Safety and efficacy of novel dermal and epidermal microneedle delivery systems for rabies vaccination in healthy adults

Laurent, Philippe; Bourhy, Hervé; Fantino, Marc; Alchas, Paul; Mikszta, John A.

doi:10.1016/j.vaccine.2010.06.062

Cited by 84 publications

(44 citation statements)

References 39 publications

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“…In another recent study using BD microneedle technology, ID administration of a 25% dose of rabies vaccine resulted in equivalent antibody titers and seroconversion rates to the full im. dose [95].…”

Section: New Devices For Id Vaccinationmentioning

confidence: 99%

Intradermal vaccination for rabies prophylaxis: conceptualization, evolution, present status and future

Madhusudana

Mani

2014

Expert Review of Vaccines

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Rabies is a fatal viral encephalitis which can be effectively prevented by prophylactic measures. The currently available cell culture vaccines used for rabies prophylaxis are expensive for use by the standard intramuscular route of administration. In the last 3 decades, intradermal (ID) routes of vaccination using lesser amounts of vaccine as compared to that used for standard intramuscular vaccination have been used extensively in some Asian countries which has reduced the economic burden of rabies prophylaxis and also contributed in achieving a decline in the incidence of human rabies. ID vaccination is based on sound immunological principles and has been found to be safe and immunogenic. New short duration regimens to further economize the cost and enhance patient compliance, and novel non-invasive devices for ID vaccine delivery are being evaluated. Considering the success of ID rabies vaccination in Asian countries, its implementation in rabies endemic African countries should be encouraged.

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Section: New Devices For Id Vaccinationmentioning

confidence: 99%

Intradermal vaccination for rabies prophylaxis: conceptualization, evolution, present status and future

Madhusudana

Mani

2014

Expert Review of Vaccines

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“…The same study also evaluated an epidermal vaccination device (Onvax TM , Becton Dickinson) that did not induce an immune response in the recipients. 18 …”

Section: Current Clinical Researchmentioning

confidence: 99%

Intradermal delivery of vaccines: potential benefits and current challenges

Hickling¹,

Jones²,

Friede

et al. 2011

Bull. World Health Organ.

165

137

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“…These devices scrape the skin with blunt-tipped microneedles and have been used to increase the delivery of an anthrax vaccine in mice and rabbits, 53 a Japanese encephalitis vaccine in cynomolgus monkeys 56 and a rabies vaccine in humans. 57,58 While these devices were shown to be effective, intradermal injection of the vaccine in each of these studies was significantly more effective, potentially due to inefficient delivery into the skin from the formulation. In spite of immunogenicity, the popularity of solid MNs has reduced in recent years, potentially due to the requirement for a multi-step administration process, the lack of consistency and the increased number of advantages of other MN systems.…”

Section: Solid Mnsmentioning

confidence: 99%

The success of microneedle-mediated vaccine delivery into skin

Marshall

Sahm

Moore

2016

Human Vaccines & Immunotherapeutics

118

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Microneedles (MNs) are designed to specifically target the outermost, skin barrier layer, the stratum corneum, creating transient pathways for minimally invasive transcutaneous delivery. It is reported that MNs can facilitate delivery without stimulating the pain receptors or damaging blood vessels that lie beneath, thus being perceived as painless and associated with reduced bleeding. This immunocompetence of the skin, coupled with its ease of access, makes this organ an attractive vaccination site. The purpose of this review was to collate primary scientific literature pertaining to MN-mediated in vivo vaccination programmes. A total of 62 original research articles are presented, compiling vaccination strategies in 6 different models (mouse, rat, guinea pig, rabbit, pig, macaque and human). Vaccines tested span a wide range of viral, bacterial and protozoan pathogens and includes 7 of the 13 vaccine-preventable diseases, as defined by the WHO. This review highlights the paucity of available clinical trial data. MN-delivered vaccines have demonstrated safety and immunogenicity in pre-clinical models and boast desirable attributes such as painless administration, thermostability, dose-sparing capacity and the potential for self-administration. These advantages should contribute to enhanced global vaccine access.

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Safety and efficacy of novel dermal and epidermal microneedle delivery systems for rabies vaccination in healthy adults

Cited by 84 publications

References 39 publications

Intradermal vaccination for rabies prophylaxis: conceptualization, evolution, present status and future

Intradermal vaccination for rabies prophylaxis: conceptualization, evolution, present status and future

Intradermal delivery of vaccines: potential benefits and current challenges

The success of microneedle-mediated vaccine delivery into skin

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