Safety and Tolerability of High-Intensity Focused Ultrasonography for Noninvasive Body Sculpting: 24-Week Data From a Randomized, Sham-Controlled Study

Jewell, Mark L.; Weiß, Robert; Baxter, Richard A.; Cox, Sue Ellen; Dover, Jeffrey S.; Donofrio, Lisa; Glogau, Richard G.; Kane, Michael C.; Martin, Patrick; Lawrence, Ira; Schlessinger, Joel

doi:10.1177/1090820x12455190

Cited by 46 publications

(51 citation statements)

References 10 publications

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“…The most adverse effects of treatment were pain, ecchymosis and swelling. Post-treatment follow-up at 12 and 24 weeks revealed no significant changes in cholesterol, triglycerides, free fatty acids, markers of inflammation and liver or renal function (24). Moreover Jewell et al confirmed HIFU as a useful method for reducing waist circumference.…”

Section: Resultsmentioning

confidence: 99%

Review of the Mechanisms and Effects of Noninvasive Body Contouring Devices on Cellulite and Subcutaneous Fat

Alizadeh

Halabchi

Mazaheri

et al. 2016

Int J Endocrinol Metab

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ContextToday, different kinds of non-invasive body contouring modalities, including cryolipolysis, radiofrequency (RF), low-level laser therapy (LLLT), and high-intensity focused ultrasound (HIFU) are available for reducing the volume of subcutaneous adipose tissue or cellulite. Each procedure has distinct mechanisms for stimulating apoptosis or necrosis adipose tissue. In addition to the mentioned techniques, some investigations are underway for analyzing the efficacy of other techniques such as whole body vibration (WBV) and extracorporeal shockwave therapy (ESWT). In the present review the mechanisms, effects and side effects of the mentioned methods have been discussed. The effect of these devices on cellulite or subcutaneous fat reduction has been assessed.Evidence AcquisitionWe searched pubmed, google scholar and the cochrane databases for systemic reviews, review articles, meta-analysis and randomized clinical trials up to February 2015. The keywords were subcutaneous fat, cellulite, obesity, noninvasive body contouring, cryolipolysis, RF, LLLT, HIFU, ESWT and WBV with full names and abbreviations.ResultsWe included seven reviews and 66 original articles in the present narrative review. Most of them were applied on normal weight or overweight participants (body mass index < 30 kg/m2) in both genders with broad range of ages (18 to 50 years on average). In the original articles, the numbers of included methods were: 10 HIFU, 13 RF, 22 cryolipolysis, 11 LLLT, 5 ESWT and 4 WBV therapies. Six of the articles evaluated combination therapies and seven compared the effects of different devices.ConclusionsSome of the noninvasive body contouring devices in animal and human studies such as cryolipolysis, RF, LLLT and HIFU showed statistical significant effects on body contouring, removing unwanted fat and cellulite in some body areas. However, the clinical effects are mild to moderate, for example 2 - 4 cm circumference reduction as a sign of subcutaneous fat reduction during total treatment sessions. Overall, there is no definitive noninvasive treatment method for cellulite. Additionally, due to the methodological differences in the existing evidence, comparing the techniques is difficult.

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Section: Resultsmentioning

confidence: 99%

Review of the Mechanisms and Effects of Noninvasive Body Contouring Devices on Cellulite and Subcutaneous Fat

Alizadeh

Halabchi

Mazaheri

et al. 2016

Int J Endocrinol Metab

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“…This ability of FUS to reduce fat was recognized by the cosmetic industry and is the most commercially successful use of FUS in humans, with several commercial devices on the market [344, 345]. Similarly, the use of focal thermal coagulation for the shrinkage of tissue has been investigated for skin-tightening using an FDA-approved device [346, 347].…”

Section: Future Developmentsmentioning

confidence: 99%

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

Hynynen¹,

Jones²

2016

Phys. Med. Biol.

106

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Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the body, which can be harnessed for a broad spectrum of therapeutic purposes, including tissue ablation, the targeting of therapeutic agents, and stem cell delivery. Phased array transducers enable electronic control over the beam geometry and direction, and can be tailored to provide optimal energy deposition patterns for a given therapeutic application. Their use in combination with modern medical imaging for therapy guidance allows precise targeting, online monitoring, and post-treatment evaluation of the ultrasound-mediated bioeffects. In the past there have been some technical obstacles hindering the construction of large aperture, high-power, densely-populated phased arrays and, as a result, they have not been fully exploited for therapy delivery to date. However, recent research has made the construction of such arrays feasible, and it is expected that their continued development will both greatly improve the safety and efficacy of existing ultrasound therapies as well as enable treatments that are not currently possible with existing technology. This review will summarize the basic principles, current statures, and future potential of image-guided ultrasound phased arrays for therapy.

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“…Desse modo, o grau de satisfação do paciente baseado nas mudanças estéticas ocorridas após o tratamento é um dos fatores que devem ser levados em consideração na rotina clínica. Jewell et al 20 destacam a importância do registro fotográfico em diferentes momentos, bem como a auto percepção corporal pós tratamento como método avaliativo. Porém, uma ferramenta acurada a fim de mensurar quantitativamente as alterações ocorridas é salutar para a determinação da eficácia da intervenção.…”

Section: Discussionunclassified

Ultracavitação E Triglicerídeos Plasmáticos: Estudo Piloto De Intervenção

Diogo¹,

Santos²,

Félix³

et al. 2017

Rev Pesq Fisio

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Introdução. A ultracavitação (UC) é uma das técnicas não invasiva frequentemente utilizada para redução da gordura localizada. A maioria dos estudos envolvendo este tipo de recurso tem como desfecho primário as alterações estéticas ocorridas, pouco se investigando as alterações relacionadas ao metabolismo lipídico. Objetivo. Descrever a resposta dos triglicerídeos de homens submetidos a sessões de UC. Materiais e Métodos. Incluídos homens com idade entre 40 e 50 anos, circunferência abdominal (CA) > 90 cm, classificados como ativos ou sedentários. Excluídos indivíduos dislipidêmicos, diabéticos, tabagistas, com alterações hepáticas e/ou renais, doenças cardiovasculares, em uso de medicações emagrecedoras e/ou termogênicas ou que já tivessem realizado algum tratamento estético para adiposidade abdominal. Os indivíduos foram divididos em grupo ativo (GA) e sedentário (GS) e submetidos a oito sessões de UC em região abdominal e flancos com intervalo de sete dias entre elas. Coletadas amostras sanguíneas imediatamente antes e 24h após cada sessão para dosagem dos triglicerídeos plasmáticos (TG). Resultados. Avaliados seis indivíduos. Houve elevação na média dos TG entre a primeira e oitava sessão de 17mg/dL no GS, enquanto no GA foi de 34 mg/dL. Já em relação a CA houve uma redução média de 4cm no GS, enquanto que no GA esta redução foi de 8cm. Conclusão. Sessões de UC aumentam os TG de homens saudáveis, independente do nível de atividade física.

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Safety and Tolerability of High-Intensity Focused Ultrasonography for Noninvasive Body Sculpting: 24-Week Data From a Randomized, Sham-Controlled Study

Abstract: This HIFU device exhibited an AE profile similar to that of sham treatment. There were no significant changes from baseline in laboratory values, including lipid levels.

Cited by 46 publications

References 10 publications

Review of the Mechanisms and Effects of Noninvasive Body Contouring Devices on Cellulite and Subcutaneous Fat

Review of the Mechanisms and Effects of Noninvasive Body Contouring Devices on Cellulite and Subcutaneous Fat

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

Ultracavitação E Triglicerídeos Plasmáticos: Estudo Piloto De Intervenção

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