Sacral metastasis in a patient with endometrial cancer: Case report and review of the literature

Albareda, Judit; Herrera, Milagros García; Salvá, Antonio López; García-Donás, Jesús; Gonzalez, R.

doi:10.1016/j.ygyno.2008.04.005

Cited by 34 publications

(54 citation statements)

References 22 publications

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“…Previous cases have identified an endometrial cancer metastasis either in the cervical or thoracic vertebrae (Loizzi et al, 2006;Arnold et al, 2003); there is also a documented report reviewing an endometrial cancer patient who developed a sacral metastasis (Albareda et al, 2008). However, the current case report is extremely atypical insofar as the patient presented with an epidural metastasis in the lumbar sacral region; we are unaware of any comparable studies describing this condition.…”

Section: Discussionmentioning

confidence: 63%

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Spinal epidural metastasis in an endometrial carcinoma patient

Brown

Stallman

Wong

et al. 2012

Gynecologic Oncology Case Reports

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Section: Discussionmentioning

confidence: 63%

“…Furthermore, very rare cases of metastatic endometrial cancer infiltrating the cervical column and sacral region have been documented (Loizzi et al, 2006;Albareda et al, 2008), albeit none involving the spinal epidural space.…”

Section: Introductionmentioning

confidence: 99%

Spinal epidural metastasis in an endometrial carcinoma patient

Brown

Stallman

Wong

et al. 2012

Gynecologic Oncology Case Reports

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“…After screening, 16 studies were found to be eligible for inclusion (1 prospective cohort study on radiosurgery (level II) [32]; 2 case series (level III) [28,33]; 4 retrospective case series (level IV) [2,10,34,35] and 9 case reports (level IV) [36][37][38][39][40][41][42][43][44]; Table 1). …”

Section: Resultsmentioning

confidence: 99%

“…Six studies report on their results of surgery ranging from posterior decompression with(out) cementation and instrumentation [2,28,35,43] to abdominal sacral resection [33] and en bloc sacrectomy [34,44].…”

Section: Treatmentmentioning

confidence: 99%

Management of metastatic sacral tumours

et al. 2012

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Purpose Metastatic involvement of the sacrum is rare and there is a paucity of studies which deal with the management of these tumours since most papers refer to primary sacral tumours. This study aims to review the available literature in the management of sacral metastatic tumours as reflected in the current literature. Methods A systematic review of the English language literature was undertaken for relevant articles published over the last 11 years (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010). The PubMed electronic database and reference lists of key articles were searched to identify relevant studies using the terms ''sacral metastases'' and ''metastatic sacral tumours''. Studies involving primary sacral tumours only were excluded. For the assessment of the level of evidence quality, the CEBM (Oxford Centre of Evidence Based Medicine) grading system was utilised. Results The initial search revealed 479 articles. After screening, 16 articles identified meeting our inclusion criteria [1 prospective cohort study on radiosurgery (level II); 2 case series (level III); 4 retrospective case series (level IV) and 9 case reports (level IV)]. Conclusion The mainstay of management for sacral metastatic tumours is palliation. Preoperative angioembolisation is shown to be of value in cases of highly vascularised tumours. Radiotherapy is used as the primary treatment in cases of inoperable tumours without spinal instability where pain relief and neurological improvement are attainable. Minimal invasive procedures such as sacroplasties were shown to offer immediate pain relief and improvement with ambulation, whereas more aggressive surgery, involving decompression and sacral reconstruction, is utilised mainly for the treatment of local advanced tumours which compromise the stability of the spine or threaten neurological status. Adjuvant cryosurgery and radiosurgery have demonstrated promising results (if no neurological compromise or instability) with local disease control.

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“…The tumor is confined to the uterus itself in 75% of the cases [3]. The incidence of bone metastasis from recurrent endometrial carcinoma is reported to be less than 15% [4]. In an autopsy study by Abdul-Karim et.al., the incidence of bone metastasis was found to be 25-27% [5], which is highest among the reported literatures and the vertebrae were the most common site, only 6/67 cases had known bone metastases while they were alive and all had high grade carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Isolated Clavicular Metastasis in a Patient with Endometrial Adenocarcinoma

Singh¹,

Kaur²,

Sharma³

et al. 2017

Gynecol Obstet

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Endometrial adenocarcinoma metastasizing to bones is rare, and isolated metastasis to clavicle is even more uncommon. We report a case of a 60-year-old woman diagnosed with endometrial adenocarcinoma found to have isolated metastasis to the clavicle during adjuvant radiotherapy. Following radiation therapy to the clavicle, patient was started on injection zoledronic acid. She was then planned for chemotherapy comprising of Paclitaxel and Carboplatin for six cycles. Due to lack of compliance, 5months after the initial diagnosis, she developed severe dyspnea due to disease progression and expired. We hereby discuss the treatment options as well as review the literature of prior published reports on endometrial adenocarcinoma with bone metastasis.

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Sacral metastasis in a patient with endometrial cancer: Case report and review of the literature

Cited by 34 publications

References 22 publications

Spinal epidural metastasis in an endometrial carcinoma patient

Spinal epidural metastasis in an endometrial carcinoma patient

Management of metastatic sacral tumours

Isolated Clavicular Metastasis in a Patient with Endometrial Adenocarcinoma

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