Safety and Tolerability of Sedation-Free Flexible Cystoscopy for Intradetrusor Botulinum Toxin-A Injection

Cohen, Brian L.; Rivera, Rolando; Barboglio, Paholo; Gousse, Angelo E.

doi:10.1016/j.juro.2006.10.050

Cited by 47 publications

(30 citation statements)

References 17 publications

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“…In addition, for the proximal smoothmuscle sphincter, the use of oral alpha-blocker medication can be used for inhibition [27]. The urinary incontinence from an overactive bladder could be managed by oral anticholinergic medication or low doses of botulinum toxin into the bladder wall [1,[28][29]. Although the peak bladder pressure induced with stimulation could be reduced by these treatments, other overactive bladder conditions are treated with these interventions without producing urinary retention.…”

Section: Discussionmentioning

confidence: 99%

Effective methods of pelvic plexus nerve and bladder stimulation in anesthetized animal model

Bresler

Walter²,

Jahoda³

et al. 2008

JRRD

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Abstract-Urinary retention is a serious urological problem associated with spinal cord injuries (SCIs) and other pelvic disorders. Effective methods of pelvic nerve stimulation were investigated for this problem. Following anesthesia in five dogs, the bladder was surgically exposed. Bladder and anal sphincter pressures were recorded. Testing was first conducted with probe electrodes. Barb electrodes were then implanted with a needle near the pelvic plexus nerves and the bladder wall. We tested different electrode arrangements and stimulating parameters to induce bladder contractions without skeletal muscle stimulation. The pelvic plexus nerves near the bladder were identified, and the barb electrodes were effectively implanted. Stimulation with bipolar and bilateral electrodes induced pressures over 30 cmH 2 O without skeletal muscle activation. Common stimulation parameters were 40 pps, 400 microseconds pulse duration, and 15 to 25 mA stimulating current applied for 3 s. Effective electrode implantation methods were shown. Also identified were electrode arrangements and stimulating parameters that induced strong bladder contractions without skeletal muscle activation. However, voiding studies were not conducted. Further studies with barb electrodes are warranted, and these methods may have applications for bladder stimulation following SCI.

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Section: Discussionmentioning

confidence: 99%

Effective methods of pelvic plexus nerve and bladder stimulation in anesthetized animal model

Bresler

Walter²,

Jahoda³

et al. 2008

JRRD

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“…Our injection technique is well tolerated and has been previously reported [17]. The procedure is performed in an office setting after 40 ml of 2% lidocaine is instilled into the bladder via a 14 Fr urethral Foley catheter.…”

Section: Injection Techniquementioning

confidence: 99%

Role of botulinum toxin-A in refractory idiopathic overactive bladder patients without detrusor overactivity

et al. 2011

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“…Injections can be performed under local or general anesthesia. The possibility of using no anesthesia at all is also being tested [12] . In terms of injection technique, a comparative study showed a significantly better effect after 9 months when BTX was injected into the detrusor muscle compared to injection into the bladder suburothelium.…”

Section: Treatment Protocolmentioning

confidence: 99%

Current Information on Sacral Neuromodulation and Botulinum Toxin Treatment for Refractory Idiopathic Overactive Bladder Syndrome: A Review

Leong

Wachter

Kerrebroeck³

2010

Urol Int

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The overactive bladder syndrome (OAB) negatively affects the daily life of many people. Conservative treatments, such as antimuscarinics, do not always lead to sufficient improvement of the complaints and/or are often associated with considerable side effects resulting in treatment failure. In the case of failure or intolerable side effects, sacral neuromodulation (SNM) and botulinum toxin are minimally invasive and reversible alternatives. Currently, of these alternatives only SNM with InterStimTM therapy has FDA approval for use in OAB patients. This review attempts to provide an update on the current position of SNM and botulinum toxin in the second-line management of adults with idiopathic OAB, based on the available clinical evidence concerning the efficacy and safety.

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Safety and Tolerability of Sedation-Free Flexible Cystoscopy for Intradetrusor Botulinum Toxin-A Injection

Abstract: Sedation-free intradetrusor botulinum toxin-A injection using intravesical lidocaine and flexible endoscopy is a well tolerated and safe procedure to perform in an office setting.

Cited by 47 publications

References 17 publications

Effective methods of pelvic plexus nerve and bladder stimulation in anesthetized animal model

Effective methods of pelvic plexus nerve and bladder stimulation in anesthetized animal model

Role of botulinum toxin-A in refractory idiopathic overactive bladder patients without detrusor overactivity

Current Information on Sacral Neuromodulation and Botulinum Toxin Treatment for Refractory Idiopathic Overactive Bladder Syndrome: A Review

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