Sacral Neuromodulation in the Management of Bladder Pain Syndrome/Interstitial Cystitis

Hernández-Hernández, David; Padilla‐Fernández, Bárbara; Navarro-Galmés, Miguel Ángel; Medler, Stephany Hess; Castro-Romera, María Milagros; Castro-Díaz, David Manuel

doi:10.1007/s11884-020-00579-z

Cited by 4 publications

(8 citation statements)

References 65 publications

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“…[91,92] The distal colon is controlled by a branch of the sacral nerve (the pelvic splanchnic nerve) rather than by the vagus. [93] Accordingly, the anti-inflammatory effect of SNS on the colon and bladder have been observed in the clinical studies for treating ulcerative colitis [94] and interstitial cystitis, [95] while the anti-inflammatory effect of SNS on other pelvic organs (e.g. ovaries and prostate) has not been clinically evaluated.…”

Section: Anti-inflammatory Effects Of Bemmentioning

confidence: 99%

Bioelectronic medicine for restoring autonomic balance in autoimmune diseases

Pikov¹

2023

Gut Microb Integr Wellness

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Section: Anti-inflammatory Effects Of Bemmentioning

confidence: 99%

Bioelectronic medicine for restoring autonomic balance in autoimmune diseases

Pikov¹

2023

Gut Microb Integr Wellness

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“…The electric pulses are supposed to modulate not only the spinal cord reflexes but also brain networks. 10 Despite no high-level evidence, SNS is recommended by major international guidelines as a fourth-line treatment in BPS/IC patients after failure of behavioural, oral and intravesical pharmacological treatments, including hydrodistension. Last update of American Urological Association (AUA) Guideline on BPS/IC management proposed an SNS trial before considering oral cyclosporine or major surgeries (cystoplasty or urinary diversion with or without cystectomy).…”

Section: Sacral Nerve Stimulationmentioning

confidence: 99%

“… 18 However, most studies have a mixed profile of patients and lack of homogeneous definitions of BPS/IC, making it difficult to contrast the results between them. 10 …”

Section: Sacral Nerve Stimulationmentioning

confidence: 99%

“… 10 Furthermore, subacute stimulation can be both performed with PNE and quadripolar tined lead, although it is usually specified in most papers. 10 …”

Section: Sacral Nerve Stimulationmentioning

confidence: 99%

“…10 Furthermore, subacute stimulation can be both performed with PNE and quadripolar tined lead, although it is usually specified in most papers. 10 Implications for research It has to be determined if phenotypical classification of IC/BPS is useful for predicting the success of SNS in these patients. A possible response can be the decrease in neuroinflammatory urine markers, such as nerve growth factor, P-substance or adenosine triphosphate (ATP).…”

Section: Sacral Nerve Stimulationmentioning

confidence: 99%

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Current role of neuromodulation in bladder pain syndrome/interstitial cystitis

Padilla‐Fernández

Hernández-Hernández

Castro-Díaz

2022

Therapeutic Advances in Urology

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Neuromodulation is recommended by major international guidelines as a fourth-line treatment in bladder pain syndrome/interstitial cystitis (BPS/IC) patients after failure of behavioural, oral and intravesical pharmacological treatments, including hydrodistension. A non-systematic review of studies identified by electronic search of MEDLINE was performed with no time limitation. A narrative synthesis of the existing evidence regarding the results of sacral, tibial and pudendal nerve stimulation in the management of BPS/IC was developed. Neuromodulation in pelvic chronic pain disorders, including BPS/IC, is a useful tool for refractory patients to conventional treatments. Sacral neuromodulation may be effective in patients with BPS without Hunner’s lesions, and the effect seems to be maintained in the mid- and long-term. Posterior tibial nerve stimulation can be offered to patients with BPS/IC in the context of a multidisciplinary approach. When pudendal neuralgia is suspected, selective pudendal nerve stimulation has a high response rate. The aetiology of the pain can influence the outcomes in the mid- and long-term of the different neuromodulation approaches, thus careful diagnosis is recommended.

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Animal models of interstitial cystitis/bladder pain syndrome

Tay,

Grundy

2023

Front. Physiol.

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Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic disorder characterized by pelvic and/or bladder pain, along with lower urinary tract symptoms that have a significant impact on an individual’s quality of life. The diverse range of symptoms and underlying causes in IC/BPS patients pose a significant challenge for effective disease management and the development of new and effective treatments. To facilitate the development of innovative therapies for IC/BPS, numerous preclinical animal models have been developed, each focusing on distinct pathophysiological components such as localized urothelial permeability or inflammation, psychological stress, autoimmunity, and central sensitization. However, since the precise etiopathophysiology of IC/BPS remains undefined, these animal models have primarily aimed to replicate the key clinical symptoms of bladder hypersensitivity and pain to enhance the translatability of potential therapeutics. Several animal models have now been characterized to mimic the major symptoms of IC/BPS, and significant progress has been made in refining these models to induce chronic symptomatology that more closely resembles the IC/BPS phenotype. Nevertheless, it's important to note that no single model can fully replicate all aspects of the human disease. When selecting an appropriate model for preclinical therapeutic evaluation, consideration must be given to the specific pathology believed to underlie the development of IC/BPS symptoms in a particular patient group, as well as the type and severity of the model, its duration, and the proposed intervention’s mechanism of action. Therefore, it is likely that different models will continue to be necessary for preclinical drug development, depending on the unique etiology of IC/BPS being investigated.

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Sacral Neuromodulation in the Management of Bladder Pain Syndrome/Interstitial Cystitis

Cited by 4 publications

References 65 publications

Bioelectronic medicine for restoring autonomic balance in autoimmune diseases

Bioelectronic medicine for restoring autonomic balance in autoimmune diseases

Current role of neuromodulation in bladder pain syndrome/interstitial cystitis

Animal models of interstitial cystitis/bladder pain syndrome

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