Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and anti-inflammatory capacity for facilitating pelvic floor repair

Abstract

The application of polypropylene mesh (PPM) in pelvic organ prolapse (POP) treatment was severely limited by the complications associated with PPM, such as mesh exposure, chronic inflammatory reactions, and postoperative hematoma. This study applied a method of fabricating a hydrogel-mesh complex (PPM+TA@GelMA) to cross-link tannic acid (TA) directly with Methacrylate Gelatin (GelMA) hydrogel and thus to form a coating for polypropylene mesh. This one-step coating modification improved the hydrophilicity and cyto-compatibility of PPM. The hemostatic effect of PPM+TA@GelMA was confirmed through tail amputation test. Through the defect tissue repair experiments in vivo, it was proved that PPM+TA@GelMA had effects of anti-inflammation and promoting tissue repair, and regulated the M2 subtype macrophages polarization for tissue repair. The TA-loaded hydrogel coating endued PPM with multiple functions. It is believed that the novel hydrogel-mesh complex and its fabrication method will have great significance in basic research and clinical application.

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

“…The modified PPM displayed improved hydrophilicity and cytocompatibility. The complex exhibited hemostatic effects and, in vivo experiments, revealed anti-inflammatory characteristics, tissue repair promotion, and regulation of polarization of M2 subtype macrophage [198].…”

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

“…Hydrogels are a suitable platform for producing bleeding-controlling materials due to their exceptional liquid absorbing properties, which enable them to eliminate the excess of blood from the wound. Moreover, some hydrogels may be supplemented with substances promoting blood clot formation, including tannic acid [61][62][63], zeolite and kaolin [64][65][66], or polydopamine [67,68]. Such materials can actively and rapidly stop bleeding in wounds, promote clot formation, and minimize blood loss.…”

“…Such materials can actively and rapidly stop bleeding in wounds, promote clot formation, and minimize blood loss. This facilitates wound healing processes and reduces the risk of complications associated with uncontrolled bleeding [62,[69][70][71].…”

Mussel-inspired adhesive hydrogels for local immunomodulation

“…11b-i). 168 Subsequently, PPM + TA@GelMA was implanted in the rat abdominal wall muscle defect model. Owing to the synergistic effect of TA and GelMA, PPM + TA@GelMA had a hemostatic effect, which was beneficial for postoperative hemostasis or to reduce possible hematoma formation.…”