Safe and Effective Delivery of Amphotericin B: A Survey of Patents

Kaur, Lakhvir; Abhijeet,; Jain, Subheet Kumar

doi:10.2174/1872210511666170105130210

Cited by 7 publications

(7 citation statements)

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“…The findings of this study demonstrated that flake-loaded in situ gel is a potential novel vehicle for VVC treatment [143]. On the other hand, the clinical use of AmB is limited because of its toxic side effects and low aqueous solubility [144,145]. In this context, Kim et al formulated a thermosensitive in situ vaginal gel using Pluronic-based triblock copolymer derivative (MBCP-2) loaded with AmB which could selectively degrade under acidic vaginal conditions [146].…”

Section: Multi-stimuli Responsive Systemsmentioning

confidence: 90%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

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An optimal host–microbiota interaction in the human vagina governs the reproductive health status of a woman. The marked depletion in the beneficial Lactobacillus sp. increases the risk of infection with sexually transmitted pathogens, resulting in gynaecological issues. Vaginal infections that are becoming increasingly prevalent, especially among women of reproductive age, require an effective concentration of antimicrobial drugs at the infectious sites for complete disease eradication. Thus, topical treatment is recommended as it allows direct therapeutic action, reduced drug doses and side effects, and self-insertion. However, the alterations in the physiological conditions of the vagina affect the effectiveness of vaginal drug delivery considerably. Conventional vaginal dosage forms are often linked to low retention time in the vagina and discomfort which significantly reduces patient compliance. The lack of optimal prevention and treatment approaches have contributed to the unacceptably high rate of recurrence for vaginal diseases. To combat these limitations, several novel approaches including nano-systems, mucoadhesive polymeric systems, and stimuli-responsive systems have been developed in recent years. This review discusses and summarises the recent research progress of these novel approaches for vaginal drug delivery against various vaginal diseases. An overview of the concept and challenges of vaginal infections, anatomy and physiology of the vagina, and barriers to vaginal drug delivery are also addressed.

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Section: Multi-stimuli Responsive Systemsmentioning

confidence: 90%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

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“…For instance, 3-MeAsp needed to be decarboxylated to 3-aminoisobutyrate before being accepted by the ACP module and entering the phase of PKS I-type carbon chain extension. By investigating the compound structures and the BGCs gene cluster, we summarized and proposed that, except for 3-MeAsp, there are many other PMLs implicated in this metabolic route, such as sceliphrolactam (17), ciromicin A (74), sannastatin (34), bombyxamycin A (11), piceamycin (52), macrotermycin A-D (30-31,76,79), niizalactam C (58), verticilactam (59) and so on.…”

Section: Pmls Initial β-Amino Acid Unitsmentioning

confidence: 99%

“…PMLs exhibited a large spectrum of bioactivities such as antimicrobial (bombyxamycin A-C (11,12,42) [4], BE-14106 (22) [5] and ML449 (28) [6], antifungal (auroramycin (37) [7]), antitumor (vicenistatin (32) [8] and leinamycin (48) [9]) and anti-parasitic activities (lobosamides (13)(14)(15) [10] and sagamilactam (73) [11]), modulation of Bcl-xl function (incednine (35) [12]) and anti-inflammatory properties (cyclamenol A (1) [13]) (Table 1). Some typical PMLs compounds such as hitachimycin (49), BE-14106 (22), sceliphrolactam (17), heronamides (25- NO-corresponding to the serial number of the structure in Figures 1-3. Member-means how many atoms are in the single-closed ring structure.…”

Section: Introductionmentioning

confidence: 99%

Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities

et al. 2022

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Over the past few decades (covering 1972 to 2022), astounding progress has been made in the elucidation of structures, bioactivities and biosynthesis of polyene macrolactams (PMLs), but they have only been partially summarized. PMLs possess a wide range of biological activities, particularly distinctive fungal inhibitory abilities, which render them a promising drug candidate. Moreover, the unique biosynthetic pathways including β-amino acid initiation and pericyclic reactions were presented in PMLs, leading to more attention from inside and outside the natural products community. According to current summation, in this review, the chem- and bio-diversity of PMLs from marine and terrestrial sources are considerably rich. A systematic, critical and comprehensive overview is in great need. This review described the PMLs’ general structural features, production strategies, biosynthetic pathways and the mechanisms of bioactivities. The challenges and opportunities for the research of PMLs are also discussed.

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“…Using nanotechnology to wrap the administration method of AmB, improve the efficiency of the drug and greatly reduce the nephrotoxicity of AmB to the human body, such as lipid complex abelcet, dispersible colloidal particles and liposomal ambisome. However, there are problems such as price and stability (Kaur et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Enhancing the production of amphotericin B by Strepyomyces nodosus in a 50-ton bioreactor based on comparative genomic analysis

et al. 2021

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Amphotericin, as an important macrolide antibiotic, is synthesized by Streptomyces nodosus. A high-yield S. nodosus ZJB2016050 was obtained by mutagenesis in our lab with the advantages of high yield, short fermentation cycle and few by-products, which was more suitable for industrial production. The fermentation differences in 50-tons bioreactor between S. nodosus ATCC14899 and S. nodosus ZJB2016050 were compared. The amphotericin B (AmB) yield of S. nodosus ZJB2016050 was 9.73 mg/g at 96 h, which was 30% higher than that of S. nodosus ATCC14899. The by-product amphotericin A (AmA) production of S. nodosus ZJB2016050 was 78% lower than that of S. nodosus ATCC14899. By performing whole-genome sequencing of S. nodosus ZJB2016050 and comparative genome analysis with the wild-type S. nodosus ATCC14899, it was found that the two strains have high synteny, but each has a special gene fragment. The genes functions of fragment were identified in the amino acid transport and metabolism, carbohydrate metabolism and lipid transport and metabolism. The gene functions of SNP (single nucleotide polymorphism) genes were identified in amino acid transport and metabolism, carbohydrate metabolism, coenzyme metabolism and secondary metabolites biosynthesis. The difference in signal-regulation and transcription may be the main reason for the differences between these two strains. Three GntR family egulatory factors of S. nodosus ATCC14899 may reduce the synthesis of amphotericin. Based on the analysis of comparative genomes, the effects of corn oil in S. nodosus ATCC14899 and S. nodosus ZJB2016050 were also compared. The results showed that corn oil can promote the fermentation of S. nodosus ZJB2016050. The S. nodosus ZJB2016050 may degrade fatty acids faster, and the degraded acyl-coenzyme can be used to synthesize amphotericin.

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Safe and Effective Delivery of Amphotericin B: A Survey of Patents

Abstract: The purpose of the article is to present assimilated information regarding patents on Amphotericin B formulations and technologies.

Cited by 7 publications

References 0 publications

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities

Enhancing the production of amphotericin B by Strepyomyces nodosus in a 50-ton bioreactor based on comparative genomic analysis

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