Safety and efficacy of cryolipolysis for non‐invasive reduction of submental fat

Kilmer, Suzanne L.; Burns, A. Jay; Zelickson, Brian D.

doi:10.1002/lsm.22440

Cited by 104 publications

(117 citation statements)

References 17 publications

(31 reference statements)

Supporting

Mentioning

106

Contrasting

Order By: Relevance

“…The efficacy of this bilateral submental cryolipolysis procedure was similar to that found in the prior study of central submental cryolipolysis 16 since fat layer reduction was mea- mental treatment study, skinfold caliper data demonstrated a mean (SD) fat layer reduction of 2.3 (0.8) mm. The mean (SD) fat thickness reduction measured via 3-D imaging was 3.77 (3.59) mm in the central submental area.…”

Section: Discussionsupporting

confidence: 72%

“…These participant surveys show higher satisfaction than the previous central submental study, which determined that 83% of participants were satisfied with submental cryolipolysis and 77% reported visible fat reduction. 16 The increased satisfaction in the present study may be a result of enhanced fat reduction since both the central and lateral portions of the submental area were treated, leading to more aesthetically pleasing chin and neck contouring, and to the fact that participants started with more submental fat than the participants in the previous study. However, the present study did not have a single-application control in the central submental area for direct comparison, and these survey results are being compared across studies.…”

Section: Discussionmentioning

confidence: 84%

See 1 more Smart Citation

Safety and Efficacy of Bilateral Submental Cryolipolysis With Quantified 3-Dimensional Imaging of Fat Reduction and Skin Tightening

Bernstein

Bloom

2017

JAMA Facial Plast Surg

View full text Add to dashboard Cite

IMPORTANCE Cryolipolysis is a popular, well-tolerated nonsurgical procedure that uses controlled cooling to selectively destroy fat cells. Central submental cryolipolysis has been reported to be safe and effective, but many patients would benefit from extending this treatment over the entire submental region.OBJECTIVE To investigate the safety and efficacy of cryolipolysis for reduction of lateral and central submental fat. DESIGN, SETTING, AND PARTICIPANTSThe study population consisted of 14 participants who were treated from January 22 to June 30, 2016, in the lateral and central submental area to reduce unwanted subcutaneous fat. A small-volume cup applicator was used to administer 2 cryolipolysis treatments, delivered in 45-minute treatment cycles in 2 sessions. For the first treatment session, all participants received bilateral treatments with approximately 20% overlap of the treatment area. At the 6-week follow-up visit, participants were reassessed to determine whether they would benefit from a second treatment and to determine the number of cycles needed to achieve the optimal aesthetic result, and then they were treated a second time. MAIN OUTCOMES AND MEASURESParticipant surveys assessed tolerability and treatment satisfaction at 12 weeks following the second treatment. Clinicians monitored adverse events to assess safety. Caliper measurements were recorded to assess fat thickness reduction. Treatment efficacy was objectively evaluated using 2-dimensional and 3-dimensional imaging.RESULTS Among the 14 participants (12 women and 2 men; mean [SD] age, 50.5 [10.4] years), the adverse effects of the procedure were typically mild and included numbness and tingling, which resolved without intervention by the final 12-week follow-up visit. An independent review of digital photographs revealed an 81.0% (95% CI, 65.9%-91.4%; P = .02) correct identification rate (34 of 42 images) of the pretreatment and posttreatment images. Caliper measurements demonstrated a mean (SD) fat layer reduction of 2.3 (0.8) mm (range, 0.7-3.5 mm). Three-dimensional imaging revealed a mean (SD) reduction in fat volume of 4.82 (11.42) cm 3 (from a reduction of 32.69 cm 3 to an increase of 13.85 cm 3 ), in skin surface area of 1.29 (1.42) cm 2 (from a reduction of 3.18 cm 2 to an increase of 0.99 cm 2 ), and in fat thickness of 3.77 (3.59) mm (from of reduction of 13.10 mm to an increase of 0.47 mm). Results of participant surveys indicated that 13 participants (93%) were satisfied with the cryolipolysis treatment. CONCLUSIONS AND RELEVANCEAlthough safe and efficacious central submental cryolipolysis has been reported, this is the first clinical study of cryolipolysis for treatment of the entire submental area using overlapping bilateral treatments and a shorter treatment duration. The study demonstrates that bilateral submental cryolipolysis is well tolerated and produces visible and significant fat layer reduction.LEVEL OF EVIDENCE 4.

show abstract

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 84%

Safety and Efficacy of Bilateral Submental Cryolipolysis With Quantified 3-Dimensional Imaging of Fat Reduction and Skin Tightening

Bernstein

Bloom

2017

JAMA Facial Plast Surg

View full text Add to dashboard Cite

show abstract

“…However, the destruction of adipocytes does not affect serum lipid levels or liver function tests significantly. In spite of being a new technology without a fully understood mechanism of action, promising results have been confirmed in studies; therefore, it seems to be an excellent alternative for localized fat reduction without major adverse effects [7–9]. This case report was conducted in order to validate the effects of this therapy in eliminating abdominal fat cells, through histological and ultrasound examinations.…”

Section: Introductionmentioning

confidence: 99%

Effects of Cryolipolysis on Abdominal Adiposity

Meyer

Silva

Oliveira

et al. 2016

Case Reports in Dermatological Medicine

View full text Add to dashboard Cite

Cryolipolysis is a noninvasive technique of localized fat reduction. Controlled cold exposure is performed in the selective destruction of fat cells. The aim of this study was to investigate the effects of cryolipolysis on adipocytes elimination through histological and sonographic analyses. This study reports the case of a 46-year-old female patient, with complaint of localized abdominal fat and in the preoperative period of abdominoplasty. The patient was submitted to a single 60-minute application of cryolipolysis, temperature of −5°C, on the hypogastrium area, 5 cm below the umbilicus. To study the effects of this treatment, ultrasound images taken before the session and 7, 15, 30, and 45 days after the therapy were analysed. After the abdominoplasty, parts of the treated and the untreated withdrawn abdominal tissues were evaluated macro- and microscopically. In ultrasound images, as well as in macroscopic and histological analyses, significant adipocytes destruction was detected, with consequent fat layer reduction and integrity of areas that were adjacent to the treated tissue. The presence of fibrosis observed during therapy and acknowledged through performed analyses encourages further studies to clarify such finding.

show abstract

“…2, 7 Overall, reported side effects with ATX-101 in clinical trials were typically mild to moderate, transient, and localized to the injection site 4, 7, 10, 11. The most commonly reported events were minor and included pain, edema, erythema, and bruising; and notably, these events frequently occurred in the placebo groups as well 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13. This was not surprising because the aforementioned adverse events are the most common and expected effects associated with all injection-based procedures 3, 4, 11.…”

Section: Discussionmentioning

confidence: 97%