Alopecia after injection of ATX-101 for reduction of submental fat

Souyoul, Skylar; Gioe, Olivia; Emerson, Ashley; Hooper, Deirdre

doi:10.1016/j.jdcr.2017.02.021

Cited by 28 publications

(22 citation statements)

References 10 publications

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“…Adverse events caused by the use of deoxycholic acid can be divided into 2 groups: minor adverse events, which are very frequent and major ones, which are extremely rare. 15 , 17 – 20 With the exception of allergic reactions (which never occurred in this study), for both groups, the adverse events can be ascribed to localized problems during treatment. 21 – 25 Minor adverse events were oedema in the first 72 hours (78%), mild pain lasting more than 12 hours (60%), bruising (41%), warmth (39%), numbness (30%), erythema (28%), and nodules lasting less than 1 month (14 %).…”

Section: Resultsmentioning

confidence: 56%

Evaluation of Safe and Effectiveness of an Injectable Solution Acid Deoxycholic Based for Reduction of Localized Adiposities

Amore

Amuso

Leonardi

et al. 2018

Plastic and Reconstructive Surgery - Global Open

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Background:The use of deoxycholic acid to reduce localized fat deposits is a procedure that has been in use for about 30 years. Its effectiveness as treatment is due to emulsification of phospholipids and therefore, solubilization of the biological membranes with resulting fat necrosis. The purpose of the study was to assess the effectiveness and the safety of an injectable solution containing sodium deoxycholtate 1.25% (DB125), used as intralipotherapy.Methods:The effectiveness and safety of DB125 solution have been assessed with a multicentre observational prospective study carried out between February and October 2017. The 221 selected patients presented with various forms and degrees of localized fat in several areas. Intralipotherapy treatments were performed 6 weeks apart and until the clinical result was obtained. Aesthetic outcomes were evaluated by the authors using preoperative and postoperative photographic documentation and by the patients with their level of satisfaction by filling out an anonymous form. Major adverse events were reported by each doctor who performed the treatment.Results:Two hundred twenty-one patients treated in 273 cases of different localized fat deposits. One hundred eighty-five patients who could be assessed for final results gave the effectiveness of the treatment an average score of 7.4. The failure percentage of the treatment was 3.8%. The medical evaluation showed treatment success in 93.5% of cases. Adverse events can be divided into 2 groups: minor adverse events, which are very frequent and major ones, which are extremely rare. For both groups, the adverse events can be ascribed to localized problems in the treatment area.Conclusion:Studies have shown that the second-generation solution containing sodium deoxycholate 1.25% is effective and safe to treat different localized fat deposits. The high degree of effectiveness shown in the study was not associated with a lesser degree of handling because, at the doses indicated and with the use of intralipotherapy, the occurrence of adverse events was minimal.

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Section: Resultsmentioning

confidence: 56%

Evaluation of Safe and Effectiveness of an Injectable Solution Acid Deoxycholic Based for Reduction of Localized Adiposities

Amore

Amuso

Leonardi

et al. 2018

Plastic and Reconstructive Surgery - Global Open

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“…Injections were administered 1 cm 2 apart using a 30-gauge, half-inch needle at two-third–needle depth. 15 The only difference versus this procedure was the use of a 32-gauge needle in this study. The author of the case study proposed a need for postmarketing surveillance data to enable a more comprehensive description of AEs associated with DCA treatment.…”

Section: Discussionmentioning

confidence: 94%

“…As mentioned, in contrast to a single case report in the published literature, which mentions DCA-induced submental patchy alopecia that was persistent and refractory to treatment with topical bimatoprost after 11 months, the alopecia observed in this study was transient (6 weeks–12 months) and did not require treatment. 15 In the case report, a 37-year-old man underwent an STS comprising 21 discrete DCA injections (2 mg/injection) into the submental subcutaneous fat (SMFRS Grade 2). Injections were administered 1 cm 2 apart using a 30-gauge, half-inch needle at two-third–needle depth.…”

Section: Discussionmentioning

confidence: 99%

Real-World Experience With 100 Consecutive Patients Undergoing Neck Contouring With ATX-101 (Deoxycholic Acid): An Updated Report With A 2-Year Analysis

Shridharani

2019

Dermatol Surg

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BACKGROUNDDeoxycholic acid (DCA; ATX-101) injection was approved for the treatment of mild-to-moderate convexity associated with submental fat in 2015.OBJECTIVETo evaluate the experience with DCA injections in a clinical practice setting.MATERIALS AND METHODSThis ongoing, prospective, single-center, single-arm, observational study evaluated 100 consecutive patients treated with subcutaneous DCA (2 mg/cm2) injections (maximum 6 sessions at ≥1-month intervals). Treatment response was assessed using the clinician-reported submental fat rating scale (CR-SMFRS) and confirmed by independent physician review of photographs at 1 and 5 to 7 weeks after treatment.RESULTSSince the previous published report, 17 patients have undergone additional treatment sessions, with a total of 100 patients having undergone 195 treatment sessions: 41, 36, 14, 6, 2, and 1 patient underwent 1, 2, 3, 4, 5, and 6 sessions, respectively. Overall, 91.7% of patients in the single treatment session group and 100% in the multiple treatment session group had an improvement of ≥1 point on the CR-SMFRS. The mean (SD) duration of local edema, numbness, and tenderness after treatment was 7.1 (5.1), 27.9 (11.3), and 3.5 (3.5) days, respectively.CONCLUSIONDeoxycholic acid injections were generally well tolerated, and ≥2 treatment sessions were required to achieve the desired aesthetic goal in a private practice setting.

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“…A marginal mandibular nerve paresis was observed in two patients (Shridharani, ). Another very rare adverse effect is alopecia, but the mechanism behind is unknown (Souyoul, Gioe, Emerson, & Hooper, ).…”

Section: Injection Lipolysis With Atx‐101mentioning

confidence: 99%

“…(Shridharani, 2017). Another very rare adverse effect is alopecia, but the mechanism behind is unknown (Souyoul, Gioe, Emerson, & Hooper, 2017).…”

Section: Injection Lipolysis With Atx-101mentioning

confidence: 99%

Aesthetic dermatology: What's new, what's true?

Wollina

Brzeziński

2018

Dermatologic Therapy

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Aesthetic dermatology (AD) is a rapidly growing subspecialty of dermatology. The acceptance of AD in scientific community and the society is associated with its competence, efficiency, and seriousness. This review highlights some recent developments toward new tools, techniques, and understanding in the field of AD. Analyzing the specific needs of patients and assessing the effect by objective measurements is important for further progress. For long time ignored, white adipose tissue has gained increasing interest in biology and rejuvenation. Characterization of dermal and subcutaneous white adipose tissue has made progress. The interaction of hyaluronic acid and calcium hydroxyl apatite (CaHA) fillers with adipocytes could be responsible for clinical efficacy. New developments of oral collagen treatment and highly diluted CaHA to contour the body outside the face will be discussed. Submental contouring using purified desoxycholic acid is another new development.

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Alopecia after injection of ATX-101 for reduction of submental fat

Cited by 28 publications

References 10 publications

Evaluation of Safe and Effectiveness of an Injectable Solution Acid Deoxycholic Based for Reduction of Localized Adiposities

Evaluation of Safe and Effectiveness of an Injectable Solution Acid Deoxycholic Based for Reduction of Localized Adiposities

Real-World Experience With 100 Consecutive Patients Undergoing Neck Contouring With ATX-101 (Deoxycholic Acid): An Updated Report With A 2-Year Analysis

Aesthetic dermatology: What's new, what's true?

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