Safety and Efficacy of Sequential Transcatheter Arterial Chemoembolization and Portal Vein Embolization prior to Major Hepatectomy for Patients with HCC

Xu, Chun‐Fang; Lv, Peng-Hua; Huang, Xin-En; Wang, Shuxiang; Sun, Liankang; Wang, Fuan; Wang, Lifu

doi:10.7314/apjcp.2014.15.2.703

Cited by 25 publications

(15 citation statements)

References 26 publications

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“…Improvement in liver function by biliary drainage may provide symptomatic relief and allow for antitumor therapies, including transhepatic chemoembolization (TACE) and chemotherapy (Cui et al, 2012;Li et al, 2012;Mao et al, 2012;Kong et al, 2012;Xiong et al, 1 2012; Ma et al, 2013;Wang et al, 2013;Wang et al, 2013;Jong et al, 2013;Xu et al, 2014). Percutaneous Transhepatic Catheter Drainage (pTCD)/ Percutaneous Transhepatic Biliary Stengting (pTBS) is a method of biliary tree decompression, applied as palliative treatment in patients with inoperable malignant biliary obstruction.…”

Section: Introductionmentioning

confidence: 99%

Drainage Alone or Combined with Anti-tumor Therapy for Treatment of Obstructive Jaundice Caused by Recurrence and Metastasis after Primary Tumor Resection

Huang²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Aim: To compare drainage alone or combined with anti-tumor therapy for treatment of obstructive jaundice caused by recurrence and metastasis after primary tumor resection. Materials and Methods: We collect 42 patients with obstructive jaundice caused by recurrence and metastasis after tumor resection from January 2008 -August 2012, for which percutaneous transhepatic catheter drainage (pTCD)/ percutaneous transhepatic biliary stenting (pTBS) were performed. In 25 patients drainage was combined with anti-tumor treatment, antineoplastic therapy including intra/postprodure local treatment and postoperative systemic chemotherapy, the other 17 undergoing drainage only. We assessed the two kinds of treatment with regard to patient prognosis. Results: Both treatments demonstrated good effects in reducing bilirubin levels in the short term and promoting liver function. The time to reobstruction was 125 days in the combined group and 89 days in the drainage only group; the mean survival times were 185 and 128 days, the differences being significant. Conclusions: Interventional drainage in the treatment of the obstructive jaundice caused by recurrence and metastasis after tumor resection can decrease bilirubin level quickly in a short term and promote the liver function recovery. Combined treatment prolongs the survival time and period before reobstruction as compared to drainage only.

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Section: Introductionmentioning

confidence: 99%

Drainage Alone or Combined with Anti-tumor Therapy for Treatment of Obstructive Jaundice Caused by Recurrence and Metastasis after Primary Tumor Resection

Huang²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…One study found that the FLR after sequential TACE and PVE increased from 32.3% to 71.4% (mean 55.4%). In addition, no patients had intra- or extrahepatic metastasis[19]. A Korean study compared the prognostic impact of preoperative sequential TACE and PVE or PVE alone in patients who underwent right liver resection for solitary HCC [7].…”

Section: Discussionmentioning

confidence: 99%

Liver Injury and Tumor-Inhibiting Effect of Sequential Transcatheter Arterial Chemoembolization and Portal Venous Embolization on Rabbit VX2 Liver Carcinoma

Song

Guo

2017

Med Sci Monit

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BackgroundThe concepts of sequential transcatheter arterial chemoembolization (TACE) and portal venous embolization (PVE) were proposed to prevent the detrimental tumor growth-inducing effect of PVE and to facilitate growth of further future liver remnant (FLR). This study aimed to investigate the effect of sequential TACE and PVE on liver damage and the therapeutic effect in a rabbit VX2 liver tumor model.Material/MethodsRabbits bearing VX2 liver tumors were randomly divided into TACE+PVE, TACE, PVE, and Sham groups. Plasma levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL), and alkaline phosphatase (ALP) at 6 h, 24 h, 3 days, and 7 days were measured by ELISA assay. Tumor diameter on day 7 was measured and the tumor sections with cleaved caspase-3 was stained and observed.ResultsPlasma ALT, AST, and ALP levels were significantly increased at the first hours after the interventions. The TACE group had higher increases than the TACE+PVE and PVE alone groups. ALT, AST, and ALP levels decreased on day 7 and presented a trend to return to the baseline level. The TACE+PVE group showed stronger tumor-inhibiting effect than the TACE and PVE alone groups and also induced the highest level of tumor cell apoptosis.ConclusionsThe liver damage caused by TACE+PVE is mild and recoverable. TACE+PVE showed stronger tumor-inhibiting effect than in the TACE and PVE group and also induced the highest level of tumor cell apoptosis.

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“…The most important factors in choosing optical stratery for TACE are to obtain favorable therapeutic effects and to reduce adverse side-effects (Xu et al, 2014). With regard to the embolic agent used in TACE for HCC, several studies have analyzed the efficacy of lipiodol (Idee and Guiu, 2013;Peng et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Transcatheter arterial chemoembolization (TACE) is an accepted treatment option for unresectable hepatocellular carcinoma (HCC) (Peng et al, 2014;Xu et al, 2014), of which equential TACE could an effective method to improve resection opportunity, expand the scope of surgical resection, as well as to greatly reduce postoperative intra-and extrahepatic metastasis (Xu et al, 2014). However, the long-term effectiveness of TACE remains limited.…”

Section: Discussionmentioning

confidence: 99%

Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model

Weng

Xiang

Lin

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.

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Safety and Efficacy of Sequential Transcatheter Arterial Chemoembolization and Portal Vein Embolization prior to Major Hepatectomy for Patients with HCC

Cited by 25 publications

References 26 publications

Drainage Alone or Combined with Anti-tumor Therapy for Treatment of Obstructive Jaundice Caused by Recurrence and Metastasis after Primary Tumor Resection

Drainage Alone or Combined with Anti-tumor Therapy for Treatment of Obstructive Jaundice Caused by Recurrence and Metastasis after Primary Tumor Resection

Liver Injury and Tumor-Inhibiting Effect of Sequential Transcatheter Arterial Chemoembolization and Portal Venous Embolization on Rabbit VX2 Liver Carcinoma

Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model

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