Safety and efficacy of simultaneous use of Mifepristone and Misoprostol in second trimester termination of pregnancy

Jahagirdar, Sayali; Junghare, Pushpa

doi:10.18203/2320-1770.ijrcog20150711

Cited by 2 publications

(6 citation statements)

References 5 publications

(5 reference statements)

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“…Mean gestational age was 17.1 weeks in Mifepristone group and 17.4 weeks in Cerviprime group as seen in the study by Singh V and Carbonella [6,8] . The mean induction abortion interval was 10.7 hrs in Mifepristone group and 13.7 hrs in Cerviprime group which is comparable to study by Jahagirdar SS [7] and Chai J [9] . IA interval was lesser in the Mifepristone group and is statistically significant with p value of 0.0008.the similar findings were seen in study by Patel [10] and Kapp N [11] .…”

Section: Discussionsupporting

confidence: 84%

“…This study compared combination of Mifepristone and misoprostol with combination of cerviprime and misoprostol. The mean age of patient was 27 years in mifepristone group and 26.6 years in cerviprie group which was also the case in other studies [6,7] . Mean gestational age was 17.1 weeks in Mifepristone group and 17.4 weeks in Cerviprime group as seen in the study by Singh V and Carbonella [6,8] .…”

Section: Discussionsupporting

confidence: 82%

“…IA interval was lesser in the Mifepristone group and is statistically significant with p value of 0.0008.the similar findings were seen in study by Patel [10] and Kapp N [11] . Both the regimens were 100% successful as none of the patient required to undergo hysterotomy as seen in other study [7] . In Mifepristone group 82% aborted in 12hrs and 100% in 16 hrs.…”

Section: Discussionsupporting

confidence: 53%

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Use of mifepristone plus misoprostol vs cerviprime plus misoprostol for second trimester abortion: A prospective comparative study

Singh¹,

Saha²,

Aziz³

et al. 2019

Int. J. Clin. Obstet. Gynaecol.

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Background: The complications of abortion increase with the advancing gestational age. The search for the best and most reliable method for second trimester abortion is still ongoing. A prospective comparative study was conducted at a tertiary care hospital in Delhi from 01 Sep 2017 to 31 Aug 2018 with an aim to find out an effective method of second trimester abortion within reasonable time and fewer complications. Study: A total of 70 patients were studied to compare combination of Mifepristone and misoprostol Vs cerviprime and misoprostol for second trimester abortion. The end point of the study was complete abortion with expulsion of placenta. The Induction abortion interval, success rate, side effects and complications were compared between the two groups. Results: There was a significant difference in the IAI in both the groups. The mean Induction to abortion interval was 10.7 hrs in the Mifepristone + misoprostol group and 13.7 hrs in the Cerviprime + misoprostol group. The success rate was 100% in each arm, none of the patients required hysterotomy. More side effects were seen in the cerviprime + misoprostol group. Conclusions: Mifepristone followed by misoprostol and Cerviprime followed by misoprostol are effective methods for second trimester abortion, but mifepristone + misoprostol has the advantage of having lesser Induction to abortion interval and fewer side effects.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 53%

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Use of mifepristone plus misoprostol vs cerviprime plus misoprostol for second trimester abortion: A prospective comparative study

Singh¹,

Saha²,

Aziz³

et al. 2019

Int. J. Clin. Obstet. Gynaecol.

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“…In a study by Madhuri N. et al [6] age groups ranged between 19 and 35 years. In a study by Jahagirdar SS et al [7], the mean age distribution was 26.77 years. In a study by Kulkarni K. K. [8] mean age distribution was 20-38 years in both groups.…”

Section: Discussionmentioning

confidence: 90%

“…In a study by Akkenapally P. L. [11], the mean IAI was 6.19 hours in the mifepristone-primed group compared to 10.69 hours in the misoprostol group. In a study done by Madhuri N et al [6], [7], the mean IAI was 13hrs. In a study by Kulkarni K.K.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of second trimester termination of pregnancy with mifepristone and misoprostol vs misoprostol alone in 50 cases

Swathi¹,

Andallu

Balasaraswathi

et al. 2022

Eureka: HS

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The aim: To study the efficacy and safety of combined mifepristone and misoprostol used in second-trimester abortion(≥ 12 and ≤ 20 weeks) in comparison with only vaginal misoprostol. Materials and methods: This study was a prospective comparative randomised clinical study in women attending hospitals in need of a second-trimester abortion, i.e., 12–20 weeks of pregnancy were taken up and divided as Group A – 50 women with mifeprisptone and misoprostol, Group B – 50 women with misoprostol alone Results were analysed according to age, parity, gestational age, average dose of misoprostol required for complete abortion, Induction abortion interval, completeness of abortion, side effects and mean days of hospital stay. Results: Demographic details are comparable and insignificant in the comparison. The average dose of misoprostol (mcg) required for the completeness of abortion in group A is 596±28.28 mcg, and in group B, it is 1148±160.66 mcg (p<0.001) which is statistically significant. In the present study, the induction abortion interval is significantly less in group A compared to group B, with p<0.001. In addition, 10 out of 50 patients in group A aborted within 7 hours, whereas none in group B. Mean duration of hospital stay in group A is 24 hours. In group B, it is 34.82 hours which is statistically significant with a p-value of <0.001. 12 patients in group A and 26 in group B had side effects like nausea, vomiting, fever, headache and diarrhoea. 8 % of group A and 20 % of group B had a fever. These patients were treated with antipyretics. 6 % in group A and 14 % in group B had nausea and vomiting and were treated with antiemetics. 4 % in group A and 8 % in group B had diarrhoea and were treated with antimotility drugs. 6 % in group A and 10 % in group B had a headache; these patients were treated with NSAIDs. Conclusions: The combination of mifepristone and misoprostol is a highly effective and safe method for second-trimester termination of pregnancy. The amount of misoprostol needed to accomplish the abortion, and the severity of the adverse effects are lower in the mifepristone-primed group than in the misoprostol-alone group. Since there are fewer difficulties, this approach can be employed in hospitals with high patient density.

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Safety and efficacy of simultaneous use of Mifepristone and Misoprostol in second trimester termination of pregnancy

Cited by 2 publications

References 5 publications

Use of mifepristone plus misoprostol vs cerviprime plus misoprostol for second trimester abortion: A prospective comparative study

Use of mifepristone plus misoprostol vs cerviprime plus misoprostol for second trimester abortion: A prospective comparative study

A comparative study of second trimester termination of pregnancy with mifepristone and misoprostol vs misoprostol alone in 50 cases

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