Safety and efficacy of common vitamin D supplementation in primary hyperparathyroidism and coexistent vitamin D deficiency and insufficiency: a systematic review and meta-analysis

Song, An; Zhao, Hongyan; Yang, Yuejin; Liu, Shuzhong; Nie, Min; Wang, O.; Xing, Xue-zhong

doi:10.1007/s40618-020-01473-5

Cited by 18 publications

(18 citation statements)

References 17 publications

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“…It has also been shown that increases in 25(OH)D up to 30 ng/mL are associated with a reduction in PTH levels. This observation was also made specifically in PHPT by the metanalysis by Song et al [ 81 ]. The safe use of vitamin D supplementation is also relevant.…”

Section: Different Disorders Require Different Circulating Levels Of 25(oh)d For Optimized Outcomessupporting

confidence: 56%

“…[ 80 ]. Primary Hyperparathyroidism: to control PTH level In a meta-analysis of 10 studies including 340 patients with PHPT, there was no significant worsening of hypercalcemia following vitamin D supplementation, with only 2.2% of patients developing serum calcium above 12 mg/dL [ 81 ]. In most studies, cholecalciferol and ergocalciferol were used, with significant heterogeneity across them.…”

Section: Different Disorders Require Different Circulating Levels Of 25(oh)d For Optimized Outcomesmentioning

confidence: 99%

“…Doses ranged from 800 IU daily to 50,000 IU twice weekly. Serum PTH decreased on average by 33% (p=0.003) [ 81 ]. Adequate levels of vitamin D in PHPT will help to control any tendency for PTH levels to rise further, if 25(OH)D levels fall below a threshold value.…”

Section: Different Disorders Require Different Circulating Levels Of 25(oh)d For Optimized Outcomesmentioning

confidence: 99%

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Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

Bilezikian

Formenti

Adler

et al. 2021

Rev Endocr Metab Disord

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The 4th International Conference on Controversies in Vitamin D was held as a virtual meeting in September, 2020, gathering together leading international scientific and medical experts in vitamin D. Since vitamin D has a crucial role in skeletal and extra-skeletal systems, the aim of the Conference was to discuss improved management of vitamin D dosing, therapeutic levels and form or route of administration in the general population and in different clinical conditions. A tailored approach, based on the specific mechanisms underlying vitamin D deficiency in different diseases that were discussed, was recommended. Specifically, in comparison to healthy populations, higher levels of vitamin D and greater amounts of vitamin D were deemed necessary in osteoporosis, diabetes mellitus, obesity (particularly after bariatric surgery), and in those treated with glucocorticoids. Emerging and still open issues were related to target vitamin D levels and the role of vitamin D supplementation in COVID-19 since low vitamin D may predispose to SARS-CoV-2 infection and to worse COVID-19 outcomes. Finally, whereas oral daily cholecalciferol appears to be the preferred choice for vitamin D supplementation in the general population, and in most clinical conditions, active vitamin D analogs may be indicated in patients with hypoparathyroidism and severe kidney and liver insufficiency. Parenteral vitamin D administration could be helpful in malabsorption syndromes or in states of vitamin D resistance.Specific guidelines for desired levels of vitamin D should be tailored to the different conditions affecting vitamin D metabolism with the goal to define disease-specific normative values.

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Section: Different Disorders Require Different Circulating Levels Of 25(oh)d For Optimized Outcomessupporting

confidence: 56%

Section: Different Disorders Require Different Circulating Levels Of 25(oh)d For Optimized Outcomesmentioning

confidence: 99%

Section: Different Disorders Require Different Circulating Levels Of 25(oh)d For Optimized Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

Bilezikian

Formenti

Adler

et al. 2021

Rev Endocr Metab Disord

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“…Hypovitaminosis D causes secondary hyperparathyroidism. In all patients with osteopenia and OP, frequent dosing of 25(OH)D blood levels is recommended in order to identify secondary hyperparathyroidism, which may require supplementation of 25(OH)D. This strategy allows one to decrease PTH blood values, facilitate optimal calcium absorption, and normalize the calcium bone metabolism [139][140][141].…”

Section: Endocrinological Diseases Vitamin D and Opmentioning

confidence: 99%

Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review

Martinis

Allegra

Sirufo

et al. 2021

IJMS

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Vitamin D (VD) is essential for bone homeostasis, but it is also involved in pleiotropic effects on various organs and tissues. In adults, VD deficiency can cause or exacerbate osteoporosis and induce osteomalacia. However, every tissue and cell in the body has a VD receptor, including the brain, heart, stomach, pancreas, skin, gonads, and immune cells, and a deficiency may modify the function of these organs. Thus, the wide-ranging actions of VD help to explain why a reduction in VD amount has been correlated with numerous chronic diseases. In fact, VD deficiency increases the risk of osteoporosis and several other diseases and complications characterized by impaired bone metabolisms, such as autoimmune diseases, inflammatory bowel diseases, allergy, endocrinological diseases, hematological malignancies, and bone marrow transplantation. This review aims to investigate the link between VD deficiency, osteoporosis, and its concomitant diseases. Further epidemiological and mechanistic studies are necessary in order to ascertain the real role of hypovitaminosis in causing the reported diseases; however, adequate vitamin supplementation and restoration of metabolic normality could be useful for better management of these pathologies.

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“…Vitamin D (VitD) is important for healthy living, and its pleiotropic effects go far beyond the mineral metabolism [1][2][3][4]. VitD measurement is especially recommended in patients with bone disorders and/or pathologies in calcium homeostasis.…”

Section: Introductionmentioning

confidence: 99%

A rapid point-of-care assay accurately measures vitamin D

Albrecht

Lotz

Frommer

et al. 2021

J Endocrinol Invest

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Purpose Vitamin D (VitD) is a pleiotropic hormone with effects on a multitude of systems and metabolic pathways. Consequently, the relevance of a sufficiently high VitD serum level becomes self-evident. Methods A rapid immunofluorescence assay designed for the point-of-care measurement of serum VitD3 solely was tested. Inter- and intra-assay validation, double testing and result comparison with a standardized laboratory method were performed. Results An overall linear correlation of r = 0.89 (Pearson, 95% CI 0.88–0.92, p < 0.01) between the point of care and the conventional reference assay was registered. Accuracy and precision were of special interest at cut-points (10 ng/ml [mean deviation 1.7 ng/ml, SD 1.98 ng/ml, SE 0.16 ng/ml], 12 ng/ml [MD 0.41, SD 1.89, SE 0.19] and 30 ng/ml [MD − 1.11, SD 3.89, SE 0.35]). Only a slight deviation was detected between the two assays when using fresh (r = 0.91, 95% CI 0.86–0.94, p < 0.01) and frozen serum samples (r = 0.86, 0.82–0.89, p < 0.01). Results remained steady when samples were frozen several times. Inter- and intra-assay validation according to the CLSI protocol as well as multiuser testing showed stable results. Conclusion This novel, innovative, and controlled study indicates that the evaluated rapid point of care VitD assay is reliable, accurate, and suited for clinical practice.

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Safety and efficacy of common vitamin D supplementation in primary hyperparathyroidism and coexistent vitamin D deficiency and insufficiency: a systematic review and meta-analysis

Cited by 18 publications

References 17 publications

Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review

A rapid point-of-care assay accurately measures vitamin D

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