Safety and efficacy of methylester of conjugated linoleic acid (t10,c12 isomer) for pigs for fattening, sows and cows

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doi:10.2903/j.efsa.2016.4348

Cited by 3 publications

(5 citation statements)

References 91 publications

(241 reference statements)

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“…The diets were formulated to meet or exceed the nutrient requirments recommended by NRC (National research council) for growing rabbits; 2500 Kcal digestible energy/ Kg diet, 16% crude protein, fat 2%, and crude fiber 10–12% [19] ( Table 1 ). Rabbits were blocked for body weight (612.8 ± 24.89 g) and completely randomized into three ( n = 25/group) isonitrogenous, isocaloric dietary treatments: 1) CON group was fed a basal control diet supplemented with 1% oleic acid (Techno Pharmachem, India), 2) CLAL group was fed a diet supplemented with 0.5% isomer-mix CLA (Lutrell Pure; BASF, Ludwigshafen,Germany; certified to contain equal proportion of c 9, t 11- and t 10, c 12-CLA; EFSA, [20, 21] plus 0.5% oleic acid, and 3) CLAH group was fed a diet supplemented with 1% isomer-mix CLA. Oleic acid was added to CON and CLAL diets to have final added lipid source of 1% according to a prior study [22].…”

Section: Methodsmentioning

confidence: 99%

Nutrigenomic effect of conjugated linoleic acid on growth and meat quality indices of growing rabbit

et al. 2019

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Conjugated linoleic acid was detected in rabbit caecotrophs, due to the presence of microbial lipid activity in rabbit cecum. However, the effect of CLA as a functional food in growing rabbit is not well established. Therefore, this study was conducted to determine the effect of CLA on production, meat quality, and its nutrigenomic effect on edible parts of rabbit carcass including skeletal muscle, liver, and adipose tissue. Therefore, seventy five weaned V-Line male rabbits, 30 days old, were randomly allocated into three dietary treatments receiving either basal control diet, diet supplemented with 0.5% (CLAL), or 1% CLA (CLAH). Total experimental period (63 d) was segmented into 7 days adaptation and 56 days experimental period. Dietary supplementation of CLA did not alter growth performance, however, the fat percentage of longissimus lumborum muscle was decreased, with an increase in protein and polyunsaturated fatty acids (PUFA) percentage. Saturated fatty acids (SFA) and mono unsaturated fatty acids (MUFA) were not increased in CLA treated groups. There was tissue specific sensing of CLA, since subcutaneous adipose tissue gene expression of PPARA was downregulated, however, CPT1A tended to be upregulated in liver of CLAL group only (P = 0.09). In skeletal muscle, FASN and PPARG were upregulated in CLAH group only (P ≤0.01). Marked cytoplasmic vacuolation was noticed in liver of CLAH group without altering hepatocyte structure. Adipocyte size was decreased in CLA fed groups, in a dose dependent manner (P <0.01). Cell proliferation determined by PCNA was lower (P <0.01) in adipose tissue of CLA groups. Our data indicate that dietary supplementation of CLA (c9,t11-CLA and t10,c12- CLA) at a dose of 0.5% in growing rabbit diet produce rabbit meat rich in PUFA and lower fat % without altering growth performance and hepatocyte structure.

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Section: Methodsmentioning

confidence: 99%

Nutrigenomic effect of conjugated linoleic acid on growth and meat quality indices of growing rabbit

et al. 2019

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“…Lutalin ® is intended for use in pigs and ruminants whereas Lutrell ® Pure is aimed only for ruminants. More details about the mode of action and the effects of CLA in pigs for fattening, sows and dairy cows are described in a previous opinion (EFSA FEEDAP Panel, 2016).…”

Section: Assessmentmentioning

confidence: 99%

“…According to a literature review conducted by the applicant, 4 the main effects of supplemental methylated CLA would consist of a reduction in fat synthesis and consequent improvement in performance and reproduction of sows and dairy cows (EFSA FEEDAP Panel, 2016).…”

Section: Assessmentmentioning

confidence: 99%

“…This additive has been characterised in a previous scientific opinion (EFSA FEEDAP Panel, 2016). It has two different formulations: À Lutalin ® : a liquid formulation of the additive that contains by specification a minimum of 28% of CLA (t10,c12)-ME.…”

Section: Characterisationmentioning

confidence: 99%

“…In the previous opinion (EFSA FEEDAP Panel, 2016), it was concluded that 'Energy balance (body weight loss) in early lactation is improved by feeding CLA as a consequence of reduced milk fat synthesis. To obtain consistent effects, higher doses (≥ 6.1 g CLA (t10,c12)-ME per cow and day) than for reduced milk fat concentration appear necessary.…”

Section: Efficacy For Cows For Reproductionmentioning

confidence: 99%

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Efficacy of methyl ester of conjugated linoleic acid (t10,c12 isomer) for sows and cows for reproduction

Additives¹,

Bampidis²,

Azimonti³

et al. 2019

EFS2

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A mixture of methylated conjugated linoleic acid (CLA) isomers (t10,c12 and c9,t11) in equal proportions is the subject of this assessment. The active substance is considered to be CLA (t10,c12) methyl ester (ME). The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) of EFSA previously issued an opinion on the safety and efficacy of the product, in which it could not conclude on the efficacy of this additive for sows for reproduction and for cows for reproduction. The European Commission asked EFSA to deliver an opinion on the efficacy of this additive for sows and cows for reproduction, based on additional data submitted by the applicant. The FEEDAP Panel has performed the assessment of the new data following an approach in line with the principles laid down in Regulation (EC) No 429/2008 and the relevant guidance documents. In relation to the data on efficacy in sows for reproduction, owing to methodological shortcomings of the study submitted, including the duration of the study and the limited biological relevance of the effect observed, the FEEDAP Panel cannot conclude on the efficacy of CLA (t10,c12)‐ME for sows for reproduction. The data related to dairy cows indicate that dietary CLA (t10,c12)‐ME supplementation in the late dry period and/or lactation period showed an increase of the probability of pregnancy and a reduction of time to conception in the same reproductive cycle. However, considering that the minimum duration of efficacy studies for reproductive parameters is of at least two reproductive cycles, the FEEDAP Panel is not in a position to conclude on the efficacy of the additive for cows for reproduction.

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Effects of dietary conjugated linoleic acid in broiler breeders and egg storage time on the fatty acid profile, lipid oxidation and internal egg quality

Silvério,

de Lima,

da Silva

et al. 2023

Anim. Prod. Sci.

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Context The need for the storage of fertile eggs is a reality in the poultry industry. At the same time, prolonged storage periods decrease the quality of egg components that are essential for embryo development, and can compromise hatchability and chick quality; thus, the high content of unsaturated fatty acids in embryo tissues increase the susceptibility to peroxidation. Aims The objective of this study was to evaluate the addition of cis-9, trans-11, trans-10 and cis-12 isomers of conjugated linoleic acid (CLA) to the broiler-breeder diet and the storage time on the internal egg quality, composition and lipid oxidation. Methods In total, 22 000 Cobb female broiler breeders of 58 weeks of age were fed with diets containing 0 or 0.024% CLA and fertile eggs were stored 3, 6 or 9 days prior to incubation. In total, 6912 hatching eggs were used in a completely randomised experimental design in a 2 × 3 factorial arrangement (CLA inclusion × egg storage time). At the end of each storage period, 30 eggs per dietary treatment were sampled to analyse yolk and albumen height, percentage and pH, yolk:albumen ratio, yolk diameter and index, Haugh unit (HU), yolk lipid oxidation, acidity and fatty acid profile. Key results The progression of storage negatively affected the internal quality of the eggs; however, inclusion of CLA minimised these effects up to Day 6, especially for yolk diameter, HU, height and albumen pH. The total lipid content was not affected by the dietary treatments; however, CLA inclusion resulted in a higher proportion of stearic acid and a lower concentration of linoleic acid in yolks. Conclusions The changes observed in fatty acid profile of the eggs may have favoured the reduction of lipid oxidation, as shown by the decrease in the acidity index and thiobarbituric acid-reactive substance (TBARS) values at shorter storage periods. Implications The dietary addition of CLA to broiler breeders may be used to preserve the egg internal quality during a short-term storage period.

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Safety and efficacy of methylester of conjugated linoleic acid (t10,c12 isomer) for pigs for fattening, sows and cows

Cited by 3 publications

References 91 publications

Nutrigenomic effect of conjugated linoleic acid on growth and meat quality indices of growing rabbit

Nutrigenomic effect of conjugated linoleic acid on growth and meat quality indices of growing rabbit

Efficacy of methyl ester of conjugated linoleic acid (t10,c12 isomer) for sows and cows for reproduction

Effects of dietary conjugated linoleic acid in broiler breeders and egg storage time on the fatty acid profile, lipid oxidation and internal egg quality

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