Safety and efficacy of a self-developed Chinese pelvic repair system and Avaulta repair system for the treatment of pelvic organ prolapse in women

Ouyang, Yiqin; Chen, Rujun; Chu, Lei; Liang, Junhua; Zhang, Xueyu; Li, Li; Gao, Tian; Li, Huaifang; Tong, Xiaowen

doi:10.1097/md.0000000000022332

Cited by 2 publications

(2 citation statements)

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“…Obviously, hydrogel was not crosslinked in lower concentration. The PPM was woven with polypropylene monofilaments according to our previous studies [ 41 ]. GelMA and TA@GelMA hydrogels were successfully crosslinked on the PPM and fabricated coatings ( Fig.…”

Section: Resultsmentioning

confidence: 99%

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Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and anti-inflammatory capacity for facilitating pelvic floor repair

Zhou²,

You

et al. 2022

Regenerative Biomaterials

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The application of polypropylene mesh (PPM) in pelvic organ prolapse (POP) treatment was severely limited by the complications associated with PPM, such as mesh exposure, chronic inflammatory reactions, and postoperative hematoma. This study applied a method of fabricating a hydrogel-mesh complex (PPM+TA@GelMA) to cross-link tannic acid (TA) directly with Methacrylate Gelatin (GelMA) hydrogel and thus to form a coating for polypropylene mesh. This one-step coating modification improved the hydrophilicity and cyto-compatibility of PPM. The hemostatic effect of PPM+TA@GelMA was confirmed through tail amputation test. Through the defect tissue repair experiments in vivo, it was proved that PPM+TA@GelMA had effects of anti-inflammation and promoting tissue repair, and regulated the M2 subtype macrophages polarization for tissue repair. The TA-loaded hydrogel coating endued PPM with multiple functions. It is believed that the novel hydrogel-mesh complex and its fabrication method will have great significance in basic research and clinical application.

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Section: Resultsmentioning

confidence: 99%

“…TA, gelatin, MA, lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) and trypsin were from Sigma-Aldrich (St Louis, US). PPMs were self-woven according to the previous study [ 41 ]. BARD meshes were purchased from BARD Corporation (USA).…”

Section: Methodsmentioning

confidence: 99%