Safety and Clinical Efficacy of Laparoscopic Appendectomy for Pregnant Women with Acute Appendicitis

Eom, Jung Seop; Jeon, Sohee; Choi, Joong Sub; Lee, Jung Hun; Kim, Hyung Ook; Kim, Hungdai; Choi, Pil Cho; Han, Sang Kuk

doi:10.47102/annals-acadmedsg.v41n2p82

Cited by 29 publications

(20 citation statements)

References 14 publications

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“…Fourteen studies reported population-based data, [10][11][12]15,22,23,26,29,31,33,35,42,45,50 three studies reported multicenter data 36,39,60 and 43 studies reported single-center data, 13,14,[16][17][18][19][20][21]24,25,27,28,30,32,34,37,38,40,41,43,44,[46][47][48][49][51][52][53][54][55][56][57][58][59][61]…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen studies reported population-based data, 10–12,15,22,23,26,29,31,33,35,42,45,50 three studies reported multicenter data 36,39,60 and 43 studies reported single-center data, 13,14,16–21,24,25,27,28,30,32,34,37,38,40,41,43,44,46–49,51–59,61–69 and all, expect one small prospective single-center study on 22 women,63 were retrospective.…”

Section: Resultsmentioning

confidence: 99%

“…42,46,62,68 There were no data on the type of morbidity in four studies. 24,26,31,33 Surgical site infection/fever (n = 43) was reported in 17 studies, 17,18,27,28,30,32,[37][38][39]41,48,49,52,54,60,64,69 and postoperative hemorrhage/hemoperitoneum was reported in two studies. 54,58 There was no maternal morbidity related to non-obstetric surgery in four studies.…”

Section: Description Of the Studies According To The Fetal And Matern...mentioning

confidence: 99%

“…Appendectomy is one of the most common surgeries during pregnancy, and 31 studies evaluated pregnancy outcomes in women who underwent this procedure. 10, 13, 17, 18 22, 26, 28, 31,32,36-39, 41, 45, 46,48-55, 57, 62–66, 68, 69…”

Section: Description Of the Studies According To The Type Of Surgerymentioning

confidence: 99%

“…Data for miscarriage (fetal loss before 20 weeks of pregnancy) were reported in 25 studies. 13,16–18,21,23–25,29,34–37,40,41,46,48,51–53,55,57,58,65,67 In the majority of these studies gestational age at surgery was reported, and the timing of the intervention being in the early pregnancy was verified. The prevalence of miscarriage was 3.9% in pregnancies where the mother had non-obstetric surgery ( n = 54,223).…”

Section: Description Of the Studies According To The Fetal And Matern...mentioning

confidence: 99%

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Non-obstetric surgery during pregnancy and the effects on maternal and fetal outcomes: A systematic review

et al. 2023

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Background and objective: Non-obstetric surgery is fairly common in pregnant women. We performed a systematic review to update data on non-obstetric surgery in pregnant women. The aim of this review was to evaluate the effects of non-obstetric surgery during pregnancy on pregnancy, fetal and maternal outcomes. Methods: A systematic literature search of MEDLINE and Scopus was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search span was from January 2000 to November 2022. Thirty-six studies matched the inclusion criteria, and 24 publications were identified through reference mining; 60 studies were included in this review. Outcome measures were miscarriage, stillbirth, preterm birth, low birth weight, low Apgar score, and infant and maternal morbidity and mortality rates. Results: We obtained data for 80,205 women who underwent non-obstetric surgery and data for 16,655,486 women who did not undergo surgery during pregnancy. Prevalence of non-obstetric surgery was between 0.23% and 0.74% (median 0.37%). Appendectomy was the most common procedure with median prevalence of 0.10%. Near half (43%) of the procedures were performed during the second trimester, 32% during the first trimester, and 25% during the third trimester. Half of surgeries were scheduled, and half were emergent. Laparoscopic and open techniques were used equally for abdominal cavity. Women who underwent non-obstetric surgery during pregnancy had increased rate of stillbirth (odds ratio (OR) 2.0) and preterm birth (OR 2.1) compared to women without surgery. Surgery during pregnancy did not increase rate of miscarriage (OR 1.1), low 5 min Apgar scores (OR 1.1), the fetus being small for gestational age (OR 1.1) or congenital anomalies (OR 1.0). Conclusions: The prevalence of non-obstetric surgery has decreased during last decades, but still two out of 1000 pregnant women have scheduled surgery during pregnancy. Surgery during pregnancy increases the risk of stillbirth, and preterm birth. For abdominal cavity surgery, both laparoscopic and open approaches are feasible.

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