Intradermal delivery of vaccines: potential benefits and current challenges

Hickling, Julian; Jones, KR; Friede, Martin; Zehrung, Darin; Chen, D; Kristensen, Debra

doi:10.2471/blt.10.079426

Cited by 161 publications

(148 citation statements)

References 26 publications

(27 reference statements)

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“…The ID delivery methods that are currently available can be roughly classified into three categories: administration by (1) needle and syringe, (2) jet injectors, and (3) microneedles [12]. An overview of these different ID delivery methods tested in combination with IPV is given in Tables 2 (preclinical) and 3 (clinical).…”

Section: Dermal Immunizationmentioning

confidence: 99%

Alternative administration routes and delivery technologies for polio vaccines

Kraan

Stel

Kersten

et al. 2016

Expert Review of Vaccines

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Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccines. The target product profile of these vaccines includes not only dose sparing but also high stability, which is important for stockpiling, and easy application important for (emergency) vaccination campaigns. In this review, the current status of alternative polio vaccine delivery strategies is given. Furthermore, we discuss the feasibility of these strategies by highlighting challenges, hurdles to overcome, and formulation issues relevant for optimal vaccine delivery. ARTICLE HISTORY

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Section: Dermal Immunizationmentioning

confidence: 99%

Alternative administration routes and delivery technologies for polio vaccines

Kraan

Stel

Kersten

et al. 2016

Expert Review of Vaccines

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show abstract

“…In accordance to this, intradermal vaccination has been found to induce more potent immune responses than that induced by intramuscular injections of various vaccines, including in°uenza, Rabies, etc. 13 Yet, intradermal injection of vaccines is frequently associated with severe local reactions. A number of studies showed that injection of in°uenza vaccines into skin by hypodermal needles caused swelling and erythema lasting for several days.…”

Section: Facilitation Of Cutaneous Delivery Of Vaccines By Laser Techmentioning

confidence: 99%

Laser facilitates vaccination

Wang

Chen

et al. 2016

J. Innov. Opt. Health Sci.

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Development of novel vaccine deliveries and vaccine adjuvants is of great importance to address the dilemma that the vaccine¯eld faces: to improve vaccine e±cacy without compromising safety. Harnessing the speci¯c e®ects of laser on biological systems, a number of novel concepts have been proposed and proved in recent years to facilitate vaccination in a safer and more e±cient way. The key advantage of using laser technology in vaccine delivery and adjuvantation is that all processes are initiated by physical e®ects with no foreign chemicals administered into the body. Here, we review the recent advances in using laser technology to facilitate vaccine delivery and augment vaccine e±cacy as well as the underlying mechanisms.

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“…One of these is the paucity of appropriate adjuvants. 33,34 Most adjuvants used in licensed intramuscular vaccines like aluminum salt and oil-in-water adjuvants are simply too reactogenic when delivered intradermally. 35,36 While some clinical trials have suggested that alum-adjuvanted vaccines are tolerable when given intradermally, 37,38 reports of injection-site reactions with intradermally-delivered adjuvanted vaccines are much higher compared with non-adjuvanted formulations.…”

Section: Potential Role Of Lasers As Vaccine Adjuvantsmentioning

confidence: 99%

“…39 Finally, current adjuvants may not be compatible with intradermal delivery or formulation requirements, especially with newer intradermal vaccination technologies. 33,34 Not surprisingly, there is no adjuvanted intradermal vaccine licensed to date.…”

Section: Potential Role Of Lasers As Vaccine Adjuvantsmentioning

confidence: 99%

“…158,159 Initial pilot studies in humans using volunteers with skin phototypes V and VI have already established the probability that CW-NIR doses used in the mouse models will be tolerable in humans of all skin tones. 33,51 The reduced differences in absorbance across skin phototypes makes the CW-NIR laser ideal for clinical use.…”

Section: Advantages and Limitations Of Laser Vaccine Adjuvantsmentioning

confidence: 99%

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