Safety and pharmacodynamics of intranasal <scp>GSK</scp>2245035, a <scp>TLR</scp>7 agonist for allergic rhinitis: A randomized trial

Ellis, Anne K.; Tsitoura, Daphne C.; Quint, Diana; Powley, William; Lee, Laurie A.

doi:10.1111/cea.12974

Cited by 30 publications

(34 citation statements)

References 43 publications

(87 reference statements)

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“…Compounds from this group, such as imiquimod, are currently used therapeutically in certain circumstances to target melanoma. A novel imidazoquinoline compound, GSK2245035, has been demonstrated to suppress allergic activity in in vitro human assays and has been well tolerated in early‐phase clinical trials …”

Section: Adjuvants In Allergen‐specific Immunotherapymentioning

confidence: 99%

Allergen Immunotherapy in Children User’s Guide

Alvaro‐Lozano

Akdiş

Alviani

et al. 2020

Pediatric Allergy Immunology

192

240

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Aim and scopePediatric Allergy and Immunology publishes original contributions and comprehensive reviews related to the understanding and treatment of immune defi ciency, allergic infl ammatory and infectious diseases in children. Other areas of interest include development of specifi c and accessory immunity, and the immunological interaction during pregnancy and lactation between mother and child. As the journal is intended to promote communication between scientists engaged in basic research and clinicians working with children, both clinical and experimental work will be published.

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Section: Adjuvants In Allergen‐specific Immunotherapymentioning

confidence: 99%

Allergen Immunotherapy in Children User’s Guide

Alvaro‐Lozano

Akdiş

Alviani

et al. 2020

Pediatric Allergy Immunology

192

240

View full text Add to dashboard Cite

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“…TLR7 and TLR8 are functionally active in the endosomal compartment, use MyD88 adapter molecules and are activated by single‐stranded RNA (ssRNA) . Majority of ligands in clinical trials that target TLR7/8 are small molecules (eg, imiquimod [R837], resiquimod, or GSK2245035), and most are derivatives of imidazoquinoline, a tricyclic organic molecule . (Tables ).…”

Section: Therapeutic Interventions Targeting Tlrsmentioning

confidence: 99%

Recent clinical trends in Toll‐like receptor targeting therapeutics

Anwar

Shah

Kim

et al. 2018

Medicinal Research Reviews

215

204

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Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational targets in clinics; thus, many ligands and biologics have been reported to overcome the progression of various inflammatory and malignant conditions and support the immune system. For each TLR, at least one, and often many, drug formulations are being evaluated. Ligands reported as stand‐alone drugs may also be reported based on their use in combinatorial therapeutics as adjuvants. Despite their profound efficacy in TLR‐modulation in preclinical studies, multiple drugs have been terminated at different stages of clinical trials. Here, TLR modulating drugs that have been evaluated in clinical trials are discussed, along with their mode of action, suggestive failure reasons, and ways to improve the clinical outcomes. This review presents recent advances in TLR‐targeting drugs and provides directions for more successful immune system manipulation.

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“…24 Both had similar efficacies. 26 Meanwhile, Berrings and colleagues describe how probiotics-impregnated bedding covers reduced house dust mite allergic rhinitis symptoms although allergens levels were not altered. Vicaut and colleagues use data from five previous trials to compare end-points.…”

Section: Rhinitismentioning

confidence: 99%

“…Ellis and colleagues described a beneficial effect of an intranasal TLR7 agonist (GSK2245035). 26 Meanwhile, Berrings and colleagues describe how probiotics-impregnated bedding covers reduced house dust mite allergic rhinitis symptoms although allergens levels were not altered. 27 2 | CLINICAL ALLERGY…”

Section: Rhinitismentioning

confidence: 99%