforms for carrying out more e±cient detection and treatment of cancers. This review provides a detailed summary of the di®erent applications of graphene-based nanomaterials in drug delivery, nucleic acid delivery, phototherapy, bioimaging and theranostics.

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Safety and tumor tissue accumulation of pegylated graphene oxide nanosheets for co-delivery of anticancer drug and photosensitizer

Cited by 219 publications

References 38 publications

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

Graphene-based nanovehicles for photodynamic medical therapy

Graphene-Based Nanomaterials for Theranostic Applications

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