Safety and Accuracy of Percutaneous Core Needle Biopsy in Examining Pancreatic Neoplasms

Ultrasound-guided percutaneous fine-needle aspiration of solid pancreatic neoplasms: 10-year experience with more than 2,000 cases and a review of the literature

“…Several authors have evaluated the sensitivity and accuracy of pancreatic biopsy. The largest published series [33][34][35][36][37][38] reported sensitivity and accuracy of 86 -99.2 % and 86 -93 %, respectively, therefore comparable to those of FNA. It must be otherwise noted that the complication rate of biopsy reported in these studies was higher than that of FNA (3.3-21 %).…”

Comparison of Ultrasound‐Guided Core Needle Biopsy and Endoscopic Ultrasound‐Guided Fine‐Needle Aspiration for Solid Pancreatic Lesions

“…The sensitivity of US‐guided CNB has been reported to be 71% to 99% 13 – 15 . Previously estimated sensitivity and specificity of EUS‐guided FNA (75%–92% and 82%–100%, respectively) are comparable to the values in our study.…”

“…Previously estimated sensitivity and specificity of EUS‐guided FNA (75%–92% and 82%–100%, respectively) are comparable to the values in our study. Sensitivity values of EUS‐guided FNA and US‐guided CNB are reportedly lower in patients with chronic pancreatitis than in those without chronic pancreatitis 10 , 15 . Our study enrolled 10 patients with pancreatitis, which might have affected the sensitivity of both modalities.…”

Towards a clinical use of miRNAs in pancreatic cancer biopsies

“…A recent meta-analysis has shown that pooled sensitivity for malignant cytology was 85% and specificity was 98%, and if suspicious cytological results were included to determine true neoplasms, the sensitivity increased to 91%, but specificity dropped to 94% [7], whereas percutaneous CT-guided FNA of pancreatic lesions is normally used to simply confirm the diagnosis of malignancy before commencing palliative treatment [8]. The aim of the current study [1] was to "establish the feasibility of miRNA expression profiling of localised PDAC using material obtained from diagnostic FNA."…”