Safety and Effectiveness of Cryosurgery on Advanced Pancreatic Cancer

Tao, Zhen; Tang, Yong; Li, Baoguo; Yuan, Zhanna; Liu, Feng Hua

doi:10.1097/mpa.0b013e318243a503

Cited by 7 publications

(8 citation statements)

References 5 publications

(1 reference statement)

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“…Nonetheless, we believe that this case is worthy of attention, since PCA, as well as other ablative procedures, has been gaining popularity as a minimally invasive palliative procedure in patients with unresectable locally advanced pancreatic cancer, and several authors reported its effectiveness and safety in selected patients. 2 , 3 , 5 , 12 To the best of our knowledge, however, ours is the first description of the use of PCA in the setting of an isolated local recurrence of pancreatic cancer. Besides, the patient underwent PCA with no complications and was discharged on postoperative day 2.…”

Section: Discussionmentioning

confidence: 89%

“…However, recent advances in image-guided percutaneous techniques and instruments have led to a surge in the application of PCA in patients with pancreatic cancer. 2 , 3 In fact, some studies and literature reviews have shown the safety and feasibility of PCA for unresectable or not amenable to surgery pancreatic cancer, although its use remains restricted to very selected cases in expert hands. The risk of vascular injuries from cold temperatures is hampered by the fact that the rapid blood flow in the large vessels close to the pancreas has a hot pool effect.…”

Section: Discussionmentioning

confidence: 99%

“…The risk of vascular injuries from cold temperatures is hampered by the fact that the rapid blood flow in the large vessels close to the pancreas has a hot pool effect. 3 , 4 …”

Section: Discussionmentioning

confidence: 99%

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Computed Tomography-Guided Cryoablation of Local Recurrence after Primary Resection of Pancreatic Adenocarcinoma

Pusceddu

Melis

Sotgia

et al. 2015

Clinics and Practice

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The optimal management of local recurrences after primary resection of pancreatic cancer still remains to be clarified. A 58-year-old woman developed an isolated recurrence of pancreatic cancer six year after distal pancreatectomy. Re-resection was attempted but the lesion was deemed unresectable at surgery. Then chemotherapy was administrated without obtaining a reduction of the tumor size nor an improvement of the patient’s symptoms. Thus the patient underwent percutaneous cryoablation under computed tomography (CT)-guidance obtaining tumor necrosis and a significant improvement in the quality of life. A CT scan one month later showed a stable lesion with no contrast enhancement. While the use of percutaneous cryoblation has widened its applications in patients with unresectable pancreatic cancer, it has never been described for the treatment of local pancreatic cancer recurrence after primary resection. Percutaneous cryoablation deserves further studies in the multimodality treatment of local recurrence after primary pancreatic surgery.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Computed Tomography-Guided Cryoablation of Local Recurrence after Primary Resection of Pancreatic Adenocarcinoma

Pusceddu

Melis

Sotgia

et al. 2015

Clinics and Practice

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“…For 20 years, this method was used as a treatment of pancreatic carcinomas in men [17]. In a review in 2012, Zhen Tao studied the safety and efficacy of cryosurgery in local advanced pancreatic tumors [18]. In his article, he analyzed five studies that included the necessary criteria to evaluate the method (Table 3).…”

Section: Radiofrequency Ablationmentioning

confidence: 99%

Treatment of Insulinomas with Minimally Invasive Physical Procedure. Literature Review

Берелавичус

Кригер

Dugarova

et al. 2018

SN Compr. Clin. Med.

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Insulinoma is the most common functioning pancreatic neuroendocrine tumor with the development of the organic hyperinsulinism and the severe hypoglycemia. Insulinoma can be treated radically only by surgical removal. In cases when the surgery may cause severe complications with the high risk of mortality, the physical non-surgical methods can be used. The world literature review using PubMed, MedScape, and Cochrane databases was performed. Keywords Binsulinoma^+ Bphysical methods^were used including every type of the method. One hundred fifty-two articles in English devoted to different physical methods of treatment of neuroendocrine tumors were found. Twenty-seven papers with the description of the minimally invasive treatment of insulinomas were found among them. There were data about the different methods revealed such as radiofrequency ablation, microwave ablation, cryodestruction, laser ablation, irreversible electroporation, photodynamic therapy, high-intensity focused ultrasound, Cyberknife, and tumor alcoholization. Literature search showed that there are a few papers about the description of the self-experience of each method, but there are no papers with the full compartment of advantages and disadvantages of each method of treatment. Each method was used because of its availability in the hospital or department. Contemporary statement of the physical mini-invasive method of insulinomas treatment requires investigations with the full randomized trials. These researches can identify the points to use one or another physical method and to choose the most right way to treat patients with hormonal-producing pancreatic neuroendocrine tumors.

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“…Cryoablation has also been reported in the literature for pancreatic cancer [ 32 , 33 ]. Although RF has been more commonly used, and irreversible electroporation has recently become popular in pancreatic cancer, both techniques have been associated with significant risk of complications [ 34 , 35 ].…”

Section: Cryoablation In Other Locationsmentioning

confidence: 99%

Use of cryoablation beyond the prostate

Yılmaz

Özdoğan²,

Cevener

et al. 2016

Insights Imaging

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Cryoablation has been used for many years as a surgical ablation technique in the prostate and kidney. However, since the introduction of high-intensity focused ultrasound (HIFU) and robotic surgery for prostate tumours, its popularity in the urologic community has declined. In the early 2000s, innovations in cryoablation technology allowed the use of thinner probes, which were suitable for percutaneous application. As a result, radiologists began using cryoablation, first in the liver, and then in other organs or tissues such as the kidney, lung, breast, pancreas, bone, and soft tissue. In most of these locations, cryoablation has great potential given its inherent advantages, including the use of local anaesthesia, little or no pain during and after the procedure, real-time monitoring of the ablation area on US, CT or MRI, the potential for ablation of large tumours with multiple probes, and the ability to change the shape of the ablation in non-spherical tumours. Yet despite these advantages, the use of percutaneous cryoablation among radiologists appears to be far lower than that of heat-based ablation techniques. The aim of this article is to outline specific aspects of cryoablation and to illustrate its potential clinical applications with case presentations.Key Points• Recent advances have made cryoablation suitable for percutaneous use by radiologists with image guidance.• Cryoablation has distinct advantages over heat-based ablation techniques.• Cryoablation is becoming increasingly popular for lung, breast, kidney, bone, and soft tissue tumours.

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Safety and Effectiveness of Cryosurgery on Advanced Pancreatic Cancer

Cited by 7 publications

References 5 publications

Computed Tomography-Guided Cryoablation of Local Recurrence after Primary Resection of Pancreatic Adenocarcinoma

Computed Tomography-Guided Cryoablation of Local Recurrence after Primary Resection of Pancreatic Adenocarcinoma

Treatment of Insulinomas with Minimally Invasive Physical Procedure. Literature Review

Use of cryoablation beyond the prostate

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