Safety and Reactogenicity of the ChAdOx1 (AZD1222) COVID-19 Vaccine in Saudi Arabia

Bahrani, Salma Al; Albarrak, Ali; Alghamdi, Othman Ali; Alghamdi, Mesfer Abdullah; Hakami, Fatimah H.; Abaadi, Asmaa K. Al; Alkhrashi, Sausan A.; Alghamdi, Mansour Y.; Almershad, Meshael M.; Alenazi, Mansour Moklif; Gezery, Mohamed Hany El; Jebakumar, Arulanantham Zechariah; Al‐Tawfiq, Jaffar A.

doi:10.1016/j.ijid.2021.07.052

Cited by 46 publications

(52 citation statements)

References 18 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…About 35% of receivers of AZD1222, reported at least one side effect after vaccination. The most common side effects were: injection site pain (30.5%), fever (31.3%), muscle symptoms (27.5%), gastrointestinal symptoms (23.8%), and skin rash (19.2%), which consistent with our result [26] . Similar to our study female more likely to report injection site pain, and men were more likely to report skin rash (81.1%), fever (76.9%), and injection site pain (77.3%) [26] .…”

Section: Discussionsupporting

confidence: 90%

“…The most common side effects were: injection site pain (30.5%), fever (31.3%), muscle symptoms (27.5%), gastrointestinal symptoms (23.8%), and skin rash (19.2%), which consistent with our result [26] . Similar to our study female more likely to report injection site pain, and men were more likely to report skin rash (81.1%), fever (76.9%), and injection site pain (77.3%) [26] . Similar to our finding, Cerino et al, reported muscle symptoms (28.2 %), headache (26.8 %), fatigue (20.8 %), fever (17.9 %), chills (14.9 %), and injection site pain (8.9 %) as the most common side effects among a group of adults who received one dose of AZD1222 [27] .…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Prevalence of COVID-19 vaccines (Sputnik V, AZD-1222, and Covaxin) side effects among healthcare workers in Birjand city, Iran

Zare

Rezapour

Mahmoodzadeh

et al. 2021

International Immunopharmacology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Prevalence of COVID-19 vaccines (Sputnik V, AZD-1222, and Covaxin) side effects among healthcare workers in Birjand city, Iran

Zare

Rezapour

Mahmoodzadeh

et al. 2021

International Immunopharmacology

View full text Add to dashboard Cite

“…This finding also agrees with other findings and confirms that the development of post-vaccinal side effects were significantly higher in females than in males (23,24,29). However, it disagrees with a recent study (30) that reported that males TABLE 4 | Comparison between the post vaccine adverse effects after vaccination with BNT162b2 and ChAdOx1 as well as those after the first and the second doses of BNT162b2.…”

Section: Discussionsupporting

confidence: 84%

BNT162b2 and ChAdOx1 SARS-CoV-2 Post-vaccination Side-Effects Among Saudi Vaccinees

et al. 2021

View full text Add to dashboard Cite

Background: Vaccination against SARS-CoV-2 is important for reducing hospitalization and mortalities. Both Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) vaccines are used in Saudi Arabia and in many parts of the world. Post-vaccinal side effects were recorded, so we aimed to screen different complaints after vaccination among vaccinees in Saudi Arabia.Methods: An online questionnaire was designed to screen the local, systemic, and allergic post vaccination reactions for vaccinees who received either one or two doses of the BNT162b2 vaccine or one dose of the ChAdOx1 vaccine. The number and percentage were recorded for each response and analyzed using cross-tab and Chi square tests. The degree of the severity of post vaccination reactions were analyzed using Roc curve. The cofactors that may affect the severity of post-vaccinal reactions including previous COVID-19 infection, age, sex, body mass index, and comorbidities were investigated.Results: During our study, 4,170 individuals reported their responses: 2,601 received one dose of BNT162b2, of whom 456 completed the second dose, and 1,569 received a single dose of ChAdOx1. The side effects were reported in 85.6% of BNT162b2 vaccinees and 96.05% of ChAdOx1 vaccinees who voluntarily responded to a survey about post-vaccination side effects. The side effects were more severe in BNT162b2 than ChAdOx1. ChAdOx1 vaccinees reported mild, moderate, severe and critical side effects in 30.13, 28.62, 29.73, and 1.53%, respectively. In contrast, mild side effects were recorded among the majority of BNT162b2 vaccinees (63.92%) while moderate, severe, and critical side effects were 27.67, 7.68, and 0.72%, respectively. Both local and systemic side effects were recorded more frequently in ChAdOx1 in comparison to BNT162b2 vaccinees. Palpitation was among the new systemic side effects reported in the current study in high frequency. Abnormal menstrual cycle (delaying/increase hemorrhages or pain) was also reported in 0.98% (18/1846) of Pfizer-BioNTech and 0.68% (7/1028) of ChAdOx1 vaccinees, while deep vein thrombosis was only reported in a single case vaccinated with BNT162b2 vaccine.Conclusion: Both vaccines induced post-vaccinal side effects; however, ChAdOx1 induces a higher frequency of post-vaccinal systemic side effects than BNT162b2.

show abstract

“…A retrospective descriptive study using spontaneous reports showed that thrombotic adverse reactions were associated with the COVID-19 AstraZeneca vaccine, in which approximately double the number of occurrences of potential thrombotic events reported in women (n = 19) than men (n = 9) (18). In contrast, a cross-sectional study in Saudi Arabia showed that men were more likely to report fever, skin rash, and pain at the injection site following the first dose of the AstraZeneca (AZD1222) COVID-19 vaccine (19). Therefore, sex disparity in adverse reactions to vaccines may be related to the type of vaccine and the severity of the adverse reaction.…”

Section: Discussion Clinical Implicationsmentioning

confidence: 99%

Sex Differences in Adverse Reactions to an Inactivated SARS-CoV-2 Vaccine Among Medical Staff in China

Zhu

Zhang

Chien³

et al. 2021

Front. Med.

View full text Add to dashboard Cite

Objective: We investigated whether there were sex differences in adverse reactions to an inactivated SARS-CoV-2 vaccine among medical staff in China.Methods: From 24 February to 7 March 2021 an online cross-sectional survey was conducted with a self-administered COVID-19 vaccine questionnaire among medical staff in Taizhou, China. In total, 1397 interviewees (1,107 women and 290 men) participated in the survey.Results: In our study, 178 (16.1%) women and 23 (7.9%) men reported adverse reactions following their first vaccination, and 169 (15.3%) women and 35 (12.1%) men reported adverse reactions following their second vaccination. After adjusting for confounding factors, adverse reactions to other vaccines, worry about adverse reactions, knowledge of the inactivated vaccine being used in the hospital, taking the vaccine for one's family proactively and receiving an influenza vaccination were significantly related to adverse reactions to both injections in women. In contrast, in men, concerns about adverse reactions independently increased the risk of adverse reactions following either vaccination, and a history of adverse reactions to other vaccines also increased the risk of adverse reactions to both injections.Conclusions: Sex differences in the frequency of reported adverse reactions to an inactivated SARS-CoV-2 vaccine and potential factors were demonstrated in a sample of medical staff.

show abstract

Safety and Reactogenicity of the ChAdOx1 (AZD1222) COVID-19 Vaccine in Saudi Arabia

Cited by 46 publications

References 18 publications

Prevalence of COVID-19 vaccines (Sputnik V, AZD-1222, and Covaxin) side effects among healthcare workers in Birjand city, Iran

Prevalence of COVID-19 vaccines (Sputnik V, AZD-1222, and Covaxin) side effects among healthcare workers in Birjand city, Iran

BNT162b2 and ChAdOx1 SARS-CoV-2 Post-vaccination Side-Effects Among Saudi Vaccinees

Sex Differences in Adverse Reactions to an Inactivated SARS-CoV-2 Vaccine Among Medical Staff in China

Contact Info

Product

Resources

About