Safety and Performance of Targeted Renal Therapy: The Be-RITe! Registry

Weisz, Giora; Filby, Steven J.; Cohen, Mauricio G.; Allie, David E.; Weinstock, Barry S.; Kyriazis, Dimitris K.; Walker, Craig M.; Moses, Jeffrey W.; Danna, Paolo; Fearon, William F.; Sachdev, Naveen; Wiechmann, Bret N.; Vora, Kishor; Findeiss, Laura; Price, Matthew J.; Mehran, Roxana; Leon, Martin B.; Teirstein, Paul S.

doi:10.1583/08-2515.1

Cited by 36 publications

(28 citation statements)

References 37 publications

(45 reference statements)

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“…An attempt to minimize systemic hypotension by direct infusion of fenoldopam into the renal arteries has shown some promise in a proof-ofconcept trial 34 and an observational database. 35 …”

Section: Reversal Of Medullary Blood Flow Reductionmentioning

confidence: 99%

Contrast-Induced Acute Kidney Injury

2010

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Section: Reversal Of Medullary Blood Flow Reductionmentioning

confidence: 99%

Contrast-Induced Acute Kidney Injury

2010

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“…55,72 Recent findings derived from larger investigations have shown that fenoldopam can reduce the incidence of ICAinduced nephropathy, especially if administered directly into the renal arteries. [73][74][75] Direct administration into the renal vasculature has been shown to reduce the risk of systemic hypotension, possibly allowing higher doses of fenoldopam to reach the kidneys while avoiding systemic hypotension. Other agents, such as adenosine receptor antagonists and calcium channel antagonists, show mixed and inconsistent results in reducing the incidence of contrast-induced nephropathy.…”

mentioning

confidence: 99%

Clinical Pharmacology, Uses, and Adverse Reactions of Iodinated Contrast Agents: A Primer for the Non-radiologist

Pasternak

Williamson

2012

Mayo Clinic Proceedings

148

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Iodinated contrast agents have been in use since the 1950s to facilitate radiographic imaging modalities. Physicians in almost all specialties will either administer these agents or care for patients who have received these drugs. Different iodinated contrast agents vary greatly in their properties, uses, and toxic effects. Therefore, clinicians should be at least superficially familiar with the clinical pharmacology, administration, risks, and adverse effects associated with iodinated contrast agents. This primer offers the non-radiologist physician the opportunity to gain insight into the use of this class of drugs.

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“…Targeted renal therapy with direct delivery of such agents to the kidneys via renal arteries during interventional radiological procedures has been reported to overcome such potential limitations [48]. Reduction in the incidence of CI-AKI has been reported with its use [49]. However, its efficacy and safety remains untested in a planned RCT and hence is not recommended [6].…”

Section: Prophylactic Measures Against Ci-akimentioning

confidence: 99%

Contrast Medium-Induced Acute Kidney Injury

et al. 2015

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Contrast medium-induced acute kidney injury (CI-AKI) is a predominant cause of hospital-acquired renal insufficiency. With an increasing number of contrast medium-enhanced radiological procedures being performed in a rapidly increasing ageing population in the Western world, it is imperative that more attention is given to understand the aetiology of CI-AKI to devise novel diagnostic methods and to formulate effective prophylactic and therapeutic regimens to reduce its incidence and its associated morbidity and mortality. This article presents high-yield information on the above-mentioned aspects of CI-AKI, primarily based on results of randomised controlled trials, meta-analyses, systematic reviews and international consensus guidelines.

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Safety and Performance of Targeted Renal Therapy: The Be-RITe! Registry

Abstract: The Benephit system and TRT during coronary and endovascular procedures in patients at high risk for renal failure is simple to use and safe. With the infusion of intrarenal fenoldopam, the incidence of CIN was significantly lower than predicted by risk score calculations.

Cited by 36 publications

References 37 publications

Contrast-Induced Acute Kidney Injury

Contrast-Induced Acute Kidney Injury

Clinical Pharmacology, Uses, and Adverse Reactions of Iodinated Contrast Agents: A Primer for the Non-radiologist

Contrast Medium-Induced Acute Kidney Injury

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