2018
DOI: 10.18632/aging.101354
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Abstract: Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models. The present translational study aimed to determine safety and tolerability of a wheat germ extract containing enhanced spermidine concentrations. In a preclinical toxicity study, supplementation of spermidine using this extract did not result in morbidities or changes in behavior in BALBc/Rj mice during the 28-days repeated-dose tolerance study. Post morte… Show more

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Cited by 79 publications
(41 citation statements)
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References 38 publications
(41 reference statements)
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“…Spermidine has recently been administered to humans in a small experimental trial with a beneficial effect on cognitive function without adverse effects 36,37 . It remains to be shown whether at such low doses it has an effect on autophagy.…”
Section: Discussionmentioning
confidence: 99%
“…Spermidine has recently been administered to humans in a small experimental trial with a beneficial effect on cognitive function without adverse effects 36,37 . It remains to be shown whether at such low doses it has an effect on autophagy.…”
Section: Discussionmentioning
confidence: 99%
“…N1-acetylspermine (N1-AcSpm) and N1-acetylspermidine (N1-AcSpd) are synthesized by the transfer of an acetyl group from acetyl-coenzyme A to the N1-position of either Spd or Spm, respectively, which is catalyzed by Spd/Spm acetyltransferase 1 or 2 (SAT1/2). [9][10][11] Levels of Spd and Spm are lower in 60-to 80-year-olds than in 31to 56-year-olds. 7 Spd and Spm have been shown to increase the lifespan of different species and improve neural functions via enhancement of autophagy in Caenorhabditis elegans, Drosophila, and mice.…”
mentioning
confidence: 89%
“…2,6 Human whole blood concentrations of Spd and Spm are kept strictly within the 4 to 40μM range. [9][10][11] Levels of Spd and Spm are lower in 60-to 80-year-olds than in 31to 56-year-olds. 12 In the rat cerebral cortex and human basal ganglia, the levels of Spd and Spm decrease with age.…”
mentioning
confidence: 89%
“…In both cases, SARS-CoV-2 growth was reduced by 70%, suggesting that both compounds exhibit long-lasting antiviral effects, and supporting further investigation into prophylactic use of these compounds. For clinical use, half-maximal inhibitory concentration (IC50) of compounds should be in a non-toxic range and reach adequate plasma levels ( 35 ). The IC50 was 149 μM (R 2 = 0.71) for spermidine, 0.09 μM (R 2 = 0.95) for MK-2206, and 0.17 μM (R 2 = 0.63) for niclosamide, based on plaque-forming infectious units ( Figure 4c) .…”
Section: Fig1mentioning
confidence: 99%