Safety and efficacy of fixed‐dose 10 mg daily isotretinoin treatment for acne vulgaris in Malaysia

Yap, Felix Boon-Bin

doi:10.1111/jocd.12268

Cited by 12 publications

(15 citation statements)

References 19 publications

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“…However, these changes do not exceed the normal range. Our findings were consistent with previous studies where low dose isotretinoin has been showed to be beneficial in the treatment and a decrease in relapse [9], [10], [11]. Hence, to minimise the side effects of drugs, the low dose isotretinoin should be considered in the treatment of acne disease.…”

Section: Discussionsupporting

confidence: 92%

“…Another study among 150 Malaysian patients treated with isotretinoin at 10mg on the daily basis until a cumulative dose of 90-110 mg/kg showed that after 24 weeks of treatment, all patients cleared of acne lesions with a low rate of elevated liver enzymes and serum lipid at 3.3% and 2.7% respectively. There was no case of discontinuation in treatment [11]. The hyperhomocysteinemia with low serum folic acid level cause many severe side effects, but there was no study in the literature about this disorder in low-dose isotretinoin therapy.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Oral Low-Dose Isotretinoin in the Treatment of Acne Vulgaris in Vietnam

Van¹,

Minh²,

Thuy³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND:Oral isotretinoin is an effective therapy for acne. However, isotretinoin can induce hyperhomocysteinemia and decreased serum folic acid level, which may be a risk for cardiovascular disease and thrombosis, as well as psychoses. Besides, many recent types of research emphasise the safety and effects of the low dose isotretinoin therapy.AIM:The aim of our study was to evaluate the effect of the low-dose isotretinoin on the plasma homocysteine and serum folic acid level in the Vietnamese population.METHODS:We conducted a longitudinal study to evaluate the effectiveness of the low-dose therapy on the plasma homocysteine and serum folic acid level of 52 acne patients after 6-8-week treatment at University Medical Center Ho Chi Minh City, Viet Nam. Patients had moderate-severe acne with the prolonged course, and most of them had a scar.RESULTS:With a low dose of oral isotretinoin (0.37 ± 0.11 mg/kg/day), after 6-8-week treatment, patients dropped the severity of disease, increased the plasma homocysteine level and decreased the serum folic acid level with significant differences in comparison to those before treatment. However, these changes do not exceed the normal range.CONCLUSION:In overall, low dose isotretinoin treatment had effectiveness in decrease the severity of disease and no increasing the plasma homocysteine level as well as the serum folic acid level.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Efficacy of Oral Low-Dose Isotretinoin in the Treatment of Acne Vulgaris in Vietnam

Van¹,

Minh²,

Thuy³

et al. 2019

Open Access Maced J Med Sci

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“…1,2 Acne vulgaris is a chronic, multifactorial, inflammatory disorder of the sebaceous glands as well as ducts and the hair follicles with a strong genetic predisposition, often presenting in the face, back, and chest. 3,4 Some of the key mechanisms involved in the development of acne include disturbed sebaceous gland activity associated with hyperseborrhea (ie, increased sebum production) and alterations in sebum fatty acid composition, dysregulation of the hormone microenvironment, interaction with neuropeptides, follicular hyperkeratinization, induction of inflammation, and dysfunction of the innate and adaptive immunity. 5 Isotretinoin, a vitamin A derivative, was first approved in the United States in 1982 for the treatment of severe acne.…”

Section: Introductionmentioning

confidence: 99%

Public Understanding and Awareness of Isotretinoin Use and Safety in Al Ahsa, Eastern Saudi Arabia

Younis

Al-Harbi

2019

Ther Innov Regul Sci

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Background: Acne vulgaris, a chronic inflammatory disease, is among the most common dermatologic conditions worldwide. In Saudi Arabia, Isotretinoin is commonly used to treat mild acne even without prescription. Objective: To explore the practice and knowledge of community in Saudi Arabia regarding dispensing, counseling practices, and safety of isotretinoin-containing products. Methods: A cross-sectional survey, using a self-administered questionnaire, was conducted in 3 sections: demographics, self-medication attitude (in the form of self Isotretinoin use), and identifying the side effects associated with the use of isotretinoin. Results: A total of 1069 participated in the study. Around half of the participants (44.2%) used isotretinoin with only mild acne as their first choice, which is contrary to the recommended guidelines. Virtually one-fifth of the participants did not examine the lipid profile, liver enzymes, and blood glucose level before isotretinoin use. Not many participants identified lipid (58.7%) and liver (44.1%) depression (53.3%), inflammatory bowel disease (75.9%), osteoporosis (60.3%), and sunburns (36.3%) as risks allied with isotretinoin use. Most participants (88.9%) appropriately recognized teratogenicity as the greatest hazard concomitant with the use of isotretinoin. Nevertheless, 20% of the women did not know that they must cease the drug at least 6 months before pregnancy. Conclusion: This study shows that community residents are not satisfactorily aware of the proper use and jeopardies of isotretinoin. Therefore, greater consideration ought to be dedicated to augment the safe use of isotretinoin. We recommend the implementation of tools to enhance the safe use of isotretinoin and the imposition of more effective regulations to limit nonprescribed isotretinoin dispensing in Saudi Arabia.

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“…In a prospective study of 150 patients with moderate to severe acne who were treated with 10mg isotretinoin daily to a cumulative dose of 90–110 mg/kg, all patients achieved total clearance with a mean time to clearance of 24 weeks 44 . Twelve months post treatment, “mild” relapse (defined as recurrence of acne after clearance) had occurred in 4% of patients.…”

Section: Dosing Considerationsmentioning

confidence: 99%

Isotretinoin in the management of acne vulgaris: practical prescribing

Fallah

Rademaker

2020

Int J Dermatology

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Since it was first approved for use in 1982, isotretinoin has revolutionized the management of acne vulgaris. Despite almost four decades of widespread use, uncertainty still exists regarding the manner in which it is best prescribed. In this review, we provide an update on the pharmacokinetics, mechanism of action, contraindications, interactions, and appropriate dosing schedule of isotretinoin in the treatment of acne. We also discuss the safety of performing concurrent dermatological procedures in patients taking isotretinoin.

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Safety and efficacy of fixed‐dose 10 mg daily isotretinoin treatment for acne vulgaris in Malaysia

Abstract: Fixed-dose 10 mg daily treatment with isotretinoin until a cumulative dose of 90-110 mg/kg is safe with low relapse rate.

Cited by 12 publications

References 19 publications

Efficacy of Oral Low-Dose Isotretinoin in the Treatment of Acne Vulgaris in Vietnam

Efficacy of Oral Low-Dose Isotretinoin in the Treatment of Acne Vulgaris in Vietnam

Public Understanding and Awareness of Isotretinoin Use and Safety in Al Ahsa, Eastern Saudi Arabia

Isotretinoin in the management of acne vulgaris: practical prescribing

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