Safe‐by‐Design Exfoliation of Niobium Diselenide Atomic Crystals as a Theory‐Oriented 2D Nanoagent from Anti‐Inflammation to Antitumor

Miao, Zhaohua; Huang, Doudou; Wang, Yichuan; Li, Wei‐Jian; Fan, Linxin; Wang, Jingguo; Ma, Yan; Zhao, Qingliang; Zha, Zhengbao

doi:10.1002/adfm.202001593

Cited by 28 publications

(24 citation statements)

References 38 publications

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“…Indeed, niobium diselenide was demonstrated to effectively eliminate reactive oxygen and nitrogen species via hydrogen atom transfer and redox reaction, following inhibition of inflammation, likely reducing the efficacy of cancer treatment. [73]…”

Section: Transition Metal Dichalcogenidesmentioning

confidence: 99%

Recent Advances in 2D Material‐Mediated Immuno‐Combined Cancer Therapy

Bianco

2021

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metal carbides or nitrides. [3][4][5][6][7][8] Based on their different properties, such 2D materials could be used as efficient means for drug delivery, photothermal therapy (PTT, which utilizes photothermal agents to convert light energy into hyperthermia, leading to the thermal ablation of cancer cells), photodynamic therapy (PDT, which uses photosensitizers to transfer photon energy into reactive oxygen species, provoking cancer cell death), chemodynamic therapy (CDT, which is based on Fenton or Fenton-like reactions to convert H 2 O 2 into hydroxyl radicals triggering apoptosis and inhibiting tumor growth), radiotherapy (RT, which uses high-dose radiation to kill cancer cells and eliminate tumors), radiodynamic therapy (RDT, which utilizes ionizing radiation to excite photosensitizers to generate 1 O 2 against cancer), and specific combination thereof. [8][9][10] In the years, cancer immunotherapy gets exceptional growing progress, especially after ipilimumab obtained the approval from FDA. [11] Ipilimumab is a monoclonal antibody directed towards cytotoxic T-lymphocyte-associated protein 4 (CTLA4) showing a significant increase in the survival of patients with metastatic melanoma. It is well known that cancer immunotherapy is based on immune system activation to target and eradicate cancer cells with durable antitumor responses and less metastasis and recurrence than other therapeutic strategies. [12,13] Immune biochemical factors, vaccines, checkpoint inhibitors, monoclonal antibodies, and other molecules have been widely utilized as efficient modulators to activate the immune system. Checkpoint blockade immunotherapy is a recently developed strategy based on the use of checkpoint inhibitors to arrest the immunosuppressive pathways promoting antitumor T cell activation and maintaining the antitumor T cell effector function. [14,15] However, the cancer immunotherapy efficiency is still not satisfactory. Indeed, the overall patient response rates are usually below 40% by checkpoint inhibitor therapy. [16] Meanwhile, immunotherapy can trigger mild to serious side effects, such as nausea, vomiting, lung/skin/gastrointestinal/renal toxicities, hypothyroidism, arthralgia, vasculitis, autoimmune hepatitis, and other dysfunctions. [17,18] To reduce or to overcome the side effects caused by immunotherapy, and further enhance its efficiency, 2D materials provide incomparable advantages, including high specific surface area, biocompatibility, chemical surface modification, targeting possibility, tumor accumulation, and unique physicochemical In the last years, cancer immunotherapy has started to attract a lot of attention, becoming one of the alternatives in the clinical treatment of cancer. Indeed, one of the advantages of immunotherapy is that both primary and distant tumors can be efficiently eradicated through a triggered immune response. Due to their large specific surface area and unique physicochemical properties, 2D materials have become popular in cancer immunotherapy, especially as efficient drug carriers. ...

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Section: Transition Metal Dichalcogenidesmentioning

confidence: 99%

Recent Advances in 2D Material‐Mediated Immuno‐Combined Cancer Therapy

Bianco

2021

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“…In addition, previous reports have confirmed that single‐layer 2D materials possess the advantages of high specific surface area, stability, better thermal conductivity, and high light transmittance. [ 12 , 13 , 14 ] Moreover, 2D nanomaterials show great potential and prospects in nano‐medicine, energy storage, electromagnetic materials, and optical materials. [ 15 , 16 , 17 ] Silicon is widely distributed in many organs (such as bones, hair, and skin).…”

Section: Introductionmentioning

confidence: 99%

Intravital Whole‐Process Monitoring Thermo‐Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long‐Term Microscopic Precise Imaging Strategy

et al. 2021

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Tumor angiogenesis is a complex process that is unamenable to intravital whole‐process monitoring, especially on microscopic assessment of tumor microvessel and quantifying microvascular hemodynamics before and after the nanotherapeutics, which hinder the understanding of nanotheranostics outcomes in tumor treatment. Herein, a new photoacoustic (PA) imaging‐optical coherence tomography angiography (OCTA)‐laser speckle (LS) multimodal imaging strategy is first proposed, which is not only able to precisely macro guide the thermo‐chemotherapy of tumor by monitoring blood oxygen saturation (SaO2) and hemoglobin content (HbT), but also capable of long‐term microscopic investigating the microvessel morphology (microvascular density) and hemodynamics changes (relative blood flow) before and after the nanotherapeutics in vivo. Moreover, to realize the tumor thermo‐chemotherapy treatment based on this novel multimodal imaging strategy, a 2D 5‐fluorouracil silicon nanosheets (5‐Fu‐Si NSs) therapeutic agent is designed. Furthermore, 2D high‐resolution tumor microvascular images in different stage display that tendency of the thermo‐chemotherapy effect is closely associated with tumor angiogenesis. Taken together, the investigations establish the fundamental base in theory and technology for further tailoring the novel specific diagnosis and treatment strategy in tumor. More importantly, this technique will be beneficial to evaluate the tumor microvascular response to nanotherapeutics at microscale.

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“…This article preliminarily summarized the latest research progress of tumor immune checkpoint combined therapy on account of the nano-drug delivery system to enhance tumor efficacy, and discussed its prospects and clinical transformation prospects. [5]…”

Section: Introductionmentioning

confidence: 99%

“…They use the nano‐drug delivery system to co‐deliver a variety of immunomodulators, combined with chemotherapy or photodynamic therapy and therefore significantly improve the effect of tumor treatment. This article preliminarily summarized the latest research progress of tumor immune checkpoint combined therapy on account of the nano‐drug delivery system to enhance tumor efficacy, and discussed its prospects and clinical transformation prospects [5] …”

Section: Introductionmentioning

confidence: 99%

Combined Application of Nanotechnology and Multiple Therapies with Tumor Immune Checkpoints

Sun

et al. 2020

ChemistrySelect

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Tumor immunotherapy has received worldwide attention in cancer treatment owing to its apparent advantages, such as strong specificity and long curative effect. Among them, significant progress has been made on the immune checkpoint therapy in recent years. FDA approved PD‐L1/PD‐1 and CTLA‐4 immune checkpoint inhibitors have been broadly used in a variety of malignant tumors. However, because of the low response rate of immune checkpoint drugs, its clinical application has been greatly hindered. With the prominence of nanotechnology in bio‐medicine, the application of nanotechnology in immune checkpoints has also gained more and more attention. The combination of radiotherapy, chemotherapy, phototherapy, magnetic therapy and other methods in nanotechnology makes an excellent promoting effect in the treatment of immune checkpoint drugs. This article reviews the recent breakthroughs of nanotechnology in immune checkpoint blocking therapy, mainly focusing on the significant advantages of the combination of nanotechnology‐based immune checkpoint blocking therapy with other treatment methods. In addition, we also discussed the challenges in this area and pointed out some potential directions for future development.

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Safe‐by‐Design Exfoliation of Niobium Diselenide Atomic Crystals as a Theory‐Oriented 2D Nanoagent from Anti‐Inflammation to Antitumor

Cited by 28 publications

References 38 publications

Recent Advances in 2D Material‐Mediated Immuno‐Combined Cancer Therapy

Recent Advances in 2D Material‐Mediated Immuno‐Combined Cancer Therapy

Intravital Whole‐Process Monitoring Thermo‐Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long‐Term Microscopic Precise Imaging Strategy

Combined Application of Nanotechnology and Multiple Therapies with Tumor Immune Checkpoints

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